Ceruloplasmin Level in Women with Breast Disease Preliminary Results

Özyılkan, Ö; Baltali, E; Özyılkan, E; Tekuzman, Gülten; Kars, Ayse; Firat, D.

doi:10.3109/02841869209089716

Cited by 14 publications

(11 citation statements)

References 14 publications

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“…They also showed that the ceruloplasmin levels of patients with breast carcinoma increased 16-34 weeks before their metastases became clinically overt. In our previous study, we suggested that ceruloplasmin could be used as a tumour marker for the follow up of breast cancer patients (21). In the present study, we again found serum ceruloplasmin levels valuable in detecting active breast cancer.…”

Section: Distribution Of Serum Tps Levels In Patients With Active Bresupporting

confidence: 81%

CA 15-3, Ceruloplasmin and tissue polypeptide specific antigen as a tumour marker panel in breast cancer

Özyılkan

Baltali²,

Kirazlı³

2009

E Af Med Jrnl

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The difference between the patients in remission, BBD and the control group was not statistically significant (p>0.05) for CA 15-3 and ceruloplasmin. The difference for TPS between the patients in remission and the patients with active breast cancer was not statistically significant (p>0.05). The sensitivities of CA 15-3, ceruloplasmin, and TPS for detecting active breast cancer were 75.0%, 75.0%, and 78.0%, respectively. Conclusion: The highest sensitivity for active breast cancer detection was obtained by the combined use of three tumour markers. We concluded that there may be an advantage in using panels in the follow up of breast cancer patients, although so far such tests have too low a specificity to be of practical value in screening.

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Section: Distribution Of Serum Tps Levels In Patients With Active Bresupporting

confidence: 81%

CA 15-3, Ceruloplasmin and tissue polypeptide specific antigen as a tumour marker panel in breast cancer

Özyılkan

Baltali²,

Kirazlı³

2009

E Af Med Jrnl

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“…In this study, it was suggested that the low ratio of copper/ceruloplasmin could be associated with advanced stage (Vaidya et al, 1998). In patients with breast cancer, ceruloplasmin level was found to be high and associated with bad prognosis (Ozyilkan et al, 1992;Arumanayagam et al, 1993). In our study, ceruloplasmin levels were not found to be different with regards to benign-malign pathologies.…”

Section: Discussionsupporting

confidence: 51%

Roles for Paraoxonase but not Ceruloplasmin in Peritoneal Washing Fluid in Differential Diagnosis of Gynecologic Pathologies

Yıldırım¹,

Demirpençe²,

Kaya³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…50 Moreover, ceruloplasmin levels are increased in the serum of patients with breast cancer. 51 It has been proposed that ceruloplasmin transports iron into malignant cells. 50 Ceruloplasmin was expressed in most of the human cell lines that we stained.…”

Section: Discussionmentioning

confidence: 99%

cDNA microarray analysis of invasive and tumorigenic phenotypes in a breast cancer model

Kluger

Gilmore-Hebert

et al. 2004

Laboratory Investigation

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The fms oncogene encodes the macrophage colony-stimulating factor receptor (CSF1R), a transmembrane tyrosine kinase receptor, which is abnormally expressed in breast cancer. Transfection of wild-type CSF1R into HC11 mammary epithelial cells (HC11-CSF1R) renders the transfectants capable of in vitro local invasion and in vivo tumorigenesis. Transfection with CSF1R mutated to express phe at the tyr-721 autophosphorylation site (HC11-CSF1R-721) creates a phenotype that lacks metastastic competence but maintains local invasiveness. Conversely, HC11 cells transfected with CSF1R mutated at tyr-807 (HC11-CSF1R-807) retain their metastatic competence, but are not locally invasive. Our aims were to determine which genes were differentially expressed with transfection of HC11 with wild-type CSF1R, and to determine the effect of mutation at the autophosphorylation sites on gene expression, using 4.6 K cDNA microarrays. Complementary DNA from HC11, HC11-CSF1R-721 and HC11-CSF1R-807 were each hybridized together with HC11-CSF1R on individual arrays. A principal component spectral method combined with prenormalization procedures was used for sample clustering. Differentially expressed genes were identified by the analysis of variance. Confirmation by Northern blotting was performed for MAP kinase phosphatase-1, WDNM1 (extracellular proteinase inhibitor), Trop 2 (tumor-associated calcium signal transducer-2), procollagen type IV alpha, secretory leukoprotease inhibitor, prenylated snare protein Ykt6, ceruloplasmin and chaperonin 10. Many of these genes have not previously been associated with tumor invasion and metastasis. We have successfully identified genes that can be linked to the invasive phenotypes or to tumorigenesis. These genes provide a basis for further studies of metastatic progression and local invasiveness, and can be evaluated as therapeutic targets. The cfms proto-oncogene encodes the only known receptor for the macrophage colony-stimulating factor (CSF1). CSF1R is a transmembrane tyrosine kinase receptor, and its ligand, CSF1, has soluble, membrane-bound and cell matrix-associated isoforms. 1-3 The CSF1R/CSF1 receptor/ligand pair has essential physiologic functions in monocyte and macrophage differentiation, 4,5 embryonic implantation and placental development, and lactogenic differentiation of the human breast. 6-8 Abnormally high CSF1R expression has clinically been associated with aggressive breast, ovarian, endometrial, and prostate cancer. [9][10][11][12][13][14][15][16] Most invasive breast carcinoma cells express readily detectable levels of activated CSF1R. 13 Studies 17 have shown that invasive breast cancer cells coexpress the ligand CSF 1, but adjacent in situ carcinoma cells do not. Moreover, in early-stage breast cancer patients treated with local therapy only, high levels of CSF1R expression also have been associated with a higher likelihood of ipsilateral recurrence. 18 To further evaluate the role of CSF1R in invasion and metastasis, we studied a mouse cell line model 19 that utilized the HC11...

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Ceruloplasmin Level in Women with Breast Disease Preliminary Results

Cited by 14 publications

References 14 publications

CA 15-3, Ceruloplasmin and tissue polypeptide specific antigen as a tumour marker panel in breast cancer

CA 15-3, Ceruloplasmin and tissue polypeptide specific antigen as a tumour marker panel in breast cancer

Roles for Paraoxonase but not Ceruloplasmin in Peritoneal Washing Fluid in Differential Diagnosis of Gynecologic Pathologies

cDNA microarray analysis of invasive and tumorigenic phenotypes in a breast cancer model

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