Serum concentrations of per-/polyfluoroalkyl substances and its association with renal function parameters among teenagers near a Chinese fluorochemical industrial plant: A cross-sectional study

Xie, Lin-Na; Wang, Xiaochen; Su, Liqin; Ji, Saisai; Dong, Xiao-Jie; Zhu, Huijuan; Hou, Sha-Sha; Wang, Cong; Li, Zhenhuan; Dong, Bi Rong; Zhu, Ying

doi:10.1016/j.envpol.2022.119020

Cited by 18 publications

(5 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Per-and Polyfluoroalkyl substances are ubiquitous, man-made chemicals with a wide range of applications in industrial, household, and consumer products. They are used in the production of lubricants, paints, food packaging, fire-extinguishing foams, non-stick cookware coatings, and more [14][15][16].…”

Section: Per-and Polyfluoroalkyl Substances (Pfass)mentioning

confidence: 99%

Association of Combined Per- and Polyfluoroalkyl Substances and Metals with Chronic Kidney Disease

Haruna,

Obeng-Gyasi

2024

IJERPH

View full text Add to dashboard Cite

Background: Exposure to environmental pollutants such as metals and Per- and Polyfluoroalkyl Substances (PFAS) has become common and increasingly associated with a decrease in the estimated Glomerular Filtration Rate (eGFR), which is a marker often used to measure chronic kidney disease (CKD). However, there are limited studies involving the use of both eGFR and the urine albumin creatinine ratio (uACR), which are more comprehensive markers to determine the presence of CKD and the complexity of pollutant exposures and response interactions, especially for combined metals and PFAS, which has not been comprehensively elucidated. Objective: This study aims to assess the individual and combined effects of perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), Cadmium (Cd), Mercury (Hg), and Lead (Pb) exposure on CKD using data from the National Health and Nutritional Examination Survey (NHANES) 2017–2018. Methods: We employed the use of bivariate logistic regression and Bayesian Kernel Machine Regression (BKMR) in our analysis of the data. Results: Logistic regression results revealed a positive association between PFOA and CKD. Our BKMR analysis revealed a non-linear and bi-phasic relationship between the metal exposures and CKD. In our univariate exposure–response function plot, Cd and Hg exhibited a U and N-shaped interaction, which indicated a non-linear and non-additive relationship with both low and high exposures associated with CKD. In addition, the bivariate exposure–response function between two exposures in a mixture revealed that Cd had a U-shaped relationship with CKD at different quantiles of Pb, Hg, PFOA, and PFOS, indicating that both low and high levels of Cd is associated with CKD, implying a non-linear and complex biological interaction. Hg’s interaction plot demonstrated a N-shaped association across all quantiles of Cd, with the 75th quantile of Pb and the 50th and 75th quantiles of PFOA and PFOS. Furthermore, the PIP results underscored Cd’s consistent association with CKD (PIP = 1.000) followed by Hg’s (PIP = 0.9984), then PFOA and PFOS with a closely related PIP of 0.7880 and 0.7604, respectively, and finally Pb (PIP = 0.6940), contributing the least among the five environmental pollutants on CKD, though significant. Conclusions: Our findings revealed that exposure to environmental pollutants, particularly Hg and Cd, are associated with CKD. These findings highlight the need for public health interventions and strategies to mitigate the cumulative effect of PFAS and metal exposure and elucidate the significance of utilizing advanced statistical methods and tools to understand the impact of environmental pollutants on human health. Further research is needed to understand the mechanistic pathways of PFAS and metal-induced kidney injury and CKD, and longitudinal studies are required to ascertain the long-term impact of these environmental exposures.

show abstract

Section: Per-and Polyfluoroalkyl Substances (Pfass)mentioning

confidence: 99%

Association of Combined Per- and Polyfluoroalkyl Substances and Metals with Chronic Kidney Disease

Haruna,

Obeng-Gyasi

2024

IJERPH

View full text Add to dashboard Cite

show abstract

“…Three cross-sectional studies found a positive correlation between CKD and measured PFOA ( Watkins et al, 2013 ). Whether children younger than 18 years old under the high exposure background in the United States ( n = 9,660) ( Xie et al, 2022 ), or adolescents under the high exposure background in China ( n = 1,612) ( Shankar et al, 2011b ), or the general population under the relatively low exposure background level in the United States ( n = 5,717), the serum PFOA level is positively related to chronic kidney disease. However, another cross-sectional study of adults in Shenyang, China found that most PFAS was positively correlated with CKD, except for PFOA and PFDA (perfluorodecanoic acid) ( Wang et al, 2019 ).…”

Section: The Relationship Between Perfluorooctanoic Acid (Pfoa) and K...mentioning

confidence: 99%

Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: A review of current available literature

et al. 2023

View full text Add to dashboard Cite

Perfluorooctanoic acid is an artificial and non-degradable chemical. It is widely used due to its stable nature. It can enter the human body through food, drinking water, inhalation of household dust and contact with products containing perfluorooctanoic acid. It accumulates in the human body, causing potential harmful effects on human health. Based on the biodegradability and bioaccumulation of perfluorooctanoic acid in the human body, there are increasing concerns about the adverse effects of perfluorooctanoic acid exposure on kidneys. Research shows that kidney is the main accumulation organ of Perfluorooctanoic acid, and Perfluorooctanoic acid can cause nephrotoxicity and produce adverse effects on kidney function, but the exact mechanism is still unknown. In this review, we summarize the relationship between Perfluorooctanoic acid exposure and kidney health, evaluate risks more clearly, and provide a theoretical basis for subsequent research.

show abstract

“…However, they and the PFAS that replaced them continue to be found in surface and groundwater sources. These legacy PFAS have been associated directly with increased risk of CKD in some (54)(55)(56)(57), but not all (58)(59)(60), studies, and inversely with GFR in several studies (56,61,62). The exact nature of the association of PFAS and CKD is ambiguous because serum concentrations of PFAS may increase with decreased kidney function (63).…”

Section: Watermentioning

confidence: 99%

Environmental Exposures and Kidney Disease

et al. 2022

View full text Add to dashboard Cite

Accumulating evidence underscores the large role played by the environment in the health of communities and individuals. We review the currently known contribution of environmental exposures and pollutants on kidney disease and its associated morbidity. We review air pollutants, such as particulate matter; water pollutants such as trace elements, per- and polyfluorooakyl substances, and pesticides; and extreme weather events and natural disasters. We also discuss gaps in the evidence which at present relies heavily on observational studies and animal models, and propose using recently developed quantitative methods to help bridge the gaps. With the expected increase in the intensity and frequency of many environmental exposures in the decades to come, an improved understanding of their potential effect on kidney disease is crucial to mitigate potential morbidity and mortality.

show abstract

Serum concentrations of per-/polyfluoroalkyl substances and its association with renal function parameters among teenagers near a Chinese fluorochemical industrial plant: A cross-sectional study

Cited by 18 publications

References 46 publications

Association of Combined Per- and Polyfluoroalkyl Substances and Metals with Chronic Kidney Disease

Association of Combined Per- and Polyfluoroalkyl Substances and Metals with Chronic Kidney Disease

Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: A review of current available literature

Environmental Exposures and Kidney Disease

Contact Info

Product

Resources

About