Serum concentration of some acute phase proteins in naturally occurring canine babesiosis: a preliminary study

Ulutaş, Bülent; Bayramli, Goksel; Ulutaş, Pınar Alkım; Karagenç, Tülin

doi:10.1111/j.1939-165x.2005.tb00028.x

Cited by 51 publications

(50 citation statements)

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“…A significant difference (p < 0.01) was found between the groups on days 6 and 12 PI (Figure 2). It seems that an increase in ceruloplasmin levels would be an early indicator of the onset of inflammatory processes in dogs with hemorrhagic gastroenteritis (KOGIKA et al, 2003); in other diseases such as pyometra in bitches (FARIA JUNIOR, 2004), and in canine babesiosis (ULUTAS et al, 2005). This information agrees with our findings, in which the levels of ceruloplasmin peaked shortly after the experimental infection (D6), even before the onset of clinical signs.…”

Section: Resultssupporting

confidence: 83%

Experimental Ehrlichia canis infection changes acute-phase proteins

Munhoz

Faria

Vargas-Hérnandez

et al. 2012

Rev. Bras. Parasitol. Vet.

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Early diagnosis of canine ehrlichiosis favors prompt institution of treatment and improves the prognosis for the animal, since this disease causes mortality among dogs. Studies have shown that determining the concentration of acute-phase proteins (APPs) may contribute towards early detection of disease and aid in predicting the prognosis. This study aimed to evaluate the APP profile in dogs experimentally infected with Ehrlichia canis, at the start of the infection and after treatment. It also investigated whether any correlation between APP levels and the clinical and laboratory alterations over the course of the disease would be possible. The results obtained showed abnormal levels of all the APPs on the third day after infection (D3), with the highest levels being reached on D18, with the exception of ceruloplasmin and acid glycoprotein, which presented their peaks on D6 and D12 respectively. We concluded that assessment of APP levels could contribute towards establishing an early diagnosis of canine ehrlichiosis, particularly regarding acid glycoprotein and ceruloplasmin, since these proteins were detected at increased levels even before the onset of clinical and laboratory findings of the disease.Keywords: Ehrlichia canis, experimental infection, acute-phase proteins, dogs. ResumoO diagnóstico precoce da erliquiose canina favorece a pronta instituição do tratamento e melhora o prognóstico do animal, pois se trata de uma doença de alta mortalidade em cães. Estudos têm apontado que a determinação da concentração de proteínas de fase aguda (PFA) pode contribuir para detecção precoce de doenças e auxiliar na predição do prognóstico. O presente estudo objetivou avaliar o perfil de proteínas de fase aguda (PFA) em cães experimentalmente infectados com Ehrlichia canis, no início da infecção e após o tratamento. Além disso, se seria possível associá-las com as alterações clínico-laboratoriais durante o curso da doença. Os resultados obtidos evidenciaram que todas as PFA estudadas alteraram suas concentrações em D3 (dia 3), comparadas ao D0, atingindo concentrações máximas em D18, com exceção da ceruloplasmina e da glicoproteína ácida, cujos picos foram observados em D6 e D12, respectivamente. Concluímos que a avaliação das concentrações de PFA poderiam contribuir para o diagnóstico precoce da erliquiose canina, principalmente com relação à ceruloplasmina e glicoproteína ácida, pois seus aumentos foram anteriores ao aparecimento dos sinais clínicos e das alterações laboratoriais da doença.Palavras-chave: Ehrlichia canis, infecção experimental, proteínas de fase aguda, cães.

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Section: Resultssupporting

confidence: 83%

Experimental Ehrlichia canis infection changes acute-phase proteins

Munhoz

Faria

Vargas-Hérnandez

et al. 2012

Rev. Bras. Parasitol. Vet.

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“…Increased amounts of serum CRP, together with other acute phase proteins, have been demonstrated in canine babesiosis, confirming the presence of an acute inflammatory response (Ulutas et al, 2005;Matijatko et al, 2007;Köster et al, 2009). The latter study failed to find an association between serum CRP concentration and outcome in canine babesiosis (Köster et al, 2009).…”

Section: Discussionmentioning

confidence: 38%

Assessment of renal dysfunction using urinary markers in canine babesiosis caused by Babesia rossi

Defauw

Schoeman

Smets

et al. 2012

Veterinary Parasitology

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Renal damage is deemed a common, yet poorly documented, complication in canine babesiosis.Serum urea and creatinine are insensitive and non-specific markers of early renal dysfunction and 2 their measurements are influenced by hemolysis caused by babesiosis. Therefore, the aim of this study was to use urinary markers to assess the localization and degree of renal dysfunction in dogs with Babesia rossi infection. Urinary immunoglobulin G (uIgG) and urinary C-reactive protein (uCRP) were measured as markers for glomerular dysfunction, while urinary retinol-binding protein (uRBP) was used as a marker for tubular dysfunction. Eighteen dogs presenting with uncomplicated babesiosis were included and compared with eight clinically healthy dogs. Previously validated commercial ELISA kits were used for the measurement of uIgG, uCRP, and uRBP. Results were related to urinary creatinine concentrations (c). Dogs with babesiosis had significantly higher concentrations of all three measured urinary markers compared to healthy dogs. Except for urinary protein/c ratio (UPC), routine urinary and serum markers for renal function (urine specific gravity (USG), serum urea and creatinine (sCr)) were not significantly different between dogs with babesiosis and healthy dogs.All three urinary markers were positively correlated with each other and with UPC. The data supports the presence of both glomerular and tubular dysfunction in dogs suffering from uncomplicated B. rossi infection. Urinary markers were superior to USG, serum urea and creatinine concentrations for the early detection of renal dysfunction in dogs with babesiosis.

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“…Dogs with Babesia canis clinical signs of infection had signifi cantly higher CRP levels but signifi cantly lower levels of Hp. This fi nding indicates that the systemic infl ammation and haemolysis were caused by complicated babesiosis [20].…”

Section: Dogsmentioning

confidence: 99%

“…Approach to C-reactive protein and haptoglobin concentrations in infectious diseases in dogs [17,18,22,23,27,40,41,50] or haemolysis present in all severe cases [18]. Diminished plasma concentrations of Hp were reported in patients with various haemolytic diseases [19] and haemorrahage or haemolysis associated with haemolytic anaemia [20] as Hp has been identifi ed as the principal scavenger of free haemoglobin in the blood [21]. PON 1 activity was signifi cantly decreased in dogs with parvovirus enteritis with a high correlation with albumin possibly caused by the effects of infl ammatory cytokines in the liver [18].…”

Section: Dogsmentioning

confidence: 99%

Acute Phase Proteins as Markers of Infectious Diseases in small Animals / Proteini Akutne Faze Kao Markeri Infektivnih Bolesti Malih Životinja

Schmidt

Eckersall

2015

Acta Veterinaria

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During the acute phase response, there is an increased production and release of certain proteins known as acute phase proteins (APPs) which can be produced by hepatocytes and peripheral tissues such as C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin (Hp), alpha-1 acid glycoprotein (AGP). These proteins have been investigated as markers of various infectious diseases in small animals and the purpose of this review is to update the current knowledge about APPs in infectious diseases in dogs and cats.

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Serum concentration of some acute phase proteins in naturally occurring canine babesiosis: a preliminary study

Abstract: Results of this study suggest that acute phase protein concentrations could be beneficial in the diagnosis and determination of the severity of babesiosis in dogs.

Cited by 51 publications

References 19 publications

Experimental Ehrlichia canis infection changes acute-phase proteins

Experimental Ehrlichia canis infection changes acute-phase proteins

Assessment of renal dysfunction using urinary markers in canine babesiosis caused by Babesia rossi

Acute Phase Proteins as Markers of Infectious Diseases in small Animals / Proteini Akutne Faze Kao Markeri Infektivnih Bolesti Malih Životinja

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