Serum creatine kinase level in unmedicated nonpsychotic, psychotic, bipolar and schizoaffective depressed patients

Segal, Michael M.; Avital, Avi; Drobot, Marina; Lukanin, Aida; Derevenski, Andrei; Sandbank, Sergio; Weizman, Abraham

doi:10.1016/j.euroneuro.2006.08.010

Cited by 25 publications

(19 citation statements)

References 33 publications

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“…The literature related to association between CKB levels and depression is controversial in some aspects. The increase in the level of CKB in the serum of non-psychotic major depression patients had been revealed previously in comparison with other types of depression syndromes [42], and in the serum of bipolar disorder patients in manic phase [43]. The activity of this protein was also increased in the PFC of rats after chronic treatment with the antidepressant paroxetine [44].…”

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confidence: 64%

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Proteomic investigation of the prefrontal cortex in the rat clomipramine model of depression

Gellén

Völgyi

Győrffy

et al. 2017

Journal of Proteomics

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confidence: 64%

“…In addition, the level of CKB in serum has been used as a biomarker to differentiate between psychotic and non-psychotic depression patients on a molecular basis [42].…”

mentioning

confidence: 99%

Proteomic investigation of the prefrontal cortex in the rat clomipramine model of depression

Gellén

Völgyi

Győrffy

et al. 2017

Journal of Proteomics

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“…In humans, depression is often comorbid with other chronic diseases and can worsen their associated health outcomes [4]. Previous studies have suggested that the activities of serum enzymes such as creatine kinase (CK) are potentially involved in several types of depression [5,6]. Segal et al investigated the total activity of serum CK in various forms of depression, including major depression with or without psychotic symptoms, bipolar depression, and schizoaffective depression [5].…”

Section: Resultsmentioning

confidence: 99%

“…Previous studies have suggested that the activities of serum enzymes such as creatine kinase (CK) are potentially involved in several types of depression [5,6]. Segal et al investigated the total activity of serum CK in various forms of depression, including major depression with or without psychotic symptoms, bipolar depression, and schizoaffective depression [5]. Their results showed that serum CK activity in nonpsychotic major depression was significantly higher than that in all other forms of depression.…”

Section: Resultsmentioning

confidence: 99%

Depressive symptoms of female nursing staff working in stressful environments and their association with serum creatine kinase and lactate dehydrogenase – a preliminary study

Kato

Sakakibara

Tsuboi

et al. 2014

BioPsychoSocial Med

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BackgroundThe activity of creatine kinase (CK) in serum has recently been reported to be potentially associated with several types of depression. The aim of this study is to evaluate whether serum enzymes, including CK, vary even in a healthy population with depressive symptoms caused by work-related stress. We gave questionnaires and blood examinations to 93 healthy female nursing home workers and did an enzyme-linked immunosorbent assay for the quantitative detection of CK isozyme muscle-type M chain (CK-MM) in serum.FindingsDepressive symptoms were determined using the Center for Epidemiologic Studies Depression (CES-D) scale and compared with the results of the blood examination and serum CK-MM levels. The CES-D results showed significant negative correlations with total CK and lactate dehydrogenase (LDH) activities and CK-MM level (r = -0.29, p = 0.0062; r = -0.29, p = 0.0065; r = -0.33, p = 0.0016, respectively).ConclusionsTotal CK and LDH activities and serum CK-MM level appear to be associated with the depressive symptoms of healthy nurses working in stressful environments, although the significance level was relatively low. The simultaneous detection of serum CK and LDH activities or serum CK-MM level and LDH activity may be useful as an indicator of depressive symptoms, at least for female nursing staff with work-related stress.

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“…Moreover, some work has shown that there is a significant negative correlation between creatine metabolites and selfreported suicidal ideation in patients suffering from major depressive disorders [14]. More recently, it has been found that levels of brain creatine are inversely related to the severity of a depressive episode [34,35]. Phosphorus magnetic resonance spectroscopy has shown increased phosphocreatine and decreased ATP values in the frontal lobe and basal ganglia of depressed subjects [32,33,36,37].…”

Section: Depressionmentioning

confidence: 98%

A Potential Role for Creatine in Drug Abuse?

2011

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Supplemental creatine has been promoted for its positive health effects and is best known for its use by athletes to increase muscle mass. In addition to its role in physical performance, creatine supplementation has protective effects on the brain in models of neuronal damage and also alters mood state and cognitive performance. Creatine is found in high protein foods, such as fish or meat, and is also produced endogenously from the biosynthesis of arginine, glycine, and methionine. Changes in brain creatine levels, as measured using magnetic resonance spectroscopy, are seen in individuals exposed to drugs of abuse and depressed individuals. These changes in brain creatine indicate that energy metabolism differs in these populations relative to healthy individuals. Recent work shows that creatine supplementation has the ability to function in a manner similar to antidepressant drugs and can offset negative consequences of stress. These observations are important in relation to addictive behaviors as addiction is influenced by psychological factors such as psychosocial stress and depression. The significance of altered brain levels of creatine in drug-exposed individuals and the role of creatine supplementation in models of drug abuse have yet to be explored and represent gaps in the current understanding of brain energetics and addiction.

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Serum creatine kinase level in unmedicated nonpsychotic, psychotic, bipolar and schizoaffective depressed patients

Cited by 25 publications

References 33 publications

Proteomic investigation of the prefrontal cortex in the rat clomipramine model of depression

Proteomic investigation of the prefrontal cortex in the rat clomipramine model of depression

Depressive symptoms of female nursing staff working in stressful environments and their association with serum creatine kinase and lactate dehydrogenase – a preliminary study

A Potential Role for Creatine in Drug Abuse?

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