Serum concentrations of zinc and selenium in elderly people: results in healthy nonagenarians/centenarians

Savarino, L.; Granchi, Donatella; Ciapetti, G.; Cenni, E.; Ravaglia, Giovanni; Forti, Paola; Maioli, Fabiola; Mattioli, Roberto

doi:10.1016/s0531-5565(00)00218-7

Cited by 120 publications

(71 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, we have investigated oxidative stress in groups relatively close in age (55-70 vs 70-85 y) and generally in healthy condition. In healthy older subjects, like nonagenarian and centenarian, other studies also reported a biological antioxidant status similar to those of younger elderly subjects (Hininger et al, 1997;Savarino et al, 2001). Interestingly, we have found a significant positive correlation between iron status and TBARS, and we confirm in our population the relation described by others (Lasheras et al, 2003;HiningerFavier et al, 2004).…”

Section: Discussionsupporting

confidence: 91%

“…We also found a negative linear regression between age and TBARS levels (r ¼ À0.20; P ¼ 0.01), whereas others have reported a positive correlation between age and TBARS levels (Junqueira et al, 2004). In agreement with the present findings, some studies did not report a modified production of lipoperoxides with advancing age (Hininger et al, 1997;Savarino et al, 2001). The impact of age at enrolment in these different studies and those of lifestyle factors might explain the discrepancies between the studies.…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study

et al. 2005

View full text Add to dashboard Cite

Objective: Oxidative stress has been reported to increase with ageing. However, the data in healthy humans remain controversial and studies in free-living elderly people are scarce. The objective of the present study was to compare age-related oxidative stress in late middle-aged and older free-living subjects. Design: The effect of ageing on oxidative stress and antioxidant parameters was investigated in 188 middle-aged subjects from Clermont-Ferrand (France) and Coleraine (UK), and in 199 older subjects from Grenoble (France) and Roma (Italy). Plasma thiol (SH) groups, define definition (TBAR's) and total glutathione (GSH), define definition (FRAP), and superoxide dismutase (SOD) activity were measured at baseline of the ZENITH study. Results: Plasma SH groups and FRAP and, surprisingly, TBAR's were significantly lower in free-living older subjects compared to younger subjects (Po0.001, Po0.001, Po0.01, respectively), but there was no significant differences in GSH levels. Conclusion: European free-living healthy older do not appear to be exposed to an acute oxidative stress. However, the highly significant positive correlation between plasma SH group oxidation or decreased FRAP and ageing is predictive of an increased risk of oxidative stress in older subjects. Moreover, the comparison between middle-aged and older subjects regarding oxidative stress parameters suggests also a progressive and slow decline of antioxidant status in healthy free-living older elderly and underline the impact on life-style factors on successful ageing.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 87%

Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study

et al. 2005

View full text Add to dashboard Cite

show abstract

“…This result is noteworthy because only a small number of individuals had baseline selenium concentrations below the cutoff of 0.75 mol/L, which has been defined by a group of European experts (27 ) as a value related to selenium subdeficiency; however, as stated previously, many individuals have plasma selenium concentrations below the cutoff considered as optimal (2,3 ). These results are in agreement with the low percentages of selenium deficiencies reported as a possible explanation for longevity in the nonagenarian-centenarian study (28 ). On the other hand, Wei et al (6 ) found no association between total death and baseline selenium status in a cohort with a mean serum concentration of 0.93 mol/L in younger individuals (mean age, 57 years).…”

Section: Discussionsupporting

confidence: 87%

Selenium and Mortality in the Elderly: Results from the EVA Study

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Favorable climate provides abundant natural resources and suitable environment, which is beneficial for living healthier and longer. Former studies revealed that rich Selenium and Zinc in both natural environment and centenarians' body were largely found in China's "longevity villages", indicating those trace elements could influence the geographical aggregation distribution of the longevity, particularly for the centenarian proportion (Liu et al, 2013;Magnolfi et al, 2009;Savarino et al, 2000). Economic factors are also associated with longevity, through adequate food, balanced nutrition, good education, social security, and good access to healthcare, in addition to general satisfaction and happiness (Brown et al, 2012;Yi, D. Gu, & Land, 2007).…”

Section: Discussionmentioning

confidence: 99%

Regional aging and longevity characteristics in China

Wang

et al. 2016

Archives of Gerontology and Geriatrics

View full text Add to dashboard Cite

The factors that influence the length of human life are complex and longevity remains a controversial topic, particularly in China. This paper demonstrates the spatial patterns and changes of the elderly group (65 years old and over), the oldest old (80 years old and over) and the centenarians in China in the last decade, analyzes the influence of economic development on aging, and in the end, using a case study, explores the characteristics of the centenarians' behavior. The results indicate that high elderly and the oldest old proportions are more common in regions with higher socio-economic development and that have a favorable climate. Centenarian distribution pattern is less influenced by economic but only for few regions. Lifestyle factors, such as sufficient sleep, positive mental state and a light diet are also largely found among the centenarian group.

show abstract

Serum concentrations of zinc and selenium in elderly people: results in healthy nonagenarians/centenarians

Cited by 120 publications

References 23 publications

Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study

Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study

Selenium and Mortality in the Elderly: Results from the EVA Study

Regional aging and longevity characteristics in China

Contact Info

Product

Resources

About