Serum concentration of zinc is elevated in clinically stable bipolar disorder patients

Jonsson, B.; Orhan, Funda; Bruno, S.; Oliveira, Ana Osório; Sparding, Timea; Landén, Mikael; Sellgren, Carl M.

doi:10.1002/brb3.2472

Cited by 6 publications

(2 citation statements)

References 45 publications

(54 reference statements)

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“…Additionally, treatment with magnesium sulfate in patients with aneurysmal subarachnoid hemorrhage did not affect serum S100B levels [52] while in patients with eclampsia [53] and neonatal hypoxicischemic encephalopathy [54], this treatment lead to the decrease in CSF and serum S100B levels, respectively. Regarding the association of YKL-40 with metals, we found only one study in patients with bipolar disorder that showed no association between serum Zn and serum YKL-40 levels [55]. Regarding NFL, studies in experimental animals showed that As treatment leads to NFL disappearance [56], while Al treatment reduced NFL mRNA levels [57].…”

Section: Discussionmentioning

confidence: 87%

Heavy Metals and Essential Metals Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease

Leko

Mihelčić

Jurasović

et al. 2022

IJMS

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Various metals have been associated with the pathogenesis of Alzheimer’s disease (AD), principally heavy metals that are environmental pollutants (such as As, Cd, Hg, and Pb) and essential metals whose homeostasis is disturbed in AD (such as Cu, Fe, and Zn). Although there is evidence of the involvement of these metals in AD, further research is needed on their mechanisms of toxicity. To further assess the involvement of heavy and essential metals in AD pathogenesis, we compared cerebrospinal fluid (CSF) AD biomarkers to macro- and microelements measured in CSF and plasma. We tested if macro- and microelements’ concentrations (heavy metals (As, Cd, Hg, Ni, Pb, and Tl), essential metals (Na, Mg, K, Ca, Fe, Co, Mn, Cu, Zn, and Mo), essential non-metals (B, P, S, and Se), and other non-essential metals (Al, Ba, Li, and Sr)) are associated with CSF AD biomarkers that reflect pathological changes in the AD brain (amyloid β1–42, total tau, phosphorylated tau isoforms, NFL, S100B, VILIP-1, YKL-40, PAPP-A, and albumin). We used inductively coupled plasma mass spectroscopy (ICP-MS) to determine macro- and microelements in CSF and plasma, and enzyme-linked immunosorbent assays (ELISA) to determine protein biomarkers of AD in CSF. This study included 193 participants (124 with AD, 50 with mild cognitive impairment, and 19 healthy controls). Simple correlation, as well as machine learning algorithms (redescription mining and principal component analysis (PCA)), demonstrated that levels of heavy metals (As, Cd, Hg, Ni, Pb, and Tl), essential metals (Ca, Co, Cu, Fe, Mg, Mn, Mo, Na, K, and Zn), and essential non-metals (P, S, and Se) are positively associated with CSF phosphorylated tau isoforms, VILIP-1, S100B, NFL, and YKL-40 in AD.

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Section: Discussionmentioning

confidence: 87%

Heavy Metals and Essential Metals Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease

Leko

Mihelčić

Jurasović

et al. 2022

IJMS

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“…Interestingly, zinc levels do not significantly differ between the BDD group and HC, suggesting unique aspects of zinc metabolism or homeostasis in BD [60]. This lack of difference could reflect specific physiological or compensatory responses in BD related to zinc regulation, distinct from those in UD [29].…”

Section: 2mentioning

confidence: 83%

Serum Levels of Zinc, Albumin, Interleukin-6 and CRP in Patients with Unipolar and Bipolar Depression: Cross Sectional Study

Bagarić,

Mihaljević-Peleš,

Skočić Hanžek

et al. 2024

CIMB

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Unipolar (UD) and bipolar depression (BDD) show a high degree of similarity in clinical presentations, which complicates the differential diagnosis of these disorders. The aim of this study was to investigate the serum levels of interleukin 6 (IL-6), C-reactive protein (CRP), albumin (Alb), and zinc (Zn) in patients with UD, BDD, and healthy controls (HC). A total of 211 samples were collected: 131 patient samples (65 UD and 68 BDD) and 80 HC. The Montgomery–Asberg Depression Rating Scale (MADRS), along with the Hamilton Depression Rating Scale (HAMD-17), were administered to patient groups to evaluate symptoms. A cross-sectional study was performed to analyse the serum levels of IL-6, CRP, albumin, and zinc. The concentration of CRP was determined using the immunoturbidimetry method, zinc using the colorimetric method, and albumin using the colorimetric method with bromocresol green on the Alinity c device. IL-6 cytokine concentration in serum samples was ascertained using a commercial enzyme immunoassay, ELISA. We found no significant differences in serum concentrations of zinc, albumin, CRP, and IL-6 between the groups of patients with unipolar and bipolar depression. There was a significant statistical difference (p < 0.001) between serum levels of all investigated parameters in both groups of depressed patients in comparison with HC. Furthermore, correlations with specific items on HAMD-17; (namely, hypochondrias, work and activities, somatic symptoms-general, and weight loss) and on MADRS (concentration difficulties, lassitude) were observed in both patient groups. These findings confirm the presence of low-grade inflammation in depression, thus adding better insight into the inflammation hypothesis directed to explain the aetiology of depressive disorders. Our results do not indicate potential biomarkers for distinguishing between unipolar and bipolar depression.

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Serum concentration of zinc is elevated in clinically stable bipolar disorder patients

et al. 2021

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Background Bipolar disorder (BD) is a chronic psychiatric disorder characterized by recurrent mood episodes interspersed with euthymic periods. A growing number of studies have indicated that zinc plays an important role in coordinating immune responses, as well as being involved in synaptic transmission. In the current study, we set out to measure serum levels of zinc in a meticulously phenotyped cohort of 121 euthymic BD subjects and 30 matched controls. Methods Serum levels of zinc were measured by photometry. To assess the interplay between zinc levels and immune activation in BD, we measured serum levels of high‐sensitive C‐reactive protein (hsCRP) levels by immunoturbidimetric assay, and serum levels of monocyte chemoattractant protein‐1 (MCP‐1), chitinase 3‐like protein 1 (YKL‐40), and soluble cluster of differentiation 14 (sCD14) by electrochemiluminescence enzyme‐linked immunosorbent assays. The baseline clinical diagnostic instrument for BD was the Affective Disorder Evaluation, and executive functioning was assessed by using the Delis–Kaplan Executive Function System. Results Controlling for potential confounding factors, BD patients displayed increased serum levels of zinc unrelated to hsCRP, MCP‐1, YKL‐40, and sCD14 levels. Serum levels of zinc did not associate with executive functioning or measurements of disease severity. Discussion This study suggests that the zinc homeostasis is disturbed in BD and that this dyshomeostasis is not related to ongoing mood symptoms or immune activation. Of note, serum levels were increased and hence do not support continuous zinc supplementation in BD.

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Serum concentration of zinc is elevated in clinically stable bipolar disorder patients

Cited by 6 publications

References 45 publications

Heavy Metals and Essential Metals Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease

Heavy Metals and Essential Metals Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease

Serum Levels of Zinc, Albumin, Interleukin-6 and CRP in Patients with Unipolar and Bipolar Depression: Cross Sectional Study

Serum concentration of zinc is elevated in clinically stable bipolar disorder patients

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