Serum concentrations of nitric oxide, tumor necrosis factor (TNF)-α and TNF soluble receptors in women with overweight and obesity

Olszanecka-Glinianowicz, Magdalena; Zahorska-Markiewicz, Barbara; Janowska, Joanna; Żurakowski, Aleksander

doi:10.1016/j.metabol.2004.07.001

Cited by 104 publications

(81 citation statements)

References 19 publications

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“…The relation of CRP to abdominal adiposity has been reported to be due to the production of cytokines in adipose tissue, tumor necrosis factor (TNF)-α ,and interleukin (IL)-6. Indeed, the serum concentrations of TNF-α [47][48][49][50] and soluble serum TNFreceptor-2 [49] are higher in obesity; and TNF-α induces hepatic CRP production [51]. Likewise, IL-6 also induces hepatic production of CRP [52]; and serum IL-6 concentrations are higher in obesity [50].…”

Section: Discussionmentioning

confidence: 99%

Fat redistribution preferentially reflects the anti-inflammatory benefits of pioglitazone treatment

Moon

Kim

et al. 2011

Metabolism

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Section: Discussionmentioning

confidence: 99%

Fat redistribution preferentially reflects the anti-inflammatory benefits of pioglitazone treatment

Moon

Kim

et al. 2011

Metabolism

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“…29,34,[45][46][47][48][49][50][51][52][53][54][55] Female data were compiled from 15 studies (26 groups of individuals), with study sample size ranging from 8 to 662 individuals and a mean sample size of 94. 29,45,46,48,50,[53][54][55][56][57][58][59][60][61][62] Lack of BMI-adiponectin association S-M Kuo and MM Halpern Among these studies, eight studies included subjects of both genders and the measurements from men and women were reported separately. The sample size as well as the age and BMI profiles of these studies are summarized in Table 1.…”

Section: Data Collectionmentioning

confidence: 99%

“…After applying our data exclusion criteria, we found very limited information available on the plasma TNFa level of healthy adult men (Figure 3a), 29,55 so regression analysis was not possible. The regression analysis of female TNFa to BMI was based on data from 12 groups (Figure 3b) 29,55,[57][58][59][60] and Pearson's correlation was 0.51 (P40.05, not significant). There was also limited information available (six groups) on the plasma IL-6 level of healthy adult men (Figure 4a).…”

Section: Analyses Of Tnfa and Il-6mentioning

confidence: 99%

Lack of association between body mass index and plasma adiponectin levels in healthy adults

Kuo

2011

Int J Obes

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Objectives: To test the hypothesis that obesity (increase in fat mass) independently affects the level of adipokines: adiponectin, tumor necrosis factor-a (TNFa) and interleukin (IL)-6. Methods: Publications in the past decade reporting adult plasma adiponectin, leptin, TNFa and/or IL-6 levels were compiled. Mean gender-specific values were extracted from studies that included medical screening to confirm physical health (43 groups, total 4852 subjects). Correlation analysis was conducted between adipokine levels and body mass index (BMI), a widely used estimate of adiposity. Results: For healthy lean to obese adults of both genders, no significant correlation between plasma adiponectin and BMI was detected. There was also no gender difference in plasma adiponectin level. In contrast, leptin levels showed a positive correlation with BMI in both genders, and women had significantly higher levels of plasma leptin consistent with a higher percentage of body fat. The proinflammatory cytokine TNFa failed to show correlation with BMI. Although IL-6 showed a positive correlation with BMI in women, the obesity-related increase was very limited. Conclusions: Data analysis based on studies performed on healthy adults did not support the hypothesis that obesity independently affects the plasma level of adiponectin and TNFa. Reported obesity-related changes in plasma adipokine levels may be a consequence of obesity-related metabolic disorders. Future studies are especially needed to understand the homeostasis of adiponectin.

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“…Magdalena Olszanecka-Glinianowicz 1 system activation [7,8], disturbance of neurotransmitter secretion [9][10][11][12][13] and immune activation [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Is the depression level the factor influencing the effectiveness of the group weight reduction program?

Olszanecka-Glinianowicz¹,

Kocełak²,

Gruszka³

et al. 2014

noms

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Introduction: The aim of the study was to assess the influence of the depression level on the effects of the group weight reduction program. Material and methods:The study group involved 57 overweight and obese subjects [age 45.9 ± 13.9 years, body mass index (BMI) 35.5 ± 5.4 kg/m 2 ]. All patients participated in a 3-month group weight reduction program. Body mass and height were measured and BMI was calculated, the depression level was assessed using Beck's Depression Inventory (BDI) at baseline and at the end. Results: At baseline, the moderate depression level occurred in 8 women (BDI 23.1 ± 3.0 points), mild depression level in 22 subjects -20 women and 2 men (BDI 13.4 ± 2.4 points) and 27 subjects -22 women and 5 men did not have features of depression (BDI 5.5 ± 2.8 points). Subjects with severe and mild depression levels were significantly older than these without features of depression (p < 0.005). We did not observe differences of BMI between study subgroups. There were no correlations between body mass and BMI, and the depression levels. The body mass and depression levels decreased significantly in all study subgroups after the group weight reduction program with psychotherapy. We observed a significant decrease in both body mass and depression level in all study subgroups. The mean weight reduction was similar in all study subgroups. Conclusion:The depression level at baseline did not influence the effectiveness of the group weight reduction program.

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Serum concentrations of nitric oxide, tumor necrosis factor (TNF)-α and TNF soluble receptors in women with overweight and obesity

Cited by 104 publications

References 19 publications

Fat redistribution preferentially reflects the anti-inflammatory benefits of pioglitazone treatment

Fat redistribution preferentially reflects the anti-inflammatory benefits of pioglitazone treatment

Lack of association between body mass index and plasma adiponectin levels in healthy adults

Is the depression level the factor influencing the effectiveness of the group weight reduction program?

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