Serum concentrations of TNF-α and soluble TNF-α receptors in obesity

Abstract

OBJECTIVE: To study whether weight reducing treatment modulates serum concentration of TNF-a a and two soluble TNF-a a receptors in obese subjects. SUBJECTS AND MEASUREMENTS: Serum concentrations of TNF-a a and two soluble receptors (sTNF-R1, sTNF-R2), plasma glucose, insulin, total cholesterol, HDL-cholesterol and triglicerides were measured in 27 obese subjects (age 48 AE 12 y, body mass index (BMI): 36 AE 6 kgam 2 ) before and after 3 months weight reducing treatment consisted of a diet & 1000 kcaladay and physical exercises. RESULTS: The mean loss of weight during 3 months' treatment was 9.3 AE 3.3 kg. The serum concentration of TNF-a a decreased after weight loss and at the same time both of the receptors (sTNF-R1,sTNF-R2) increased signi®cantly. CONCLUSION: The observed decrease of the serum concentration of TNF-a a and the increase in both TNF soluble receptors after weight reducing treatment in obese subjects, may be a counter-regulation preventing further weight loss.

High intensity interval training favourably affects antioxidant and inflammation mRNA expression in early-stage chronic kidney disease

“…This is noteworthy as decreased TNFRSF1B protein expression has been linked to increases in TNFα-induced apoptosis in cells that are crucial to immuno-regulation and inflammatory responses such as lymphocytes [32]. Considering our findings, in conjunction with findings that describe (a) the ability of chronic aerobic exercise to significantly reduce TNFα mRNA expression [33], (b) the inverse relationship between serum levels of TNFα and TNF receptors [34], and (c) the inverse relationship between TNFα-induced apoptosis and TNFRSF1B protein expression [32], we propose that HIIT favourably influences TNFα activity, as evidenced by an increase in the expression of Tnfrsf1b mRNA. Furthermore, based on our data, we propose the ability of exercise to influence TNFα activity is intensity-dependant as HIIT resulted in a significant up-regulation of Tnfrsf1b mRNA expression, compared to LIT (p=0.047).…”

Gluteofemoral body fat as a determinant of metabolic health

“…103 TNF-a is a strong inducer of lipolysis 104 and data from rodents and humans support a role in the development of insulin resistance. [105][106][107] The latter, however, has been challenged by others 108 and although TNF-a levels are increased in obesity, 109,110 there is little direct release from abdominal subcutaneous adipose tissue in vivo. 111 Interestingly, in a similar set of studies it was found that abdominal subcutaneous adipose tissue releases the soluble TNF receptor type 1 and that its levels correlate with BMI.…”

Biological role of tumor necrosis factor type α in physiology and pathophysiology

“…Nie zostało do końca wyjaśnione, czy za PCOS odpowiada jeden czynnik, czy też może kilka, interesujący jest również wpływ na rozwój PCOS diety i otyłości. W badaniach, w których dokonano oceny polimorfizmu genu TNF-α i jego receptora -TNFR2, nie wykazano istotnych korelacji między polimorfizmem regionu 308 genu TNF-α a występowaniem PCOS [17]. U kobiet z otyłością, ale też i szczupłych z PCOS, stwierdzono zwiększone stężenie TNF-α w surowicy, które korelowało dodatnio z masą ciała, a ujemnie z wrażli-wością na insulinę.…”

“…Dotychczas TNF-α postrzegany był jako czynnik stanów patologicznych, takich jak: wstrząs septyczny, nowotwory czy też zakażenia. Zupełnie nową informacją było stwierdzenie ekspresji TNF-α mRNA w adipocytach u otyłych ludzi i zwierząt [17]. Część badań naukowych potwierdziła zwiększoną ekspresję receptorów dla TNF-α w tkance tłuszczowej, a także zwiększone stężenie rozpuszczalnych form receptorów dla TNF-α w surowicy.…”