Evaluating Cardiovascular Risk in Chronic Kidney Disease Patients: A Biomarker Approach

Gafor, Abdul Halim Abdul; Mohd, Rozita; Cader, Rizna Abdul; Kong, Wei Yen; Mohamad, M.S.F.; Shah, Shamsul Azhar; Báin, Arbaiyah; Kong, Norella

doi:10.17576/jsm-2018-4701-18

Cited by 3 publications

(5 citation statements)

References 28 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, triglyceride levels in non-CVD patients were significantly higher than those of CVD patients with a p-value of (0.002). This result agreed with a previous research study performed in Malaysia in 2018 and showed that triglycerides were elevated in non-CVD patients [ 5 ]. This could be explained as individuals with CVD have more control over triglycerides levels than non-CVD patients as they are on medications.…”

Section: Discussionsupporting

confidence: 93%

“…In this patient population, dying from CVD is exponentially greater than the patient reaching end-stage renal disease [ 4 ]. It is a belief that CKD is a cardiovascular disease equivalent [ 5 ]. Additionally, there could be risk factors that are common between CKD and CVD, such as Diabetes and Hypertension [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…A study from Sri Lanka done in the year 2016-2017 reported that 39 out of the total 132 CKD patients had coronary artery events [3]. Adding to this, a Malaysian study showed that CKD patients developing CVD were older and that their systolic pressure was higher than non-CVD patients [5]. Unfortunately, no single biomarker has been used as a diagnostic biomarker for CVD in CKD patients in a clinical situation because CKD is a heterogeneous disease with several comorbidities.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prevalence and Risk Factors of Cardiovascular Disease in Chronic Kidney Disease Patients at King Abdulaziz University Hospital (KAUH)

Nabalawi,

Bamuflih,

Farid

et al. 2024

Cureus

View full text Add to dashboard Cite

Background: Chronic kidney disease (CKD) has emerged as a significant global health concern, with its incidence doubling over the past three decades. Cardiovascular diseases (CVD) pose a major threat to CKD patients, surpassing the risk of progressing to end-stage renal disease. While previous studies worldwide have shed light on this association, limited research has been conducted in Saudi Arabia regarding this burden. This study aims to fill this gap by identifying the prevalence and risk factors of CVD in CKD patients at King Abdulaziz University Hospital (KAUH), Jeddah, Saudi Arabia, between 2017 and 2022. Methods: A six-year retrospective review of medical records at KAUH was conducted, including 465 non-end-stage CKD patients aged 30 to 79. Data, including demographics, clinical information, and laboratory results, were collected and statistically analyzed to investigate the association between variables. Results: Out of 465 CKD patients, 262 (56.3%) were diagnosed with CVD, with congestive heart failure and ischemic heart disease being the most common types. The majority were male 259 (55.7%), non-Saudi 278 (59.8%), and aged 60 years and older 291 (62.6%). Hypertension 394 (84.7%) and diabetes mellitus 336 (72.3%) were prevalent comorbidities. Severely reduced left ventricular ejection fraction, proteinuria, diabetes mellitus, and higher BMI were identified as significant risk factors for CVD in CKD patients. Conclusion: This research contributes valuable insights into the prevalence and risk factors of CVD in CKD patients in Saudi Arabia, emphasizing the need for early detection and intervention. The identified risk factors provide a basis for developing targeted preventive strategies to mitigate this population's CVD burden.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence and Risk Factors of Cardiovascular Disease in Chronic Kidney Disease Patients at King Abdulaziz University Hospital (KAUH)

Nabalawi,

Bamuflih,

Farid

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…Health-related quality of life is a strong predictor of death and hospitalization, which may influence the prognosis and course of the illness. This decline in quality of life in dialysis patients is a result of death anxiety ( Abdul Gafor et al, 2018 ). Another factor contributing to the current sample’s low quality of life may be their old age, low socioeconomic level, and lack of education and unemployment ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

Quality of Life and Illness Acceptance among End-Stage Renal Disease (ESRD) Patients on Hemodialysis: The Moderating Effect of Death Anxiety during COVID-19 pandemic

Mushtaque¹,

Awais-E-Yazdan

Zahra³

et al. 2022

Omega (Westport)

View full text Add to dashboard Cite

The purpose of the study was to examine the quality of life and illness acceptance among ESRD patients with the moderating effects of death anxiety. The cross-sectional design was incorporated. The sample was comprised of 240 participants. Individuals with ESRD on hemodialysis were approached above 20 years of age. A self-administered questionnaire was used for data collection. The results revealed that COVID-19 has a significant impact on the quality of life of patients and their illness acceptance. Covid-19 affected the general health of patients, their psychological health, as well as their social relationships. The results also confirmed that death anxiety negatively moderates the relationship between quality of life and illness acceptance among ESRD patients. This study will shed light on the need to provide appropriate psychosocial care as well as supportive therapies to people with end-stage renal disease who are experiencing mental distress during and after the COVID-19 outbreak.

show abstract

Evaluation of Finger Photoplethysmography Fitness Index on Young Women with Cardiovascular Disease Risk Factors

Muhajir

Aminuddin²,

Ugusman³

et al. 2018

JSM

View full text Add to dashboard Cite

The use of photoplethysmography (PPG) as one of cardiovascular disease (CVD) marker has got more attention due to its simplicity, noninvasive and portable characteristics. Two new markers had been developed from PPG namely PPG fitness index (PPGF) and vascular risk prediction index (VPRI). The aim of the present study was to compare PPGF level between young women with and without CVD risk factors, to investigate the relationship between PPGF with other CVD markers and to assess the sensitivity of VRPI in classifying young women that have CVD risk factors. A total of 148 young women aged 20-40 years old with and without CVD risk factors were involved in this study. CVD risk factors comprised of abdominal obesity, hypertension, dyslipidemia, smoking and family history of premature CVD. Subjects were categorized into healthy or having CVD risk factor. Measurements taken were anthropometric data, blood pressure, lipid profile, pulse wave velocity (PWV), augmentation index (AIx), high sensitivity C-Reactive Protein (hs-CRP), PPGF and VRPI. SPSS version 20 was used for data analysis with p<0.05 as significant value. The mean subjects' age was 29.97±5.27 years old. There was no difference in PPGF level between groups (p>0.05). PPGF was independently determined by PWV (β=-0.31, p<0.001) and height (β=0.16, p=0.04). VRPI had 77.9% sensitivity in identifying subjects with CVD risk factor. In conclusion, PPGF correlates with PWV and has potential to be an indicator of aortic stiffness while VRPI is sensitive to classify those with CVD risk factor.

show abstract

Evaluating Cardiovascular Risk in Chronic Kidney Disease Patients: A Biomarker Approach

Abstract: Cardiovascular disease (CVD) is a major cause of morbidity and mortality in chronic kidney disease (CKD) patients. This study aimed to determine the roles of

Cited by 3 publications

References 28 publications

Prevalence and Risk Factors of Cardiovascular Disease in Chronic Kidney Disease Patients at King Abdulaziz University Hospital (KAUH)

Prevalence and Risk Factors of Cardiovascular Disease in Chronic Kidney Disease Patients at King Abdulaziz University Hospital (KAUH)

Quality of Life and Illness Acceptance among End-Stage Renal Disease (ESRD) Patients on Hemodialysis: The Moderating Effect of Death Anxiety during COVID-19 pandemic

Evaluation of Finger Photoplethysmography Fitness Index on Young Women with Cardiovascular Disease Risk Factors

Contact Info

Product

Resources

About