Serum concentration of procoagulant, endothelial and oxidative stress                markers in early primary varicose veins

Yasım, Alptekin; Kılınç, Metin; Aral, Murat; Öksüz, Hafize; Kabalcı, Mehmet; Eroğlu, Erdinç; Imrek, Secil Simsek

doi:10.1258/phleb.2007.007014

Cited by 46 publications

(69 citation statements)

References 22 publications

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“…One study compared the systemic concentrations of procoagulant and endothelial markers in patients with primary varicose veins with those in healthy subjects and found no statistically significant differences in the plasma (systemic) levels of protein C, fibrinogen, tPA, IL-6, and NO between the study and control groups. 21 However, in that study, in contrast with the present study, circulating markers between different groups in systemic blood were compared and this finding does not exclude an increased local release of inflammatory markers and markers of endothelial damage. When they are diluted in systemic blood, significant differences can be masked and disappear.…”

Section: Endothelial Dysfunction and Varicose Veinscontrasting

confidence: 57%

“…The only report on the systemic levels of IL-6, from Yasim and co-workers, did not show significant differences in systemic levels of IL-6 between patients with varicose veins and healthy subjects. 21 In the present study, a borderline increase of neuron specific enolase (NSE) was found. This glycolytic enzyme is produced by neuronal and neuroendocrine cells and is used as a tumor marker of neuroendocrine cancers.…”

Section: Varicose Veins and Inflammationsupporting

confidence: 44%

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Do Blood Constituents in Varicose Veins Differ From the Systemic Blood Constituents?

Poredoš

Spirkoska

Ručigaj

et al. 2015

European Journal of Vascular and Endovascular Surgery

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Some inflammatory markers and indicators of endothelial dysfunction are increased in varicose vein blood. This is most probably the consequence of deteriorated blood flow in dilated and tortuous superficial veins, and increased venous pressure. Damage to the venous wall, which causes a chronic inflammatory response, together with the procoagulant properties of local blood may promote further progression of the disease and thrombotic complications.

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Section: Endothelial Dysfunction and Varicose Veinscontrasting

confidence: 57%

Section: Varicose Veins and Inflammationsupporting

confidence: 44%

Do Blood Constituents in Varicose Veins Differ From the Systemic Blood Constituents?

Poredoš

Spirkoska

Ručigaj

et al. 2015

European Journal of Vascular and Endovascular Surgery

View full text Add to dashboard Cite

show abstract

“…No statistically significant differences were found between the cases and controls. 7 The prevalence of raised procoagulant factors has not been studied in patients with VV.…”

mentioning

confidence: 99%

Higher prevalence of thrombophilia in patients with varicose veins and venous ulcers than controls

Darvall

Sam

Adam

et al. 2009

Journal of Vascular Surgery

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Patients with VV, and particularly CVU, have significantly higher prevalences of single and multiple thrombophilias than age- and sex-matched controls without clinical or duplex evidence of lower limb venous disease. These data support the hypothesis that thrombophilia predisposes to the development of superficial and deep lower limb venous reflux, and so VV and CVU, through the increased occurrence of clinical and subclinical thrombosis.

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“…The main factors in the etiology of varicose veins are associated with valvular incompetency and venous dilatation [13,14] . These cause relative hypoxia and venous stasis.…”

Section: Discussionmentioning

confidence: 99%

Elevation of both Reactive Oxygen Species and Antioxidant Enzymes in Vein Tissue of Infertile Men with Varicocele

Efe¹,

Kurutaş

Gul

et al. 2011

Urol Int

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Objective: To compare reactive oxygen species (ROS) and antioxidants in internal spermatic vein tissue of men with varicocele and a control group with inguinal hernia. Also to compare the levels of oxidants and antioxidants in infertile and fertile men with varicocele. Patients and Methods: 48 varicocele patients and 12 non-varicocele inguinal hernia patients participated in this study. The varicocele group was again divided into two groups – fertile men with varicocele and infertile men with varicocele. Internal spermatic vein tissue samples were obtained. The level of the malondialdehyde (MDA), an indicator of oxidative stress, and the activities of antioxidant enzymes (defense systems) against oxidative stress such as superoxide dismutase (SOD) and catalase (CAT) were estimated in these tissue samples. Results: The mean level of MDA in the varicocele group was significantly higher than in the hernia group, whereas the levels of antioxidants (SOD and CAT) were significantly lower in the varicocele group than in the hernia group. When compared with the subgroups of the varicocele group, the MDA levels and SOD and CAT activities were significantly higher in the infertile varicocele group than in the fertile varicocele group. Conclusions: Antioxidant enzyme levels generally decrease due to a high consumption in varicocele patients. On the contrary, in our study both MDA and antioxidant enzymes increased in the internal spermatic venous wall of infertile varicocele patients. This situation may be explained by an adaptation against oxidative stress in varicocele, which could be defined as a chronic process.

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Serum concentration of procoagulant, endothelial and oxidative stress markers in early primary varicose veins

Cited by 46 publications

References 22 publications

Do Blood Constituents in Varicose Veins Differ From the Systemic Blood Constituents?

Do Blood Constituents in Varicose Veins Differ From the Systemic Blood Constituents?

Higher prevalence of thrombophilia in patients with varicose veins and venous ulcers than controls

Elevation of both Reactive Oxygen Species and Antioxidant Enzymes in Vein Tissue of Infertile Men with Varicocele

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