Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment

Evaluating Cardiovascular Risk in Chronic Kidney Disease Patients: A Biomarker Approach

“…Serum CysC is a new and promising marker for kidney dysfunction (Coll et al 2000;Marwyne et al 2011;Moran et al 2008). Numerous studies had found CysC to be a better marker of GFR than creatinine.…”

“…CysC is a 122-amino acid that belongs to a family of potent, noncovalent, competitive inhibitors of mammalian lysosomal cysteine proteinases. Unlike serum creatinine, CysC has a constant rate of production independent of age, sex or muscle mass and may be a better marker for renal function (Coll et al 2000;Marwyne et al 2011;Moran et al 2008). Several recent publications have also demonstrated that CysC was superior to serum creatinine for prediction of all-cause mortality, cardiovascular events and incident congestive heart failure in elderly communitybased cohorts (Joachim et al 2007).…”

Serum levels of cystatin C in elderly lung cancer patients

“…Serum Cys-C levels have been proposed to be an ideal marker of the GFR (3), and these levels are not dependent on muscle mass (20). Therefore, the serum level of Cys-C may be a better marker of GFR than serum Cre (2,3).…”

Short-Term Gestation, Long-Term Risk: Prematurity and Chronic Kidney Disease

“…Cystatin C, a nonglycosylated basic protein produced at a constant rate by all nucleated cells, 85 is more easily interpretable than creatinine because a single reference range can be used for any child over 1 year of age. 86 Cystatin C is a more sensitive marker of mild renal impairment than creatinine, 87,88 and mild elevations are seen in preterm infants at 12 to 36 months of age compared with term control subjects.…”