Muscle Soreness and Serum Creatine Kinase Activity Following Isometric, Eccentric, and Concentric Exercise

Abstract

Serum creatine kinase (CK) activity and subjective ratings of muscle soreness were assessed in 28 college women following three different arm flexion exercise regimens. The subjects were randomly assigned to an eccentric, isometric, or concentric exercise regimen. Each regimen was equated for total work time and work-to-rest ratio. Blood samples for determination of serum CK activity and perceived soreness ratings were obtained prior to and 5, 10, and 25 h following each exercise. Significant increases in perceived soreness ratings were observed for each exercise regimen. The magnitude of the post-exercise increase in perceived soreness was greatest for the eccentric and the isometric exercises with minimal soreness following the concentric exercise. A small but significant increase in serum CK activity was observed following the three exercises (eccentric = 35.8%, concentric = 37.6%, isometric = 34.0%). The post-exercise serum CK increases did not differ significantly among the three regimens. The rise in serum CK activity suggests that muscle damage occurred during all three tasks. However, due to multiple factors which can affect serum CK levels, the increase in serum CK activity may not provide a sensitive indicator of the magnitude of the injury.

Increased incidence of a resonance in the phosphodiester region of 31p nuclear magnetic resonance spectra in the skeletal muscle of fibromyalgia patients

“…That is, eccentric (lengthening) contractions, which have a high force-to-fiber ratio, are the most effective in producing these reactions (18,19), and there is a positive correlation between intensity of eccentric contraction and magnitude of post-exercise alterations (20). Conversely, in FMS patients, high force levels may not be necessary to produce these abnormalities, since even moderate physical activity exacerbates the muscle symptoms (8).…”

Egzersi̇ze Bağli İskelet Ve Kalp Kasi Hasari

“…Literatürdeki çalışmalarda CK miktarının egzersizden 1-5 gün sonra en yüksek seviyesine geldiği bildirilmektedir 10,34,35,36,37 . Yapılan bir çalışmada bacak direnç egzersizinden sonra CK seviyesindeki yükselme 3-4. günlerde en yüksek seviyesine çıkmıştır 36 .…”

“…1986) nın yaptığı çalışmada genç ve yaşlı bayanların bacak fleksörlerine eksantrik kasılma uygulanmış ve CK seviyeleri tespit edilmiştir. Yaşlı bayanların CK seviyeleri 5. günde yüksekliğini korurken genç bayanların CK seviyeleri düşmüştür 37 . Diğer bir çalışmada maratoncularda serum CK miktarı koşu sonrasında öncesine oranla 21 kat daha yüksek bulunmuş ve koşudan 4 gün sonra normal seyrine dönmüştür 35 .…”

Developing Biologically-Based Assessment Tools for Physical Therapy Management of Neck Pain

“…Circulating levels of biomarkers can remain elevated anywhere from a few hours up to 1 to 2 weeks, depending on the magnitude and type of injury, and the biomarker being measured. 24,30,66,69,70,115,120,143 Proteins implicated as potential soft tissue injury biomarkers include the cytoplasmic proteins, creatine kinase (CK) and myoglobin, 24,30,66,69,70,115,120,143 and proteins that make up the contractile apparatus, including myosin and skeletal troponin I. 85,100,101,120,143 Elevated levels of biomarkers have been successfully monitored to indicate muscle damage in other injuries, including intense exercise, trauma, and orthopaedic surgery.…”

“…85,100,101,120,143 Elevated levels of biomarkers have been successfully monitored to indicate muscle damage in other injuries, including intense exercise, trauma, and orthopaedic surgery. 24,30,65,66,85,102,115,120,121,143 Studies on neck injury are absent. Our team is in the process of validating new biomarkers for peripheral muscle injury, starting by using a lumbar surgery model (where the muscle damage can be quantified) to measure the total CK, skeletal muscle CK (CK-MM), IL-6, and Oncostatin M. Our findings indicate that total serum CK peaks between 9 and 48 hours after surgery.…”