Environmental Exposures and Kidney Disease

Kshirsagar, Abhijit V.; Zeitler, Evan; Weaver, Anne M.; Franceschini, Nora; Engel, Lawrence S.

doi:10.34067/kid.0007962021

Cited by 12 publications

(7 citation statements)

References 90 publications

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“…Another study found that glyphosate use and the intensity of exposure were related to serum creatinine, but not to eGFR [ 50 ]. Some pesticides used by farmers in this study, such as alachlor, atrazine, glyphosate, paraquat, and permethrin, have been linked to CKD [ 51 ]. According to our findings, long-term pesticide exposure may cause nephrotoxic changes and increase the risk of CKD in vegetable farmers.…”

Section: Discussionmentioning

confidence: 99%

The Hematological and Biochemical Effects from Pesticide Exposure on Thai Vegetable Farmers

Bunsri,

Muenchamnan,

Naksen

et al. 2023

Toxics

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Pesticide-related health concerns are a global public health issue. Few studies in Thailand have explored the hematological and biochemical effects of occupational pesticide exposure. The goal of this study was to investigate the effects of pesticides on the hematology, hepatic, and renal function of Thai vegetable farmers. A cross-sectional study was carried out in Chiang Mai, northern Thailand. A total of 124 apparently healthy vegetable farmers were interviewed about their lifetime exposure to agricultural pesticides. Blood samples were collected via venipuncture to be tested for complete blood count (CBC), liver function, and kidney function. Approximately 46% of the farmers were pesticide users who reported a history of pesticide use for their crops, while 54% were non-pesticide users. In the male farmers, the activities of aspartate aminotransferase (AST), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were significantly higher in the pesticide users compared to the non-pesticide users, while the estimated glomerular filtration rate (eGFR), hematocrit (HCT), and red blood cells (RBC) were significantly lower (p < 0.05). In the females, the pesticide users had significantly higher levels of alanine aminotransferase (ALT), alkaline phosphatase (ALP), and MCHC than the non-pesticide users (p < 0.05). Pesticide use among Thai vegetable farmers may cause hematological alterations and increase the risk of hepatic and renal dysfunction. Some hematological and biochemical parameters may be used for monitoring to protect them from the adverse health effects of occupational exposure to pesticides.

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Section: Discussionmentioning

confidence: 99%

The Hematological and Biochemical Effects from Pesticide Exposure on Thai Vegetable Farmers

Bunsri,

Muenchamnan,

Naksen

et al. 2023

Toxics

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“…Air pollution contributes to over 4 million deaths annually [34 & ]. The association of air pollution, especially PM 2.5 , is with kidney dysfunction as reviewed elsewhere [33,47]. Literature on the impact of PM 2.5 on kidney development is scarce, however PM 2.5 and ozone exposure are associated with an up to 20% increased risk of LBW, a programming impact on fetal kidney development must be considered [34 & ].…”

Section: Air Pollutionmentioning

confidence: 99%

“…The consequences of wildfire smoke exposure extend beyond the respiratory system [ 6 ]. Particulate matter (PM) reflects the organic and inorganic particles in solid and liquid form suspended in the air [ 33 ]. PM is classified by particle size.…”

Section: Wildfiresmentioning

confidence: 99%

Climate change and its influence in nephron mass

Alvarez-Elias,

Brenner,

Luyckx

2023

Current Opinion in Nephrology &Amp; Hypertension

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Purpose The consequences of climate change, including heat and extreme weather events impact kidney function in adults and children. The impacts of climate change on kidney development during gestation and thereby on kidney function later in life have been poorly described. Clinical evidence is summarized to highlight possible associations between climate change and nephron mass. Recent findings Pregnant women are vulnerable to the effects of climate change, being less able to thermoregulate, more sensitive to the effects of dehydration, and more susceptible to infections. Exposure to heat, wildfire smoke, drought, floods and climate-related infections are associated with low birth weight, preterm birth and preeclampsia. These factors are associated with reduced nephron numbers, kidney dysfunction and higher blood pressures in offspring in later life. Exposure to air pollution is associated with higher blood pressures in children and has variable effects on estimated glomerular filtration rate. Summary Climate change has important impacts on pregnant women and their unborn children. Being born too small or too soon is associated with life-time risk of kidney disease. Climate change may therefore have a dual effect of impacting fetal kidney development and contributing to cumulative postnatal kidney injury. The impact on population kidney health of future generations may be significant.

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“…Renal failure development was also correlated with blood-Pb levels [56] a slower decline in renal function following lead chelation therapy [57]. Some publications claim that Cd and Pb may be responsible for the overall progression of renal disease [58]. The results showed that there is no significant increase in the tests compared to the control.…”

Section: Heavy Metals In Serum Blood Ckdmentioning

confidence: 99%

Investigation of some Heavy Metals on Parameter of Blood and Oxidative Enzyme in CKD in Iraq-Al-Qadisiyah

Aljashamy,

Hussein

2023

IOP Conf. Ser.: Earth Environ. Sci.

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Sampling Blood collected for patients with renal failure of the dialysis group and the non-dialysis group for randomly for (40-60) age. And conduct tests CBC. The oxidation enzymes and some of the sample heavy metal (Ai, Cd, Cr, Pb and As) after digestion and measured in atomic spectrophotometer the result show They found a clear relationship between kidney failure and the effect of heavy metals. Where it affected the blood rate and the number of white blood cells and oxidation enzymes. Where were the values after conducting the tests (12.8 ± 0.45) (9.57 ± 0.62) (9.43 ± 0.47) respectively for control, hemodialysis and non-hemodialysis for Hp. Tests for WBCs (7.8 ± 0.32) (8.07 ± 0.75) (8.37 ± 0.50) respectively for control, hemodialysis and non-hemodialysis. The results of the current study showed in the age group (40_60) that there was a decrease in significant at (P< 0.05) in SOD, GSH and CAT for hemodialysis patients compared with control (0.336±0.035 Mg\dl), (0.4086±0.0041 Mg\dl) and (0.191±0.0051 Mg\dl) Consecutively, according to the table indicated (1-2) and That’s agreement with previous studies. The results of the current study showed in the age group (40_60) that there was a decrease in significant at (P< 0.05) in SOD, GSH and CAT for non-hemodialysis patients compared with control (0.748±0.071 Mg\dl), (0.838±0.019Mg\dl) and (0.335±0.0023 Mg\dl) Consecutively, according to the table indicated (1-2) and That’s agreement with previous studies

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Environmental Exposures and Kidney Disease

Cited by 12 publications

References 90 publications

The Hematological and Biochemical Effects from Pesticide Exposure on Thai Vegetable Farmers

The Hematological and Biochemical Effects from Pesticide Exposure on Thai Vegetable Farmers

Climate change and its influence in nephron mass

Investigation of some Heavy Metals on Parameter of Blood and Oxidative Enzyme in CKD in Iraq-Al-Qadisiyah

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