Serum concentrations of pesticides including organophosphates, pyrethroids and neonicotinoids in a population with osteoarthritis in Saudi Arabia

Li, Adela Jing; Banjabi, Abeer A.; Takazawa, Mari; Kumosani, Taha; Yousef, Jehad M.; Kannan, Kurunthachalam

doi:10.1016/j.scitotenv.2020.139706

Cited by 47 publications

(24 citation statements)

References 36 publications

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“…These ndings indicated that human exposure to NEOs and their metabolites was associated with liver cancer, and the blood levels of NEOs and their metabolites were correlated with increased odds of liver cancer prevalence in this population from China. Our results were similar to recent reports, which showed that human exposure to NEOs and their metabolites would increase the odds of disease prevalence (i.e., osteoporosis and periodontitis) (Li et al 2020a…”

Section: Association Of Blood Levels Of Neos and Their Metabolites With Liver Cancersupporting

confidence: 92%

“…Moreover, the median levels of most NEOs and their metabolites (except for IMI and UF) in blood samples collected from the healthy population were considerably higher than those reported by Xu et al (2021) (Table2). With the comparison of previous studies reported on serum samples, the median blood concentrations of ACE (0.49 and 0.29 ng/mL), THI (0.21 and 0.29 ng/mL), and THIX (0.20 and 0.19 ng/mL) in this study are relatively higher than those reported in South China (ACE: 0.04 and 0.05 ng/mL; THI: 0.06 and 0.01 ng/mL; THIX: 0.16 and 0.16 ng/mL) (Zhang et al, 2021), East China (ACE: < 0.005 ng/mL; THI: < 0.018 ng/mL; THIX: < 0.023 ng/mL) (Chen et al 2021), and Saudi Arabia (ACE: < 0.002 ng/mL; THI: not detected; THIX: < 0.061 ng/mL; Table2)(Li et al 2020a). However, the median blood levels of UF (1.88 and 0.73 ng/mL) and Of-IMI (2.03 and 1.28 ng/mL) were comparable to those reported in South China (UF: 1.27 and 0.73 ng/mL; Of-IMI: 3.08 and 1.41 ng/mL), but the median concentration of ACE-dm (1.61 and 0.79 ng/mL) was signi cantly lower (5.99 and 2.02 ng/mL; Table2)(Zhang et al 2021c).…”

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confidence: 99%

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Concentrations of Neonicotinoids and their Characteristic Metabolites in Blood Samples from South China: Association with Liver Cancer

Zhang¹,

Zhang²,

Zeng³

et al. 2021

Preprint

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Neonicotinoid insecticides (NEOs) are commonly applied for pest control in China and around the world. They have potential toxicity to bees, birds, mammals, and even human being. However, limited studies have explored the associations between NEOs exposure and disease. In the present study, we detected six parent NEOs (p-NEOs), including acetamiprid, thiacloprid, dinotefuran, clothianidin, imidacloprid, and thiamethoxam, and five characteristic metabolites (m-NEOs), including 5-hydroxy-imidacloprid (5-OH-IMI), olefin-imidacloprid (Of-IMI), N-desmethyl-acetamiprid, 1-methyl-3-(tetrahydro-3-furylmethyl) guanidine and 1-methyl-3-(tetrahydro-3-furyl methyl) urea, in blood samples collected from healthy (n = 100) and liver cancer (n = 274) populations in South China. NEOs were frequently detected (61–94%) in blood samples, with median concentrations ranging from 0.19 ng/mL to 1.28 ng/mL and 0.20 ng/mL to 2.03 ng/mL for healthy and liver cancer populations, respectively. Of-IMI was the most abundant NEOs in healthy and liver cancer populations, accounting for 23.4% and 20.7%, respectively. Significant positive correlations among most m-NEOs concentrations were found, and associations between m-NEOs and their corresponding p-NEOs were positively correlated. These findings indicated that the sources of m-NEOs were both endogenous and exogeneous. Females had higher median concentrations of NEOs and their metabolites than males. Moreover, associations between the concentrations of p-NEOs and m-NEOs and liver cancer were found (odds ratio = 2.33–9.02, 95% confidence interval = 0.31–22.7, p < 0.05), indicating that human exposure to NEOs and their metabolites might increase the odds of liver cancer prevalence. This study is the first work to document 5-OH-IMI and DN in blood samples collected from South China.

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Section: Association Of Blood Levels Of Neos and Their Metabolites With Liver Cancersupporting

confidence: 92%

mentioning

confidence: 99%

Concentrations of Neonicotinoids and their Characteristic Metabolites in Blood Samples from South China: Association with Liver Cancer

Zhang¹,

Zhang²,

Zeng³

et al. 2021

Preprint

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“…The enzyme kinetics tests in RLM and CLM were performed with four fosthiazate optical stereoisomers. As described in Section 2.2, a series of concentrations (2,4,8,16,32, and 64 μM) of each fosthiazate stereoisomer were added to the RLM and CLM incubation systems. Then, the RLM and CLM incubation systems were incubated for 8 and 15 min to obtain the kinetic parameters, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…The Food and Agriculture Organization (FAO) of the United Nations reported that the usage amount of pesticides continued to increase with the steady growth of global food production from 1949 to 2014 . Pesticides enter organisms though environmental exposure and food residues. − Previous studies indicated that pesticides may cause a range of adverse effects on organisms. − Therefore, it is of great significance to elucidate the clearance and metabolism characteristics of pesticides in organisms.…”

Section: Introductionmentioning

confidence: 99%

Intrinsic Clearance and Metabolism Pathway of Fosthiazate in Rat and Cock Liver Microsomes: From Chiral Assessment View

Shi

Hua

et al. 2021

J. Agric. Food Chem.

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Chiral fosthiazate enters the organisms via environmental exposure and food web enrichment. Liver subcellular fractions of rats (RLM) and cocks (CLM) were prepared to explore the stereoselective metabolism of fosthiazate in vitro. The results indicated that fosthiazate exhibited different stereoselective metabolism behaviors in RLM and CLM. The clearance rate order of RLM to four fosthiazate stereoisomers was (1R,3R)-fosthiazate > (1S,3R)-fosthiazate > (1R,3S)-fosthiazate > (1S,3S)-fosthiazate. However, CLM showed a faster clearance rate to (1S,3S)-fosthiazate and (1S,3R)-fosthiazate than the other two stereoisomers. The molecular docking results revealed that the stereoselectivity was partially due to the stereospecific binding between fosthiazate stereoisomers and cytochrome P450 proteins. The main metabolism pathways of fosthiazate in RLM and CLM were oxidation and hydrolysis with five common metabolites including M299, M243, M227, M103, and M197 being identified by LC-TOF-MS/MS. The present study provides the accurate data on risk assessment of chiral fosthiazate.

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“…Neonicotinoids have been reported to reduce the reproduction of bees and increase their mortality via inhibiting their homing ability (Rundlof et al 2015, Stanley et al 2015, Woodcock et al 2017. A previous study showed that serum concentrations of IMI and ACE are 0.65 and 0.06 µg/L, respectively, in people over sixty years old in Saudi Arabia (Li et al 2020 Chlorpyrifos (CRF) is a typical organophosphorus pesticide and neurotoxic insecticide, as an acetylcholinesterase inhibitor that overstimulates the nervous system. It is extensively applied to seeds, lawns, and crops.…”

Section: Introductionmentioning

confidence: 99%

Combined Toxicity of Chlorpyrifos, Abamectin, Imidacloprid, And Acetamiprid On Earthworms (Eisenia Fetida)

Teng

Zhao

Wang

et al. 2021

Preprint

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Mixed pesticides have been broadly used in agriculture. However, assessing the combined effects of pesticides in the environment is essential for potential risk assessment, though the task is far from complete. Median lethal concentrations of pesticides as well as acetylcholinesterase (AChE) levels and cellulose activities were measured in earthworms (Eisenia fetida) individually and jointly exposed to pesticides imidacloprid (IMI), acetamiprid (ACE), chlorpyrifos (CRF), and abamectin (ABM)). A 3:1 mixture of CRF and IMI had additive effects, while a 3:1 mixture of CRF and ACE had synergic effects. The joint effects of ABM with IMI or with ACE were synergistic. As CRF concentration increased, AChE activities were significantly decreased. For high concentrations of IMI, AChE activities under combined CRF and IMI applications were significantly inhibited following increased exposure time. Moreover, the cellulase activities under combined applications of CRF with IMI or with ACE had similar effects. This study provides basic data for scientifically evaluating the environmental risk and safety of combined uses of pesticides.

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Serum concentrations of pesticides including organophosphates, pyrethroids and neonicotinoids in a population with osteoarthritis in Saudi Arabia

Cited by 47 publications

References 36 publications

Concentrations of Neonicotinoids and their Characteristic Metabolites in Blood Samples from South China: Association with Liver Cancer

Concentrations of Neonicotinoids and their Characteristic Metabolites in Blood Samples from South China: Association with Liver Cancer

Intrinsic Clearance and Metabolism Pathway of Fosthiazate in Rat and Cock Liver Microsomes: From Chiral Assessment View

Combined Toxicity of Chlorpyrifos, Abamectin, Imidacloprid, And Acetamiprid On Earthworms (Eisenia Fetida)

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