What's good for the goose should be good for the gander-6-MP use in fathers with inflammatory bowel disease

Inflammatory Bowel Disease and Pregnancy

“…Most of the concern surrounding the use of AZA/6‐MP has focused on the pregnant woman; however, recently concerns have been raised regarding the risk of pregnancy related complications when the father is or has taken 6‐MP (77,78). In a retrospective review of pregnancy outcome among fathers treated with 6‐MP compared with fathers who had never been treated with 6‐MP, the incidence of pregnancy‐related complications was significantly increased when fathers used 6‐MP within 3 months of conception (78).…”

Understanding the Cautions and Contraindications of Immunomodulator and Biologic Therapies for Use in Inflammatory Bowel Disease

“…Although this study was congruent with older animal studies and a Danish human study that suggested a similar trend, 39 this study was fiercely criticized for its low statistical power and wide confidence intervals. 40 More importantly, more recent studies failed to duplicate these concerning findings, 41–43 and recent ECCO guidelines on reproduction and pregnancy do not recommend the peri-conception discontinuation of thiopurines. 44 …”

Approach to Gastrointestinal and Liver Diseases in Pregnancy

“…Secondly, there were relatively few retrospective studies on the safety of immunomodulators in the pregnant patient with IBD, most of which reported an increased risk for congenital malformations [101]. Most studies were limited by the retrospective nature of the data collection, the small sample size, and the lack of information regarding disease activity in the fathers and comorbidity in the mothers [105]. Most studies were limited by the retrospective nature of the data collection, the small sample size, and the lack of information regarding disease activity in the fathers and comorbidity in the mothers [105].…”