Overweight, Obesity, and Elevated Serum Cystatin C Levels in Adults in the United States

Muntner, Paul; Winston, Jonathan; Uribarri, Jaime; Mann, David; Fox, Caroline S.

doi:10.1016/j.amjmed.2008.01.003

Cited by 127 publications

(101 citation statements)

References 23 publications

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“…Several studies indicate that increased body weight and obesity are associated with elevated serum cystatin C concentrations (13,14,15,17). The results presented here ( fig.…”

Section: Discussionsupporting

confidence: 71%

See 1 more Smart Citation

Serum Cystatin C in Relation to Fat Mass Loss After Bariatric Surgery"

Śledziński

Proczko-Markuszewska

Kaska

et al. 2012

Polish Journal of Surgery

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“…Several studies indicate that increased body weight and obesity are associated with elevated serum cystatin C concentrations (13,14,15,17). The results presented here ( fig.…”

Section: Discussionsupporting

confidence: 71%

“…Several recently reported studies indicate that increased body weight and obesity are associated with elevated serum cystatin C concentrations (13)(14)(15)(16)(17). For instance, a positive correlation betwen serum cystatin C concentrations and BMI has been reported (13,14,15).…”

mentioning

confidence: 93%

Serum Cystatin C in Relation to Fat Mass Loss After Bariatric Surgery"

Śledziński

Proczko-Markuszewska

Kaska

et al. 2012

Polish Journal of Surgery

View full text Add to dashboard Cite

“…Reference values for cystatin-C have shown to be between 0.52 and 0.98 mg/L with a standard deviation of 0.19 mg/L. 20 Elevated serum cystatin-C was defined as !1.09 mg/L at the study of Muntner et al 21 At least one SD elevation was assumed to be different among groups with regard to that paper. 21 Post-hoc power analysis revealed that this study has a power of 84% with these values.…”

Section: Discussionmentioning

confidence: 99%

“…20 Elevated serum cystatin-C was defined as !1.09 mg/L at the study of Muntner et al 21 At least one SD elevation was assumed to be different among groups with regard to that paper. 21 Post-hoc power analysis revealed that this study has a power of 84% with these values. Power analysis was performed using the G*Power software (G*Power Version 3.1.5, Kiel, Germany).…”

Section: Discussionmentioning

confidence: 99%

A comparison of the effects of ketamine and remifentanil on renal functions in coronary artery bypass graft surgery

et al. 2015

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We have investigated the effects of ketamine-based and remifentanil-based anesthetic protocol on perioperative serum cystatin-C levels, and creatinine and/or cystatin-C-based eGFR equations in terms of acute kidney injury in coronary artery bypass graft (CABG) surgery. Using a simple randomization method (coin tossing), patients were divided into the two groups and not-blinded to the anesthetist. Remifentanil-midazolam-propofol or ketamine-midazolam-propofol-based anesthetic regimen was chosen. Different eGFR formulas using creatinine (MDRD, CKD-EPI, Cockrauft Gault); cystatin-C (eGFR1, eGFR2) or a combination of creatinine and cystatin-C (eGFR 3) were used to calculate estimated glomerular filtration rates (eGFRs). Highsensitive troponin T was used to determine if ketamine use in coronary surgery contributed to myocardial cell damage. Thirty-seven patients were included in the study (remifentanil group ¼ 19, ketamine Group ¼ 18). Urea, creatinine, cystatin-C levels were comparable between the groups in all the measurement times and also postoperative day 2 samples showed statistically higher results compared to baseline (p50.001). Effects of ketamine and remifentanil on renal functions were found similar. Creatinine and cystatin-C-based eGFR equations resulted similar in our study. Reversible stage 1 acute kidney injury (AKI) was observed on postoperative day 2 in seven patients from the remifentanil group and six patients from the ketamine group. Hs-troponin T was found to be higher in postoperative day 1 samples; there were no significant difference between the groups. Our results indicated that patients who have normal renal functions undergoing on-pump coronary bypass surgery, effects of ketamine and remifentanil on renal functions in terms of AKI were found to be similar.

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“…Studies have shown that BMI is related to the serum levels of cystatin C (17)(18)(19). The mechanism of this association is unclear, but experimental evidence suggests that adipocyte tissues secrete large amounts of cystatin C, which can lead to the increased levels of serum cystatin C in obese individuals with high BMI (20).…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Estimated GFRs Based on Formulas of Serum Cystatin C and Serum Creatinine

Mousavinasab

Jalalzadeh

2017

Nephrourol Mon

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Background: Serum cystatin C has been identified as a marker for the estimation of glomerular filtration rate (GFR). Although this marker is more sensitive than creatinine, it is too expensive and not available in all laboratories. In this study, we compared cystatin C-based equations with creatinine-based formulas to select the most precise creatinine-based formula for estimating GFR in patients with chronic kidney disease (CKD).

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Overweight, Obesity, and Elevated Serum Cystatin C Levels in Adults in the United States

Abstract: Background-Although high body mass index (BMI) is a risk factor for hypertension, diabetes, and cardiovascular disease, limited data exist on the association of overweight and obesity with early stages of kidney disease.

Cited by 127 publications

References 23 publications

Serum Cystatin C in Relation to Fat Mass Loss After Bariatric Surgery"

Serum Cystatin C in Relation to Fat Mass Loss After Bariatric Surgery"

A comparison of the effects of ketamine and remifentanil on renal functions in coronary artery bypass graft surgery

A Comparison of Estimated GFRs Based on Formulas of Serum Cystatin C and Serum Creatinine

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