Serum concentrations of human insulin-like growth factor-1 and levels of insulin-like growth factor-binding protein-5 in patients with nonalcoholic fatty liver disease

Abstract

Serum IGFBP-5 levels may be useful to differentiate both advanced fibrosis and definite nonalcoholic steatohepatitis from other NAFLD groups. Also, serum IGF-1 levels may be useful to differentiate advanced fibrosis in patients with NAFLD.

Lower levels of insulin‐like growth factor‐1 standard deviation score are associated with histological severity of non‐alcoholic fatty liver disease

“…We also found a negative relationship between IGF‐1 SDS and hepatic fibrosis. Our data are consistent with previous studies exploring the association of circulating IGF‐1 levels with hepatic fibrosis . The expression of IGF‐1 mRNA decreased with an increasing degree of fibrosis and serum IGF‐1 levels were well correlated with the NAFLD fibrosis score which is known to be a non‐invasive index for assessing the severity of hepatic fibrosis .…”

Development and Validation of Insulin-like Growth Factor-1 Score to Assess Hepatic Reserve in Hepatocellular Carcinoma

“…The highest category for IGF-1 (<26ng/mL = score 3) in our study is consistent with recent reports of the association between advanced cirrhosis (CTP class C) and IGF-1 levels of less than 25ng/mL (26) and less than 27ng/mL (27). Our middle IGF-1 score range (26–50ng/mL = score 2) is also supported by studies that found that mean circulating IGF-1 levels of 45ng/mL (27) and 57ng/mL (28) correlated with CTP class B and moderate histologic liver fibrosis in patients with cirrhosis, respectively. Furthermore, we did not observe statistically significant demographic or clinicopathologic differences between enrolled patients with or without available samples; therefore, there is no evidence of selection bias.…”

Emerging Liver–Kidney Interactions in Nonalcoholic Fatty Liver Disease

“…The effects of IGFs are modulated by their binding to six IGF binding proteins (IGFBPs), which provide a reservoir of IGFs and transport IGF to peripheral tissues, but may have also IGFindependent actions. IGF-1 derives largely from the liver, and in NAFLD patients IGF-1 levels are reduced, and are independently and inversely related to the severity of liver histology [90,91], suggesting that hepatic insulin resistance may inhibit GH-stimulated synthesis of IGF-1 (Table S2). …”