Serum cortisol of Sahel goats following rumenotomy with assorted anaesthetics and sutures

Saidu, Abubakar Mshelia; Bokko, Paul Bitrus; Abdullahi, Mohammed; Bukbuk, David; Igwenagu, Ephraim

doi:10.1016/j.ijvsm.2016.10.008

Cited by 10 publications

(9 citation statements)

References 5 publications

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“…Surgical stress response involves stimulation of the sympathoadrenal medullary and the hypothalamic-pituitary-adrenal axis [ 9 - 13 ]. Their activation causes endocrine and immunomodulatory changes after trauma [ 14 - 17 ]. The degree of physiological response is proportional to the magnitude of injury with increased demands on organ function [ 18 - 22 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of various surgical procedures on biochemical parameters of Nigerian dogs and their clinical implications

2018

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Aim:The importance of physical and psychological stress caused by pain during surgery cannot be overemphasized. The aim of this study was to assess the effects of ovariohysterectomy (OVH), gastrotomy (GST), and intestinal resection and anastomosis (IRA) on biochemical parameters of Nigerian dogs anesthetized with the xylazine-propofol combination.Materials and Methods:A total of 12 dogs were randomly divided into three groups of four each. The animals were treated with xylazine and propofol anesthetics for OVH, GST, and IRA in Groups 1-3, respectively. Blood samples were collected at 0 h, 2, 24, 48, 72, 96, 120, and 144 h postsurgery for determination of cortisol (CORT), glucose (GLU), total protein (TP), albumin (ALB), globulin (GL), and ALB/GL ratio.Results:There were significant increases (p<0.05) in mean CORT concentrations 2 h postsurgery in the three groups and at 24 h in Group 3 and 96 h in Groups 1 and 3, respectively. GLU concentrations increased significantly (p<0.05) in the three groups at 2 h postsurgery. The mean protein concentrations in Groups 2 and 3 decreased significantly (p<0.05) at 2h and 24 h and 72 h, 96 h, 120 h, and 144 h in Group 3, respectively. There was significant decrease (p<0.05) in the mean ALB concentrations at 2 h, 24 h, 72 h, 96 h, 120 h, and 144 h postsurgery. There was a significant difference (p<0.05) in the mean GL concentrations in Group 3 at 24 h, 72 h, 96 h, and 144 h. All other parameters were not significantly different (p>0.05) in comparison with the control.Conclusion:Xylazine-propofol combination could decrease humoral immune status and increase serum GLU level invariably portending a high risk of diabetes in the vulnerable dogs.

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Section: Introductionmentioning

confidence: 99%

Effects of various surgical procedures on biochemical parameters of Nigerian dogs and their clinical implications

2018

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“…The stress response could stimulate the hypothalamic pituitary adrenal axis, which results in an increase in cortisol release. Cortisol level has been found to significantly increase after surgical stimuli in goats [ 39 ], cattle [ 27 ], dogs [ 40 ], and cats [ 41 ]. In this current study, the XNK group displayed a non-significant increase in cortisol level at TInd, TE (0), and ½, 1 h postoperatively, however the XK group significantly increased the cortisol at the same timepoints compared to baseline.…”

Section: Discussionmentioning

confidence: 99%

Immediate Postoperative Analgesia of Nalbuphine-Ketamine Combination Compared with Ketamine Alone in Xylazine-Sedated Goats Undergoing Left Flank Laparotomy

Abouelfetouh

Salah

Liu

et al. 2022

Animals

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Goats have been used as animal models in research, and the need for achieving safer anesthesia for research or surgical intervention is gaining much attention. The objective of this study was to evaluate intraoperative effects and the immediate postoperative analgesia of nalbuphine–ketamine regimen in goats. Twenty clinically healthy adult female crossbred goats weighing 14 ± 2 kg were allocated randomly into each of two equally sized groups. All animals were sedated with intramuscular (IM) xylazine (0.07 mg/kg), then anesthesia was intravenously (IV) induced with ketamine alone (10 mg/kg) (XK group), or a combination of nalbuphine (0.5 mg/kg) and ketamine (5 mg/kg) (XNK group). Following induction, left flank laparotomy was performed and then sutured. The quality of anesthesia and immediate postoperative analgesia was evaluated. Immediate postoperative analgesia was assessed up to 5 h after standing, using a modified Unesp–Botucatu acute composite pain scale (USAPS). Serum cortisol, glucose, insulin, and C-reactive protein (CRP) were measured at ½, 1, 2, 4, 6, 12, and 24 h, postoperatively (PO). The USAPS pain scores were significantly lower in the XNK compared to the XK group (p < 0.05). The XNK group exhibited a statistically significant difference in the level of serum cortisol at ½ and 1 h PO (p = 0.018 and 0.045, respectively) compared to the XK group. At 2, 4, 6 h PO, CRP significantly decreased (p = 0.023, 0.040 and 0.005, respectively) in the XNK compared to the XK group. Nalbuphine–ketamine produced an acceptable induction of anesthesia and recovery compared to ketamine. Recovery with nalbuphine–ketamine was faster and better quality. The USAPS pain scores were lower in nalbuphine–ketamine, indicating that this novel combination produces better postoperative pain control than ketamine alone.

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“…37 In goats, there was alteration of cortisol after surgery and anesthesia in all groups. 3 Goats are very sensitive to manipulation and anesthesia, animals that do not like routine changes. In thermal stress, they also presented lower cortisol changes for those who underwent exogenous melatonin.…”

Section: Discussionmentioning

confidence: 99%

“…1 Cortisol levels in goats ranges 14-18ngmL. 2 The type of anesthetic block may also influence the amount of blood cortisol in animals, 3 as well as temperature and estrous in goats, interfering directly with exogenous melatonin. 4 The endocrine response is one of the physiological mechanisms to respond to stress in the temperature levels and is a mechanism of homeostasis defense, increases with body temperature, however melatonin regulates the level of cortisol.…”

Section: Introductionmentioning

confidence: 99%

Melatonin, cortisol and progesterone in alpine goat’s superstimulateds with FSH-OV and artificial photoperiod

Monreal¹,

Garcia²,

Toniollo³

2018

JAPLR

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Background: It is already well known the importance of hormones such as progesterone, cortisol and melatonin on the reproduction of females of various species. However, as regards the goat species, there is still a lack of data, especially in animals used in oocyte donation programs for subsequent in vitro production of embryos. The objective of this study was to verify the profile of progesterone, cortisol and melatonin during the hormonal treatment of ovarian stimulation in the anestrous, transition and reproductive season in Alpine goats using artificial and natural photoperiod. Seventeen female Alpine goats were reared at latitude 21°15'22''S. The animals were treated with 10mg oFSH (Ovagen, ICP, New Zealand) in decreasing doses for four consecutive days at the end of a progestin treatment with CIDR® (Intervet, New Zealand) at the reproductive season (G1,n=7) and anestrous with artificial photoperiod (G2,n=5) or natural (G3,n=5). Blood samples were taken before, during and after the period of ovarian stimulation and during oocyte harvest by laparotomy. Blood collection for melatonin was performed overnight, for progesterone and cortisols were performed for 16days in the morning. The values were presented as mean, standard deviation and median for the groups and compared by non-parametric analysis (Kruskal-Wallis, analysis of variance and Friedman). With regard to progesterone, there was a difference (P<0.05) between the three groups studied and in the two periods (reproductive season/anestrous), with higher values in the reproductive season. Statistical differences (P>0.05) were not observed for cortisol between groups, however, after laparotomy there was a significant increase (P<0.05) in the operated goats (G1:40.94±18,53nmol/L) compared to those not operated at the reproductive season (G2:17.86±14.90nmol/L and G3:16.00±16.51nmol/L). Serum cortisol values were lower than those of the reproductive season for all groups, G1(13.18±9.43nmol/L, natural photoperiod, non-laparotomized goats), G2(26,70±15,39nmol/L, artificial photoperiod, laparotomized goats) and G3 (35.35±17.10nmol/L, natural photoperiod, laparotomized goats). However, the surgical group (G2 in artificial photoperiod) presented serum cortisol levels between the nonsurgical group (G1 in the natural photoperiod) and the surgical group (G3 in the natural photoperiod), leading to the belief that melatonin might have interfered with the values Cortisol of these animals in anestrus. During the experimental period, melatonin values were always high in all groups in the anestrous period (G1:68.19pg/mL, G2: 45.53pg/mL and G3:58.28pg/mL). Conclusion: Under the conditions of this study, it is possible to verify an influence of the season (reproductive or anestrous), and possibly melatonin, on the secretion of cortisol in these animals.

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Serum cortisol of Sahel goats following rumenotomy with assorted anaesthetics and sutures

Cited by 10 publications

References 5 publications

Effects of various surgical procedures on biochemical parameters of Nigerian dogs and their clinical implications

Effects of various surgical procedures on biochemical parameters of Nigerian dogs and their clinical implications

Immediate Postoperative Analgesia of Nalbuphine-Ketamine Combination Compared with Ketamine Alone in Xylazine-Sedated Goats Undergoing Left Flank Laparotomy

Melatonin, cortisol and progesterone in alpine goat’s superstimulateds with FSH-OV and artificial photoperiod

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