Serum Conjugated Bilirubin in Newborns of Mothers Treated With Immunosuppressive Drugs

Effects of immunosuppressive drugs during pregnancy

“…One study reported that the use of 6-mercaptopurine, given in combination with other chemotherapeutic agents at 24 weeks' gestation, for treatment of acute myelogenous leukemia, resulted in an offspring born prematurely at 34 weeks' gestation; the infant, although small for gestational age, had no hematopoietic problems or structural abnormalities (62). Sixmercaptopurine has also been used in the treatment of erythroblastosis fetalis without side effects (63). In 3 patients with inflammatory bowel disease, 2 women were treated until the third and fourth weeks of gestation, respectively, and 1 man was taking this drug at the time of conception.…”