Serum Creatine Kinase Levels Following Three Different Isometric Exercise Regimens

Graves, James E.; Clarkson, Priscilla M.; Kirwan, John P.; Litchfield, Paul

doi:10.1249/00005768-198404000-00370

Cited by 6 publications

(2 citation statements)

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“…36%) but significant increase in serum CK activity was found following each of the three exercises. We have previously reported that forearm flexion isometric exercise results in a 143%-172% increase in CK activity (6,8). A difference in the exercise testing equipment may be responsible for this discrepancy.…”

Section: Discussionmentioning

confidence: 99%

“…Recent pilot data from our laboratory have demonstrated substantial soreness following exercises using maximal isometric contractions. We have also found that maximal isometric contractions result in significant increases in serum creatine kinase (CK) activity (5,6,8). Serum CK activity has been widely used as a marker of skeletal muscle injury (3,10,14,20).…”

Section: Introductionmentioning

confidence: 98%

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Muscle Soreness and Serum Creatine Kinase Activity Following Isometric, Eccentric, and Concentric Exercise

Clarkson¹,

Byrnes²,

McCormick³

et al. 1986

Int J Sports Med

197

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Serum creatine kinase (CK) activity and subjective ratings of muscle soreness were assessed in 28 college women following three different arm flexion exercise regimens. The subjects were randomly assigned to an eccentric, isometric, or concentric exercise regimen. Each regimen was equated for total work time and work-to-rest ratio. Blood samples for determination of serum CK activity and perceived soreness ratings were obtained prior to and 5, 10, and 25 h following each exercise. Significant increases in perceived soreness ratings were observed for each exercise regimen. The magnitude of the post-exercise increase in perceived soreness was greatest for the eccentric and the isometric exercises with minimal soreness following the concentric exercise. A small but significant increase in serum CK activity was observed following the three exercises (eccentric = 35.8%, concentric = 37.6%, isometric = 34.0%). The post-exercise serum CK increases did not differ significantly among the three regimens. The rise in serum CK activity suggests that muscle damage occurred during all three tasks. However, due to multiple factors which can affect serum CK levels, the increase in serum CK activity may not provide a sensitive indicator of the magnitude of the injury.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Muscle Soreness and Serum Creatine Kinase Activity Following Isometric, Eccentric, and Concentric Exercise

Clarkson¹,

Byrnes²,

McCormick³

et al. 1986

Int J Sports Med

197

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Serum creatine kinase activity following forearm flexion isometric exercise

Clarkson

Litchfield

Graves

et al. 1985

Europ. J. Appl. Physiol.

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The purpose of this study was to compare serum creatine kinase (CK) activity following two forearm flexion isometric exercise regimens differing in work to rest ratio, and examine the CK response to a repeated bout of isometric exercise. Eleven males were tested on two sessions (bouts) spaced 1 week apart. For bout 1, five subjects (group A) performed a forearm flexion isometric exercise consisting of 40 10-s maximal contractions with 20-s inter-trial rests (10:20), while six (group B) performed 40 maximal 10-s contractions with 5-s inter-trial rests (10:5). The increase in serum CK activity following the 10:20 exercise (143%) was significantly greater than that following the 10:5 exercise (52%). The 10:20 exercise was also associated with greater tension generation over trials. One week later, both groups performed a bout of 10:20 exercise. A substantial reduction in the serum CK response was found following this second bout. The data suggest that for bout 1 the isometric exercise associated with the greater overall tension levels resulted in the greater CK response. However, when the 10:20 exercise was repeated 1 week later, a substantial reduction in the CK response was found which was unrelated to the tension generated.

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The consequences of eccentric contractions and their relationship to delayed onset muscle pain

Newham

1988

Europ. J. Appl. Physiol.

131

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Exercise can cause muscle pain for a number of reasons. Usually the pain is experienced during the exercise and recovers rapidly afterwards. There is one type of muscle pain that has a very different and characteristic time course. In this situation the exercise itself, and the immediate post-exercise period are painfree. The pain is not felt for about eight hours and is maximal 1 or 2 days later. Delayed onset muscle pain occurs after unaccustomed, high force contractions and is particularly associated with eccentric contractions. The concensus of opinion is that the pain is caused by some form of damage, but the mechanism for the pain is not known. This review summarises the literature on the consequences of eccentric contractions and relates them to delayed onset muscle pain. There is clear evidence of damage to the muscle fibres themselves, their membranes and, at a later stage, mononuclear cell infiltration, but all these have very different time courses and none are the same as the pain. Intramuscular pressures are raised in some, but not all, painful compartments and even when raised follow a different time course to the pain. Anti-inflammatory agents do not affect the pain, but due to the incomplete understanding of the action of these drugs, the role of inflammation in delayed onset muscle pain is uncertain. Despite the considerable evidence of damage after eccentric contractions, the cause of delayed onset muscle pain is still unknown.

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Serum Creatine Kinase Levels Following Three Different Isometric Exercise Regimens

Cited by 6 publications

References 0 publications

Muscle Soreness and Serum Creatine Kinase Activity Following Isometric, Eccentric, and Concentric Exercise

Muscle Soreness and Serum Creatine Kinase Activity Following Isometric, Eccentric, and Concentric Exercise

Serum creatine kinase activity following forearm flexion isometric exercise

The consequences of eccentric contractions and their relationship to delayed onset muscle pain

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