Serum-Complement Levels in Hæmolytic-Uræmic Syndrome

In an attempt to further study the possible contribution of circulating immune complexes (CIC) in the pathogenesis of the classic form of hemolytic uremic syndrome, 9 patients were studied during the acute phase of the diseases. Clq solid-phase ELISA and conglutinin solid-phase ELISA, were used to measure the levels of immune complexes. All 9 were positive in one or both assays. No correlation was found between the levels of CIC and the clinical severity of the disease. The constant finding of positive CIC in these patients might represent an epipheno-menon, point out the postinfectious nature of this disease but also suggest a possible pathogenic role.

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“…The complement activation found in our patients, such as has been described previously [23,24], would be another evidence of its immune nature.…”

Section: Discussionsupporting

confidence: 87%

Presence of Circulating Immune Complexes in the Classic Form of Hemolytic Uremic Syndrome: A Constant Finding

Olavarría¹,

Mezzano²,

Ardiles³

et al. 1989

Nephron

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“…In children, enteric viral infections frequently precede the onset of the disease and there is evi dence of an association with mumps and certain Coxsackie viruses [1,5]. In addi tion, immune mechanisms involving com plement and immunoglobulin deposition in glomeruli and renal arterioles have been re ported [9,12,13]. Our patient had no evi dence of an underlying immunologic disor der either as a consequence of her marrow transplant or as an isolated phenomenon.…”

Section: Discussionmentioning

confidence: 67%

Hemolytic Uremic Syndrome after Bone Marrow Transplantation

et al. 1982

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“…C3 hypocomplementemia occurs in approximately one third of children with D + HUS [4], Kaplan et al [6] sug gested that a persistently low total serum complement level seemed to be associated with a poor prognosis. To our knowledge, our report is the first to suggest an association between leukocytosis and C3 hypocomplementemia in D + HUS.…”

Section: Discussionmentioning

confidence: 99%

Hypocomplementemia and Leukocytosis in Diarrhea-Associated Hemolytic Uremic Syndrome

Robson

Leung

Fick

et al. 1992

Nephron

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Sixty-eight children with diarrhea-associated hemolytic uremic syndrome (D + HUS) were retrospectively examined to assess clinical variables associated with the combination of leukocytosis and hypocomplementemia. There was a statistically significant association between the white blood cell count (WBC) and the level of the third component of the complement system (C₃). Children with both a low C₃ and a high WBC were significantly younger and required hospitalization for a significantly longer period of time. Although there were also trends to increases in the presence of anuria and central nervous system complications and in the duration of anuria, elevated WBC, thrombocytopenia, dialysis, and hemorrhagic colitis in children with both an elevated WBC and a low C₃, these changes did not achieve statistical significance. The presence of a low C₃ and an elevated WBC may indicate a subset of children with D + HUS with a more severe episode.

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Serum-Complement Levels in Hæmolytic-Uræmic Syndrome

Cited by 46 publications

References 5 publications

Presence of Circulating Immune Complexes in the Classic Form of Hemolytic Uremic Syndrome: A Constant Finding

Presence of Circulating Immune Complexes in the Classic Form of Hemolytic Uremic Syndrome: A Constant Finding

Hemolytic Uremic Syndrome after Bone Marrow Transplantation

Hypocomplementemia and Leukocytosis in Diarrhea-Associated Hemolytic Uremic Syndrome

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