Serum Creatine and Creatinine in Children and Adolescents

Kuhlbäck, B; Pasternack, Amos; Launiala, K; Stenberg, Marianne

doi:10.3109/00365516809160734

Cited by 15 publications

(4 citation statements)

References 11 publications

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“…In addition, serum creatinine concentrations were decreased in obese adolescents compared with normal weight adolescents. It has been suggested that serum creatinine levels depend on age and they could be attributed to blood volume, which is relatively large in proportion to the muscle mass during this period of age [34]; however, there are not differences in age among groups classified according to BMI in this study. In this sense, we recategorize adolescents by MetS, according with the Cook et al, criteria [29], we observed that adolescents with MetS showed lower serum creatinine concentrations compared with those without MetS.…”

Section: Discussioncontrasting

confidence: 65%

Osteopontin’s relationship with malnutrition and oxidative stress in adolescents. A pilot study

et al. 2021

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Osteopontin (OPN) is a protein involved in inflammatory illnesses such as fibrosis and cancer; its overexpression in cardiovascular diseases promotes the biomineralization of blood vessels and other soft tissues. Moreover, there is an active component of oxidative stress related with those diseases. The present study relates serum OPN levels with nutritional condition and oxidative stress in a group of adolescents. Anthropometric measurements were performed, and fasting blood samples were analyzed to determine OPN concentrations, blood chemistry parameters (glucose, triglycerides, total cholesterol, urea, uric acid, and creatinine) and oxidative stress biomarkers (Paraoxonase-1, Glutathione S-Transferase, Catalase, NAD(P)H Quinone Oxidoreductase, free carbonyl groups and malondialdehyde). Adolescents were categorized according to body mass index (BMI) and metabolic syndrome (MetS) criteria. We found increased OPN serum concentrations in overweight and obese adolescents, as well as in adolescents with MetS. Rises in OPN correlated with arm circumference and biomarkers of lipid peroxidation; with regard to serum glucose there was a trend to positive correlation. Our results suggest that serum OPN is associated to nutritional status and could be considered as an early biomarker of low-grade inflammation and probably the early biomineralization of soft tissues in adolescence.

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Section: Discussioncontrasting

confidence: 65%

Osteopontin’s relationship with malnutrition and oxidative stress in adolescents. A pilot study

et al. 2021

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“…The method used in this study is highly reproducible in the laboratory, and measures creatinine with great consistency within the same subject over a period of time. Extensive experience with the method in a large children's renal service has confirmed the impression given by the data presented in this paper-that is, it is a reliable and satisfactory technique that can be relied upon [1][2][3][4][5] which is equivalent to saying that GFR is less than 80 ml/min per 1.73 n2, the prediction of GFR from 4OHt/Pcr is probably good enough for normal clinical purposes. Thus, the net effect of interpreting Pcr in this way is to reduce the number of clearance or other GFR procedures by rather more than half, a very substantial saving in time and resources.…”

Section: Discussionsupporting

confidence: 48%

Evaluation of a height/plasma creatinine formula in the measurement of glomerular filtration rate.

Morris¹,

Allanby²,

Toseland³

et al. 1982

Archives of Disease in Childhood

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SUMMARY The clinical usefulness of the quantity height (cm)/plasma creatinine (Ht/Pcr) as a predictor of glomerular filtration rate (GFR) was investigated in 163 children with varying levels of renal function. Plasma creatinine levels (,umol/l) were measured by an automated reaction rate method. The results indicate that in rather more than half the children studied, an estimate of GFR adequate for ordinary clinical purposes will be obtained from Ht/Pcr, or from the derived formula GFR (ml/min per 1-73 m2) = 4OHt/Pcr. The accuracy of the prediction is greatest in children with reduced function (GFR <80 ml/min per 1 * 73 m2) and in this group of patients a change of GFR of 19 ml/min per 173 m2 or more is reliably detected by this method. We conclude that Ht/Pcr is a clinically useful aid to the estimation of renal function, reducing the need for formal GFR measurements by at least half.

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“…In six infants with bilirubin levels between 120 and 300 Jlmol/L the supernatant contained less than 7% of the original bilirubin, confirming that unconjugated bilirubin is precipitated with albumin by this procedure. The mean creatinine concentration in deproteinised serum (75·2 Jlmol/ L), was not significantly different (P > 0·\) from the mean concentration in untreated serum (77,5 Jlmol/L), in 12 infants aged between 1 day and II days with bilirubin levels between 130 and 320 Jlmol/L. This suggests that the method is not subject to interference from unconjugated bilirubin.…”

Section: Meanmentioning

confidence: 77%

Reference Ranges for Serum Creatinine in Infants, Children and Adolescents

Savory

1990

Ann Clin Biochem

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SUMMARY.Reference ranges for serum creatinine, derived from 2110 cases aged between I day and 20 years, are presented. Levels fall during the neonatal period and then increase with age in both sexes. Levels fall more rapidly in full term infants than in premature infants and are significantly higher in males than in females aged 15 years and above. The aim of this study has been to establish reference ranges for narrow age groups, in infants, children, and adolescents, by analysis of a larger number of cases than previously reported, and to compare data from full term and premature infants. MATERIALS AND METHODSSerum creatinine was measured in 2110 cases aged between 1 day and 20 years. In-patients and out-patients, from whom blood had been received in the laboratory for a wide variety of investigations, were included in the study. Patients with known or suspected renal disease and diabetes mellitus were excluded, but other sick patients were included. Variations in diet and muscle mass were not taken into consideration.Analysis was performed by a direct kinetic measurement, based on the Jaffe procedure," on an IL 508 analyser (Instrumentation Laboratory (UK) Ltd, Warrington, Cheshire, UK). The instrument dispenses 50 JlL sample and 800 JlL alkaline picrate reagent into an optically clear cuvette; a 7 s measurement of absorbance change Correspondence: Mr D J Savory. 99at 500 nm is made after a 12 s mixing and lag phase.Precision studies were performed using bovine-based control sera. Coefficients of variation were 1·8% (intra-batch) and 2·8% (interbatch) at 56 Jlmol/L and 1·7% (intra-batch) and 3·1 % (inter-batch) at 92 Jlmol/L.Patient data was analysed in age groups of 1 year for each sex between the ages of 1 year and 20 years and in narrower groups for infants less than 1 year of age. Neonatal male and female data were combined but data from full term and premature infants « 37 weeks) were analysed separately. Mean and SD were calculated for each age group and then recalculated after exclusion of outliers (> 3·5 SD). Twelve cases were excluded by this procedure. Comparison of means was performed by an unpaired t test. RESULTS Meanvalues and reference ranges (Mean ± 2 SD) for both sexes in each age group from 1 month to 20 years are listed in Table 1. Mean values and reference ranges for full term infants and premature infants are listed in Table 2.Creatinine levels fall during the neonatal period. Thereafter mean levels rise from approximately 45 Jlmol/L in both sexes at 1 year to approximately 85 Jlmol/L in males and 75 Jlmol/L in women at 20 years. Levels are higher in men than in women in all age groups above 8 years and the difference between the sexes is significant (P < 0,05) in all age groups above 14 years. Results from full term and

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Serum Creatine and Creatinine in Children and Adolescents

Cited by 15 publications

References 11 publications

Osteopontin’s relationship with malnutrition and oxidative stress in adolescents. A pilot study

Osteopontin’s relationship with malnutrition and oxidative stress in adolescents. A pilot study

Evaluation of a height/plasma creatinine formula in the measurement of glomerular filtration rate.

Reference Ranges for Serum Creatinine in Infants, Children and Adolescents

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