Serum copper and erythrocyte superoxide dismutase in rheumatoid arthritis.

Banford, Jamie; Brown, D. H.; Hazelton, R. A.; McNeil, Calum J.; Sturrock, R D; Smith, W. Ewen

doi:10.1136/ard.41.5.458

Cited by 60 publications

(11 citation statements)

References 23 publications

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“…Our findings suggested that the levels of eMDA and the activity of eSOD were increased in RA patients, consistent with most of the previous studies (23,32). On the other hand, Banford et al (33) reported a significant decrease in eSOD activity in RA patients. In our study, the levels of eMDA and eSOD were significantly higher in the patients with moderate or severe activity.…”

Section: Discussionsupporting

confidence: 82%

Relationship of Cellular Oxidant and Antioxidant Status with Disease Activity in Patients with Rheumatoid Arthritis

Kocabaş

Büyükbaş

et al. 2010

Turk J Rheumatol

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ÖzetAmaç: Son yıllarda romatoid artrit (RA) gibi inflamatuvar artritlerin patogenezinde reaktif oksijen metabolitlerinin rolüne ilgi oldukça artmıştır. Bizim bu çalışmamızdaki amaçlarımız RA hastalarında plazma ve özellikle eritrositlerdeki oksidan ve antioksidan statüyü araştırmak ve bu statünün hastalık aktivite indeksi (DAS) 28'e göre ılımlı, orta ve şiddetli olarak ayrılan hastalık aktivitesi ile ilişkisini belirlemektir. Yöntem ve Gereçler: Elli RA hastası ve 26 kontrolden alınan açlık kan örneklerinde plazmada ve eritrosit içinde malondialdehit (MDA), ksantin oksidaz (XO), ve superoksit dismutaz (SOD) değer-lerine bakıldı. Hastalık aktivitesinin değerlendirilmesinde ise Hastalık Aktivite Skoru (DAS)-28 kullanıldı. Bulgular: Romatoid artrit hastalarında MDA ve XO'nun plazma seviyeleri ile MDA ve SOD'nin eritrosit seviyeleri kontrol grubundan anlamlı derecede fazla idi. Her ne kadar MDA'nın plazma seviyeleri ılımlı ve orta, eritrosit seviyeleri ise ılımlı aktivite grubunda kontrollerden farklı değilse de (p>0.05) plazma seviyeleri şiddetli (p=0.001), eritrosit seviyeleri hem orta (p<0.001) hem de şiddetli RA hastalarında (p<0.001) anlamlı olarak yüksekti. RA hastalarında plazma SOD seviyeleri anlamlı yükseklik göstermese de (p=0.241) eritrosit SOD seviyelerinde anlamlı bir artış vardı (p<0,001). Eritrosit SOD aktivitesindeki bu artış ılımlı RA'da anlamlı olmasa da orta ve şiddetli RA'da oldukça anlamlıydı (sıra-sıyla p=0.002 and p<0.001). Sonuç: Çalışmamızda bulduğumuz sonuçlar özellikle şiddetli hastalık aktivitesi bulunan RA hastalarında artan plazma ve eritrosit MDA seviyelerinin inflamasyona bağlı olarak oksidatif stresi artır-dığını göstermektedir. Bununla birlikte özellikle orta ve şiddetli aktivitesi olan RA hastalarındaki eritrosit SOD aktivitesindeki artış ile bu strese en azından hücresel seviyede karşı koymaya çalışıldığını öne sürebiliriz. (Turk J Rheumatol 2010; 25: 141-6)

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Section: Discussionsupporting

confidence: 82%

Relationship of Cellular Oxidant and Antioxidant Status with Disease Activity in Patients with Rheumatoid Arthritis

Kocabaş

Büyükbaş

et al. 2010

Turk J Rheumatol

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“…36 Among the enzymatic systems of protecting the cell against free radical injury, SOD and GSHPx play a crucial role in the final detoxication of H 2 O 2 to H 2 O. In present study antioxidant enzymes SOD and GSH-Px levels were statistically significant lower in RA patients compared to healthy controls (Table 3 and Figure 2), this agrees with Nivsarkar and Banford et al 10,37 There are controversial reports on erythrocyte SOD and GSHPx activities in patients with RA, as increased and unaltered, SOD activity has been reported. 9,11 During phagocytosis granulocytes and macrophages produce large amounts of O 2-and H 2 O 2 .…”

Section: Discussionsupporting

confidence: 82%

Status of oxidants and antioxidants in rheumatoid arthritis patients of north Karnataka

2016

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Background: Oxidant stress as a result of increased production of reactive oxygen species (ROS) or a reduction in the body’s endogenous antioxidant defense system is a hallmark of chronic inflammatory diseases including rheumatoid arthritis (RA). The objective of the study was to establish the status of oxidative/nitrosative stress in RA patients of north Karnataka.Methods: Thirty RA patients and equal number of healthy individuals (controls) were included in the study. The morning stiffness (MS) and disease activity score 28 (DAS28) of RA patients were examined. Erythrocyte sedimentation rate (ESR) and hemoglobin (Hb) levels were estimated. Biochemical parameters uric acid, lipid peroxide (LPO), nitric oxide (NOx), vitamin C & E, erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured.Results: Significant increased ESR (11.20 mm/hr vs. 40.97 mm/hr, 265.80%), uric acid (3.85 mg/dL vs. 6.73 mg/dL, 74.81%), LPO (1.12 μmol/L vs. 2.35 μmol/L, 109.82%) and NOx (16.19 μmol/L vs. 45.43 μmol/L, 180.61%) levels with significant decreased of the levels of Hb (12.59 g/dL vs. 10.16 g/dL, 19.30%), vitamin C & E (11.20.mg/L vs. 3.87.mg/dL, 65.45% and 13.01 mg/L vs. 7.05 mg/dL, 45.81%), SOD (3757.90 U/g Hb vs. 2201.20 U/g Hb, 41.42%) and GSH-Px (1.81 U/g Hb vs. 0.92 U/g Hb, 49.17%) were observed in RA. There was direct correlation found between MS, DAS-28 and ESR with serum LPO and NOx in RA patients. A significant negative correlation was detected between activity parameters with biochemical parameters in RA patients.Conclusions: Increased oxidants level and decreased non-enzymatic/enzymatic antioxidants level in RA patients of north Karnataka confirm an association between oxidative/nitrosative stress and rheumatoid arthritis.

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“…Many copper-containing compounds may mimic the cupriprotein superoxide dismutase in destroying superoxide anions [37] and, moreover, extensive evidence indicates that free radicals and free radical products are involved in the pathogenesis of inflammatory disorders [38]. In this context it has been found that (1) the enzyme superoxide dismutase is effective in controlling joint swelling in rheumatoid arthritis [39]; (2) the polymorphonuclear leucocytes isolated from children affected by rheumatoid arthritis generate more superoxide anions and display less superoxide dismutase activity, compared with normal cells [40]; (3) a significant decrease of superoxide dismutase activity is evident in the haemolysate of patients with rheumatoid arthritis [41]; (4) plasma levels of malondialdehyde, one of the products of free radical-induced lipid peroxidation, are significantly increased and correlated with the severity of disease activity in rheumatic patients [42]; (5) free radical products are generated in inflamed synovial fluids, and in those fluids ceruloplasmin may exert a protective role by inhibiting iron catalyzed peroxidation reactions [28].…”

Section: (D) a Possible Mechanism Of Actionmentioning

confidence: 99%

“…However, evidence coming particularly from studies on superoxide anion production and superoxide dismutase activity in rheumatic patients [40,41], together with the results obtained in acutely-inflamed copper-deficient rats [14, 49,53,54], led to the suggestion that any condition responsible for an enhanced production of free radicals in vivo could significantly exacerbate, if not prime, the inflammatory reaction [34]. Thus, as noted earlier for chronic inflammation, the requirement for copper in free radical metabolism may have a predominant, although not exclusive, role in explaining the activity of this metal as an acute anti-inflammatory agent.…”

Section: (D) a Possible Mechanism Of Actionmentioning

confidence: 99%

Review: Copper and inflammation — a possible rationale for the pharmalogical manipulation of inflammatory discorders

et al. 1985

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Acute and chronic inflammations are characterized, among other features, by changes in the metabolism of copper and by a widespread responsiveness to the therapy with copper-containing molecules. The exact map of inflammation-induced copper movements as well as the role played by the metal in the pathogenesis of inflammatory disorders are, however, far from being clear, and this is especially true in the case of chronic processes. Nevertheless the present knowledge suggests that the "copper approach' may provide a new way for coping with the problem of anti-inflammatory/anti-arthritic therapies. The administration of exogenous copper, and the in vivo manipulation of the endogenous metal levels are proposed as two possible therapeutic strategies, not necessarily mutually exclusive. For a better understanding of the value of such an approach, further research work is needed, especially to attain a more detailed know-how on the involved chemical forms, distribution and functions of copper in both normal as well as inflamed organisms.

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Serum copper and erythrocyte superoxide dismutase in rheumatoid arthritis.

Cited by 60 publications

References 23 publications

Relationship of Cellular Oxidant and Antioxidant Status with Disease Activity in Patients with Rheumatoid Arthritis

Relationship of Cellular Oxidant and Antioxidant Status with Disease Activity in Patients with Rheumatoid Arthritis

Status of oxidants and antioxidants in rheumatoid arthritis patients of north Karnataka

Review: Copper and inflammation — a possible rationale for the pharmalogical manipulation of inflammatory discorders

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