Alterations of Serum Copper and Zinc Levels, and Copper/Zinc Ratios Among Patients with Brucellosis

Abstract

A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To determine the alterations of serum copper (Cu) and zinc (Zn) levels and Cu/Zn ratio in patients with brucellosis. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A total of 170 individuals were included in the study. Of these, 45 (26.5%) currently had acute or sub-acute brucellosis, 35 (20.6%) were previously diagnosed with acute or sub-acute brucellosis and successfully treated, and 90 (52.9%) were healthy volunteers. After fasting overnight for 10 hours, 5 ml of venous blood was taken.from all subjects. Serum Cu and Zn levels were measured using a Unicam 929 Atomic Absorption Spectrophotometer. SPSS 16.0 was used for data analysis. R Re es su ul lt ts s: : Mean serum Cu levels of 45 patients with acute or sub-acute brucellosis, 35 patients previously diagnosed with acute or sub-acute brucellosis and 90 healthy volunteers were 88.6±26, 58.7±13 and 56.7±16 µg/dL, respectively. Mean serum Zn levels of 45 patients with acute or sub-acute brucellosis, 35 patients previously diagnosed with and treated successfully for acute or sub-acute brucellosis and 90 healthy volunteers were 38.3±12, 58.5±14, and 55.8±13 µg/dL, respectively. Serum Cu levels (p<0.001) and Cu/Zn ratios (p<0.001) were statistically significantly higher while serum Zn levels (p<0.001) were lower in patients with acute or sub-acute brucellosis when compared to the individuals who previously diagnosed with acute or sub-acute brucellosis and the healthy volunteers. C Co on nc cl lu us si io on n: : This study revealed significant alterations of serum Cu and Zn levels, and Cu/Zn ratios in patients with acute or sub-acute brucellosis. Serum Cu, Zn, and Cu/Zn ratios may be available biomarkers in the course of acute or sub-acute brucellosis.K Ke ey y W Wo or rd ds s: : Brucellosis; copper; zinc; trace elements; serum; biological markers Ö ÖZ ZE ET T A Am ma aç ç: : Brusellozlu hastalarda serum bakır (Cu) ve çinko (Zn) düzeylerinde ve bakır/çinko oranlarındaki değişiklikleri saptamaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: Çalışmaya toplam 170 birey alındı. Bunların 45'i (26,5%) akut veya sub-akut bruselloz hastası, 35'i (20,6%) daha önce akut veya subakut bruselloz tanısı aldıktan sonra başarılı bir şekilde tedavi edilmiş hastalar ve 90'ı (52,9%) sağlıklı gönüllüler idi. Tüm deneklerden 10 saatlik gece açlığını takiben 5 ml venöz kan alındı. Serum Cu ve Zn düzeyleri Unicam 929 Atomik Absorbsiyon Spektrofotometresi ile ölçüldü. Verilerin incelenmesinde SPSS 16.0 kullanıldı. B Bu ul lg gu ul la ar r: : Akut veya sub-akut brusellozlu 45 hastanın, daha önce akut veya sub-akut bruselloza yakalanan 35 hastanın ve 90 sağlıklı gönüllünün ortalama serum Cu düzeyleri sırasıyla 88,6±26, 58,7±13 ve 56,7±16 µg/dL idi. Akut veya sub-akut brusellozlu 45 hastanın, daha önce akut veya sub-akut bruselloza yakalanan 35 hastanın ve 90 sağlıklı gönüllünün ortalama serum Zn düzeyleri sırasıyla 38,3±12, 58,5±14, ve 55,8±13 µg/dL idi. Daha önce akut veya sub-akut bruselloza yakalananlarla ve s...