Serum cystatin C, a potent inhibitor of cysteine proteinases, is elevated in asthmatic patients

Overweight, Obesity, and Elevated Serum Cystatin C Levels in Adults in the United States

“…There are several lines of evidence that suggest serum cystatin C may have extra-renal sources, particularly in pathways that may associate with body weight. Serum cystatin C has been shown to be associated with thyroid function, corticosteroid administration, and C reactive protein, conditions that are associated with alterations in body weight [24][25][26] . Thus, there may be additional potential mechanisms for the association between BMI and serum cystatin C, observed in the current study, above and beyond kidney function.…”

Cystatin C: current position and future prospects

“…Although no rise in serum CysC concentrations was found in children suffering from nephrotic syndrome treated with high dose corticosteroids (57), contradictory results were found in other studies. An increase in CysC concentrations, dependent on corticosteroid doses was demonstrated in asthmatics (58) and in studies including adult renal transplant patients (59,60) and in children suffering from cancerous or renal disease (61). But it appears that the corticosteroid dose-dependent elevation of CysC concentration has little impact on the estimation of GFR in patients with low or moderately high glucocorticosteroid doses.…”

Are serum cystatin C levels influenced by steroid doses in lupus nephritis patients?

“…22 On the other hand, Cimerman et al observed an increase in CysC levels in patients with asthma, who had utilized metylprednisolone and oral glucocorticoid in comparison with those that had not used these drugs or received cyclosporine. 12 Similarly, it was shown in patients using metylprednisolone due to severe subarachnoidal hemorrhage that sCysC levels were higher after seven days of treatment than at the time of admission in the hospital. 37 Risch et al showed that kidney transplant recipients on low-dose prednisone therapy had greater sCysC levels compared with those on steroid-free immunosuppressive therapy, but it was reported that the groups were not perfectly matched.…”

“…7 Nevertheless, since its clinical application was initiated, conditions that could interfere on its serum concentration beyond renal function were reported, as corticosteroid therapy, thyroid dysfunction, chronic liver disease, malignancies, organ transplantation, and many others. 1,[8][9][10][11][12][13][14][15][16][17][18][19][20] In addition, some authors consider the possibility that sCysC values could be increased in the event of male gender, increasing age, weight, and height. Moreover, its levels could be influenced by smoking, similarly to C-reactive protein, as a marker of inflammation and cardiovascular mortality.…”

“…[21][22][23][24] In fact, the superiority of sCysC over sCreat in the evaluation of GFR was demonstrated in some circumstances, but it is still questionable whether nonrenal factors could interfere on its levels, as the use of glucocorticoids. [7][8][9][10][11][12][13] The aim of this study is to evaluate whether corticosteroids have an influence on sCysC levels. In order to test this hypothesis, we evaluated patients with lupus nephritis using different doses of PO and IV glucocorticoids.…”