Serum corticosterone elevation by pergolide in rats: prevention of tolerance development by spiperone

Fuller, Ray W.; Snoddy, Harold D.

doi:10.1111/j.2042-7158.1982.tb04808.x

Cited by 4 publications

(1 citation statement)

References 4 publications

(7 reference statements)

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“…These rats responded to quipazine with a normal increase in serum corticosterone concen tration, indicating their pituitary-adrenocortical axes were fully responsive and that the tolerance to pergolide might be related to adaptive changes in dopamine receptor mecha nisms. Further support for that idea came from the finding that co-treatment with spiperone prevented the develop ment of tolerance to pergolide [9], The present findings that rats pretreated with four daily injections of pergolide show a markedly attenuated response to LY141865 support the idea that LY 141865 and pergolide are both acting through activation of a common receptor (presumably a dopamine receptor) to increase corticosterone concentration. Since pergolide-pretreated rats do respond to quipazine [8], a se rotonin agonist, these data further rule out an involvement of serotonin receptors in the action of pergolide and LY141865.…”

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confidence: 69%

Elevation of Serum Corticosterone in Rats by Dopamine Agonists Related in Structure to Pergolide

et al. 1983

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Two chemical analogs of pergolide were examined to test further the idea that pergolide elevates serum corticosterone concentration in rats by activation of brain dopaminergic receptors. LY116467, which contains an N-methyl substituent in place of the N-n-propyl substituent in pergolide, was less potent than pergolide in lowering brain levels of 3,4-dihydroxyphenylacetic acid (Dopac), the metabolite of dopamine. LY 116467 increased serum corticosterone concentration in rats at a dose of 3 mg/kg (a higher dose than is required for pergolide), and the effect was prevented by spiperone pretreatment. LY141865, which has been reported to differ from pergolide in not activating dopamine-sensitive adenylate cyclase and which was found in this study to have much less affinity for serotonin receptors than does pergolide, increased serum corticosterone in much the same manner as pergolide, only slightly higher doses being required. The effect of LY141865 was prevented by pretreatment with haloperidol but not domperidone. Both haloperidol and domperidone increased serum prolactin concentration when given alone or in combination with LY141865, indicating they were both capable of blocking peripheral (pituitary) dopamine receptors. In contrast, haloperidol but not domperidone caused a marked elevation in brain levels of Dopac and of homovanillic acid and prevented the lowering of these brain dopamine metabolites by LY141865. The ability of LY141865 to increase serum corticosterone concentration was attenuated in rats that had received four daily injections of pergolide mesylate, indicating cross-tolerance had occurred. These results strengthen the hypothesis that activation of brain dopaminergic receptors leads to increased serum corticosterone concentration in rats.

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Section: Discussionsupporting

confidence: 69%

Elevation of Serum Corticosterone in Rats by Dopamine Agonists Related in Structure to Pergolide

et al. 1983

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Dopaminerge Wirkung von Anisodamin auf die renale Mikrozirkulation der gespaltenen hydronephrotischen Rattenniere

Ap¹,

Parekh

Steinhausen

1991

Journal of Tongji Medical University

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Anisodamine is an alkaloid extracted from the Tibetan plant "Anisodus tanguticus". Since 1965 it has been used in China for the treatment of shock but the mechanisms of its action are not fully known. The present study was performed to determine the effect of anisodamine on the renal microcirculation and to examine the underlying mechanism of its actions. The addition of anisodamine (10(-8) M to 10(-3) M) to the kidney bath resulted in a significant and dose dependent dilation of all preglomerular vessels. The maximal dilation (about 30% dilation) was found in the proximal interlobular artery. In contrast to preglomerular vessels anisodamine caused constriction of postglomerular vessels. The glomerular blood flow increased by about 50% at anisodamine concentration of 10(-3) M. Haloperidol, a dopamine receptor antagonist could abolish the renal vascular effect of anisodamine. It is suggested that anisodamine could improve renal function by the dilation of preglomerular vessels in combination with the constriction of postglomerular vessels, and the effect of anisodamine may be mediated by activation of the dopaminergic system.

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Central dopamine receptors mediating pergolide-induced elevation of serum corticosterone in rats

Fuller

Snoddy

1984

Neuropharmacology

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Serum corticosterone elevation by pergolide in rats: prevention of tolerance development by spiperone

Cited by 4 publications

References 4 publications

Elevation of Serum Corticosterone in Rats by Dopamine Agonists Related in Structure to Pergolide

Elevation of Serum Corticosterone in Rats by Dopamine Agonists Related in Structure to Pergolide

Dopaminerge Wirkung von Anisodamin auf die renale Mikrozirkulation der gespaltenen hydronephrotischen Rattenniere

Central dopamine receptors mediating pergolide-induced elevation of serum corticosterone in rats

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