Serum concentration of visfatin in obese women

Zahorska-Markiewicz, Barbara; Olszanecka-Glinianowicz, Magdalena; Janowska, Joanna; Kocełak, Piotr; Semik-Grabarczyk, Elżbieta; Holecki, Michał; Dąbrowski, Piotr; Skorupa, Anna

doi:10.1016/j.metabol.2007.04.007

Cited by 110 publications

(110 citation statements)

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“…The use of a more specific assay for visfatin/NAMPT determination showed that its level is not associated with glucose and insulin levels. This observation is inconsistent with our previously published data obtained with EIA 14 and supports the hypothesis that visfatin/NAMPT should be considered as a marker of inflammation not directly involved in the homeostasis of glucose metabolism.…”

Section: Number Of Ms Componentscontrasting

confidence: 99%

“…[11][12][13] Increased circulating visfatin/ NAMPT levels have also been reported in subjects diagnosed with obesity and those with MS criteria. 14,15 However, the association between visfatin/NAMPT levels and severity of MS understood as a number of its components has not been assessed so far. In addition, during the analysis of the published studies assessing visfatin/NAMPT levels, we noticed that most of them, including some of our own, estimated visfatin/NAMPT levels with the use of low specific C-terminal enzyme immunoassays (EIA developed by Phoenix Pharmaceuticals, Burlingame, California, United States) or radioimmunoassays, which reported the circulating levels of undefined protein with a molecular weight of ~500 kDa improperly considered as visfatin/NAMPT.…”

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confidence: 99%

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Plasma visfatin/nicotinamide phosphoribosyltransferase (visfatin/NAMPT) concentration in elderly subjects with metabolic syndrome

Kocełak¹,

Olszanecka-Glinianowicz²,

Owczarek³

et al. 2015

Polish Archives of Internal Medicine

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IntroductIon Visceral adipose tissue is the main source of circulating proinflammatory adipokine, visfatin/nicotinamide phosphoribosyltransferase (visfatin/NAMPT), whose role in the pathogenesis of metabolic syndrome (MS) components such as hypertension and carbohydrate and lipid disturbances is still uncertain, due to commonly used low specific C-terminal immunoassays to determine visfatin/ NAMPT levels.objectIves The aim of the study was to assess the association between the occurrence of MS components and circulating visfatin/NAMPT levels in elderly population.PAtIents And methods The analysis included 2174 elderly participants of the PolSenior study without heart failure, severe chronic kidney disease, cancer, and malnutrition. MS was defined according to the modified International Diabetes Federation criteria. Plasma visfatin/NAMPT concentrations were measured by a highly specific enzyme-linked immunosorbent assay. Additionally, high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), and insulin levels were assessed, and the homeostasis model assessment for insulin resistance was calculated.results Women were diagnosed with MS more often than men (71.2% vs 56.8%; P <0.001) and had a greater prevalence of all MS components except for type 2 diabetes. Women with MS had higher concentrations of hsCRP and IL-6 than those without MS. Visfatin/NAMPT concentrations were higher in women with MS than in those without MS (1.06 ng/ml [0.65-1.87] vs 0.85 ng/ml [0.54-1.40]; P <0.001), but no differences were observed in men (0.97 ng/ml [0.59-1.61] vs 0.90 ng/ml [0.56-1.60], respectively; P = 0.5). In women, there was a stronger association between the number of components of MS and increased plasma visfatin/NAMPT levels than in men.conclusIons Plasma visfatin/NAMPT levels are increased only in elderly women with MS. It is difficult to distinguish the components of MS specifically associated with increased visfatin/NAMPT levels. 403assay (ELISA) kits in plasma samples of a large group of elderly subjects, participants of the PolSenior study, 18 may provide new data on the role of visfatin/NAMPT in MS. In our recently published study, we have shown that plasma visfatin/NAMPT levels are associated with age, systemic microinflammation, and IR regardless of sex, and with nutritional status only in women. 19 The aim of the present study was to assess the association between the number and type of MS components and circulating plasma visfatin/ NAMPT levels in elderly population.PAtIents And methods study design and setting This substudy was based on 2733 banked samples from the PolSenior study 18 stored at -70°C. The PolSenior study conducted in the years 2008 and 2011 recruited 6 age cohorts of a similar size (65-69 years, 70-74 years, 75-79 years, 80-84 years, 85-89 years, and ≥90 years). Trained nurses visited a total of 4979 participants 3 times to conduct a questionnaire survey, comprehensive geriatric assessment, and body mass, height, waist circumference, and blood pressure (BP) measurements. In addi...

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Section: Number Of Ms Componentscontrasting

confidence: 99%

mentioning

confidence: 99%

Plasma visfatin/nicotinamide phosphoribosyltransferase (visfatin/NAMPT) concentration in elderly subjects with metabolic syndrome

Kocełak¹,

Olszanecka-Glinianowicz²,

Owczarek³

et al. 2015

Polish Archives of Internal Medicine

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“…In contrast, negative correlations between visfatin concentrations and LDL-cholesterol [40], HDLcholesterol and triglyceride [41] levels were reported. Zahorska-Markiewicz did not observe a correlation between visfatin concentrations and lipids in both the obese and lean groups [37]. The lack of correlation between visfatin levels and parameters of lipid metabolism in the FDRs group warrants further study.…”

Section: Discussionmentioning

confidence: 71%

“…Circulating visfatin concentration in relation to obesity is controversial [27,28,37,38]. In a recent study [39], visfatin/PBEF/Nampt mRNA levels were not correlated with measures of obesity, and the researchers suggested that visfatin is not predominantly secreted from visceral fat.…”

Section: Discussionmentioning

confidence: 99%

Serum visfatin and vaspin levels in normoglycemic first-degree relatives of Iranian patients with type 2 diabetes mellitus

Akbarzadeh

Nabipour

Jafari

et al. 2012

Diabetes Research and Clinical Practice

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“…Although, visfatin is linked to insulin receptors, the link is in a separate location from insulin and by binding to these receptors, it causes reduction in glucose release from the liver and stimulates glucose uptake in adipose cells and muscles (8). Plasma concentration of visfatin is increased in obese subjects (9,10) and those with type 2 diabetes (11). According to reports, an increase in insulin levels may be a compensatory mechanism for defects in insulin action (12).…”

Section: Introductionmentioning

confidence: 99%

Single and Concurrent Effects of Endurance and Resistance Training on Plasma Visfatin, Insulin, Glucose and Insulin Resistance of Non-Athlete Men with Obesity

Tayebi

Saeidi

Khosravi

2016

Ann. Appl. Sport Sci

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The purpose of the present study was to investigate the effect of endurance (ET), resistance (RT) and concurrent training (CT) on plasma levels of visfatin, insulin, glucose and insulin resistance of non-athlete men with Obesity. It was a semi-experimental study. Thirty six men [age: 21.48 (0.25), and BF%: 27.39 (0.52)], voluntarily participated in this study after public announcement in university. Main inclusion and exclusion criteria was healthy (no physical illness and inability), obesity [based on WHO's definition body fat percentage (BF%) of over 25] and non-athlete (without regular training during week). They were randomly divided into three groups (n=12) for ET, RT and CT. For 8 weeks (3sessions/week), the candidates participated in ET (25-40 min at 65-85% of maximum heart rate), RT (5exercises, 6sets, intensity: 50-80% of one repetition maximum, volumes: 5, 8 and 12repetitions) and CT (one or a half-term ET and then RT with 3 sets). Blood samples were taken 48 h before the first training session and 48 h after the last training session. The BF% in ET was significantly less than that in RT (p0.01), and in CT, it was less than that for both ET and RT (p0.01). Plasma visfatin only, in CT was significantly less than that in RT (p0.01). Plasma insulin levels in CT were significantly higher than that in ET and RT (p0.01). Plasma glucose levels in CT were less than that in ET and RT, significantly (p0.01). Insulin resistance only in CT was less than that in ET significantly (p0.01). In general, the present study showed that maybe, CT have more effect on the body composition, glucose metabolism and insulin resistance adjustment, which can be effective in preventing obesity and adjusting adipocytokines such as visfatin.

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Serum concentration of visfatin in obese women

Cited by 110 publications

References 13 publications

Plasma visfatin/nicotinamide phosphoribosyltransferase (visfatin/NAMPT) concentration in elderly subjects with metabolic syndrome

Plasma visfatin/nicotinamide phosphoribosyltransferase (visfatin/NAMPT) concentration in elderly subjects with metabolic syndrome

Serum visfatin and vaspin levels in normoglycemic first-degree relatives of Iranian patients with type 2 diabetes mellitus

Single and Concurrent Effects of Endurance and Resistance Training on Plasma Visfatin, Insulin, Glucose and Insulin Resistance of Non-Athlete Men with Obesity

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