Serum copper and zinc concentrations in patients with chronic hepatitis B

Cesur, Salih; Cebeci, Sevsen; Kavas, Güzin Özelçi; Aksaray, Sebahat; Tezeren, Deniz

doi:10.1016/j.jinf.2004.08.012

Cited by 17 publications

(12 citation statements)

References 6 publications

(8 reference statements)

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“…Several small studies have evaluated serum zinc levels in patients with chronic viral hepatitis. [69][70][71][72][73][74] The results have been mixed. Three found no significant differences when compared with controls; however, others have demonstrated a signifi-cant decrease in serum zinc levels when compared with controls.…”

Section: Zinc In Viral Hepatitismentioning

confidence: 99%

“…Three found no significant differences when compared with controls; however, others have demonstrated a signifi-cant decrease in serum zinc levels when compared with controls. [69][70][71][72][73][74] In one of these studies, a significant difference was found only in those patients with cirrhosis. 72 Another of these studies only looked at patients with chronic hepatitis C and demonstrated that, in addition to lower serum zinc levels at baseline, these reductions were exacerbated further following injection of INF-α.…”

Section: Zinc In Viral Hepatitismentioning

confidence: 99%

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The Use of Selected Nutrition Supplements and Complementary and Alternative Medicine in Liver Disease

et al. 2006

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Section: Zinc In Viral Hepatitismentioning

confidence: 99%

Section: Zinc In Viral Hepatitismentioning

confidence: 99%

The Use of Selected Nutrition Supplements and Complementary and Alternative Medicine in Liver Disease

et al. 2006

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“…Many studies have been conducted to examine the relationship between serum Cu and serum Zn levels and various diseases, especially infectious diseases. 1,2,4,5,7,8,10,11,13,14,18 This is the first study that compares the serum Cu/Zn ratios in patients with brucellosis and individuals in two different control groups. In general, there are two types of abnormalities in the levels of trace elements.…”

Section: Discussionmentioning

confidence: 99%

“…4,5,12 Different studies have investigated the diagnostic value or metabolic alterations of Cu and Zn, particularly in infectious diseases. 1,2,4,5,11,13,14 Brucellosis is a zoonotic infectious disease that is endemic in the Southeastern region of Turkey. The morbidity of disease is rather high, while its mortality is very low.…”

mentioning

confidence: 99%

Alterations of Serum Copper and Zinc Levels, and Copper/Zinc Ratios Among Patients with Brucellosis

Üstün¹,

Teğin²,

Geyik³

2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To determine the alterations of serum copper (Cu) and zinc (Zn) levels and Cu/Zn ratio in patients with brucellosis. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A total of 170 individuals were included in the study. Of these, 45 (26.5%) currently had acute or sub-acute brucellosis, 35 (20.6%) were previously diagnosed with acute or sub-acute brucellosis and successfully treated, and 90 (52.9%) were healthy volunteers. After fasting overnight for 10 hours, 5 ml of venous blood was taken.from all subjects. Serum Cu and Zn levels were measured using a Unicam 929 Atomic Absorption Spectrophotometer. SPSS 16.0 was used for data analysis. R Re es su ul lt ts s: : Mean serum Cu levels of 45 patients with acute or sub-acute brucellosis, 35 patients previously diagnosed with acute or sub-acute brucellosis and 90 healthy volunteers were 88.6±26, 58.7±13 and 56.7±16 µg/dL, respectively. Mean serum Zn levels of 45 patients with acute or sub-acute brucellosis, 35 patients previously diagnosed with and treated successfully for acute or sub-acute brucellosis and 90 healthy volunteers were 38.3±12, 58.5±14, and 55.8±13 µg/dL, respectively. Serum Cu levels (p<0.001) and Cu/Zn ratios (p<0.001) were statistically significantly higher while serum Zn levels (p<0.001) were lower in patients with acute or sub-acute brucellosis when compared to the individuals who previously diagnosed with acute or sub-acute brucellosis and the healthy volunteers. C Co on nc cl lu us si io on n: : This study revealed significant alterations of serum Cu and Zn levels, and Cu/Zn ratios in patients with acute or sub-acute brucellosis. Serum Cu, Zn, and Cu/Zn ratios may be available biomarkers in the course of acute or sub-acute brucellosis.K Ke ey y W Wo or rd ds s: : Brucellosis; copper; zinc; trace elements; serum; biological markers Ö ÖZ ZE ET T A Am ma aç ç: : Brusellozlu hastalarda serum bakır (Cu) ve çinko (Zn) düzeylerinde ve bakır/çinko oranlarındaki değişiklikleri saptamaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: Çalışmaya toplam 170 birey alındı. Bunların 45'i (26,5%) akut veya sub-akut bruselloz hastası, 35'i (20,6%) daha önce akut veya subakut bruselloz tanısı aldıktan sonra başarılı bir şekilde tedavi edilmiş hastalar ve 90'ı (52,9%) sağlıklı gönüllüler idi. Tüm deneklerden 10 saatlik gece açlığını takiben 5 ml venöz kan alındı. Serum Cu ve Zn düzeyleri Unicam 929 Atomik Absorbsiyon Spektrofotometresi ile ölçüldü. Verilerin incelenmesinde SPSS 16.0 kullanıldı. B Bu ul lg gu ul la ar r: : Akut veya sub-akut brusellozlu 45 hastanın, daha önce akut veya sub-akut bruselloza yakalanan 35 hastanın ve 90 sağlıklı gönüllünün ortalama serum Cu düzeyleri sırasıyla 88,6±26, 58,7±13 ve 56,7±16 µg/dL idi. Akut veya sub-akut brusellozlu 45 hastanın, daha önce akut veya sub-akut bruselloza yakalanan 35 hastanın ve 90 sağlıklı gönüllünün ortalama serum Zn düzeyleri sırasıyla 38,3±12, 58,5±14, ve 55,8±13 µg/dL idi. Daha önce akut veya sub-akut bruselloza yakalananlarla ve s...

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“…However, the pattern of trace element changes is not the same in different infections. For example, clinical studies in patients with brucellosis show changes in Cu and Zn (Cesur et al, 2005c), whereas hepatitis B (Cesur et al, 2005a) and C (Cesur et al, 2005b) infections does not affect these elements. The most consistent responses include a decrease in plasma levels of Fe and Zn and an increase in Cu (Beisel, 1998;Ilback et al, 2003b;Pekarek and Engelhardt, 1981).…”

Section: Changed Metabolism In Infectionmentioning

confidence: 99%

Interactions Among Infections, Nutrients and Xenobiotics

Ilbäck

Friman

2007

Critical Reviews in Food Science and Nutrition

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During recent years there have been several incidents in which symptoms of disease have been linked to consumption of food contaminated by chemical substances (e.g., 2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD). Furthermore, outbreaks of infections in food-producing animals have attracted major attention regarding the safety of consumers, e.g., Bovine Spongiform Encephalitis (BSE) and influenza in chicken. As shown for several xenobiotics in an increasing number of experimental studies, even low-dose xenobiotic exposure may impair immune function over time, as well as microorganism virulence, resulting in more severe infectious diseases and associated complications. Moreover, during ongoing infection, xenobiotic uptake and distribution are often changed resulting in increased toxic insult to the host. The interactions among infectious agents, nutrients, and xenobiotics have thus become a developing concern and new avenue of research in food toxicology as well as in food-borne diseases. From a health perspective, in the risk assessment of xenobiotics in our food and environment, synergistic effects among microorganisms, nutrients, and xenobiotics will have to be considered. Otherwise, such effects may gradually change the disease panorama in society.

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Serum copper and zinc concentrations in patients with chronic hepatitis B

Cited by 17 publications

References 6 publications

The Use of Selected Nutrition Supplements and Complementary and Alternative Medicine in Liver Disease

The Use of Selected Nutrition Supplements and Complementary and Alternative Medicine in Liver Disease

Alterations of Serum Copper and Zinc Levels, and Copper/Zinc Ratios Among Patients with Brucellosis

Interactions Among Infections, Nutrients and Xenobiotics

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