2003
DOI: 10.1097/00007691-200308000-00007
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Serum Concentrations and Effects of Gabapentin and Vigabatrin

Abstract: To explore possible concentration-effect relationships, gabapentin (GBP) and vigabatrin (VGB) serum concentrations were obtained from patients participating in an add-on dose-titration trial comparing GBP and VGB in partial epilepsy. Patients randomized to GBP started on 1800 mg/d and could have their dosage increased stepwise to 2400 and 3600 mg/d if seizures persisted. Those randomised to VGB started on 1000 mg/d, and the dose could be increased to 2000 and 4000 mg/d. Blood samples were obtained at steady st… Show more

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Cited by 43 publications
(29 citation statements)
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“…e Drug shows zero-order elimination kinetics. f References for reference ranges: felbamate [42,43], gabapentin [44], lacosamide [45], lamotrigine [46], levetiracetam [47], oxcarbazepine (10-hydroxycarbazepine metabolite) [48], pregabalin [2], stiripentol [49], tiagabine [50], topiramate [51], vigabatrin [23], zonisamide [52]. …”
Section: The Challenge Of Establishing Reference Ranges For Aedsmentioning
confidence: 99%
See 1 more Smart Citation
“…e Drug shows zero-order elimination kinetics. f References for reference ranges: felbamate [42,43], gabapentin [44], lacosamide [45], lamotrigine [46], levetiracetam [47], oxcarbazepine (10-hydroxycarbazepine metabolite) [48], pregabalin [2], stiripentol [49], tiagabine [50], topiramate [51], vigabatrin [23], zonisamide [52]. …”
Section: The Challenge Of Establishing Reference Ranges For Aedsmentioning
confidence: 99%
“…A wide range of serum/plasma concentrations are associated with clinical effect [66] although effective control of seizures typically requires concentrations above 2 mg/L [67]. An approximate reference range of 2–20 mg/L has been proposed [44]. Multiple analytical methodologies have been reported for the measurement of gabapentin in plasma/serum including HPLC [68,69], HPLC-tandem mass spectrometry (LC/MS/MS) [70], gas chromatography/mass spectrometry (GC/MS) [71] and GC/MS/MS [72].…”
Section: Gabapentinmentioning
confidence: 99%
“…The mean plasma concentration of gabapentin attained after a preoperative dose of 600 mg (31.9 ± 12.7 lmolÁL -1 ) compares with that found in previous studies. 12 These levels remained constant throughout and after the period of CPB. Cardiac surgery may affect drug pharmacokinetics in a number of ways, including substantial fluid shifts and specific effects attributable to the CPB circuit and oxygenator.…”
Section: Discussionmentioning
confidence: 87%
“…Table 1 summarizes the pharmacokinetic properties of the AEMs, while Table 2 presents a summary of the justifications of TDM for the AEMs. References for reference ranges used in Table 1 are as follows: carbamazepine, clonazepam, phenobarbital, phenytoin, primodone, valproic acid (Hardman et al, 1996), felbamate (Faught et al, 1993;Sachdeo et al, 1992), gabapentin (Lindberger et al, 2003), lacosamide (Kellinghaus, 2009), lamotrigine (Bartoli et al, 1997) (Friis et al, 1993), pregabalin (Patsalos et al, 2008), stiripentol (Farwell et al, 1993), tiagabine (Uthman et al, 1998), topiramate , vigabatrin (Patsalos, 1999), and zonisamide (Glauser & Pippenger, 2000;Mimaki, 1998).…”
Section: Reference Ranges For Aemsmentioning
confidence: 99%
“…The bulk of excretion is via the kidneys, with the halflife increasing in patients with renal failure. Hemodialysis effectively clears gabapentin (Hung et al, 2008;Wong et al, 1995 (Lindberger et al, 2003). TDM is not usually necessary for gabapentin therapy other than to adjust dosing in patients with impaired kidney function or to assess adherance to therapy (Patsalos et al, 2008) …”
Section: Gabapentinmentioning
confidence: 99%