Serum Copper and Zinc Levels in Various Pathologic Conditions

Sinha, Surendra Nath; Gabrieli, E. R.

doi:10.1093/ajcp/54.4.570

Cited by 122 publications

(36 citation statements)

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“…Low plasma zinc and high plasma copper have been observed in different liver dis eases such as human alcoholic liver cirrhosis, viral hepatitis and CCl4-induced cirrhosis in rats [Vallee et al, 1956;Sinha and Gabrieli, 1970;Dashti et al, 1984;Henkin and Smith, 1972;Kahn and Ozeran, 1967]. We also found decreased plasma zinc levels in CC14 and thioacetamide-induced cirrhotic rats.…”

Section: Discussionsupporting

confidence: 75%

Thioacetamide- and Carbon Tetrachloride-Induced Liver Cirrhosis

Dashti¹,

Jeppsson²,

Hägerstrand³

et al. 1989

Eur Surg Res

121

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Two methods of inducing liver cirrhosis in the rat were studied. Intragastric administration of CCl₄ for 16 weeks according to Proctor and Chatamra was compared to the administration of thioacetamide in the drinking water (0.3 g/l) for the same period. CCl₄ administration induced micronodular cirrhosis in 6/8 animals with a 27% mortality. Thioacetamide induced cirrhosis in 6/8 animals without mortality. The histologic pictures differed somewhat in that the CCl₄ group exhibited more necrosis and cellular swelling while the thioacetamide group had more nuclear atypias and proliferation. Biochemically both groups had elevated plasma levels of aspartate aminotransferase. The lysosomal enzyme β-hexosaminidase (β-NAG) showed a transient increase in the thioacetamide animals, while β-glucuronidase decreased. CCU-induced cirrhosis led to an increase in β-NAG. Plasma zinc decreased in both groups as well as liver zinc content in the CCl₄ group, while there was a continuous elevation of liver zinc in the thioacetamide group. We conclude that oral administration of thioacetamide is a simple and reliable method of inducing experimental liver cirrhosis. The differences in histological appearances and some biochemical parameters may be caused by the different mechanisms of action of thioacetamide and CCl₄.

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Section: Discussionsupporting

confidence: 75%

Thioacetamide- and Carbon Tetrachloride-Induced Liver Cirrhosis

Dashti¹,

Jeppsson²,

Hägerstrand³

et al. 1989

Eur Surg Res

121

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“…Statistically there was no difference in mean serum zinc levels among males and females (p = 0.773). The current data demonstrated that there is a insignificant week positive correlation between zinc (mg/l) and age of patients in the study group, this result agree with the result observed by Sinha and Gabrieli 1970 (14) . Who analyzed serum zinc levels in 200 apparently healthy volunteers (100 males, 100 females) to establish their normal range.…”

Section: Discussionsupporting

confidence: 92%

Assessment of Serum Zinc level in Sudanese Patients with Chronic Tonsillitis Infection in Khartoum State

Mohamed¹

2017

JMSCR

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“…Also serum copper and ceruloplasmin (an acute phase reactant synthesized in the liver) have been reported to be useful markers of disease activity in patients with carcinoma of the breast, lung, gastrointestinal tract. acute leukemias and Hodgkin's and nonHodgkin's lymphoma (8)(9)(10) elevated in non-malignant conditions, such as pregnancy, thyrotoxicosis, cirrhosis, and infections ( 1 I).…”

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confidence: 99%