Presence of Circulating Immune Complexes in the Classic Form of Hemolytic Uremic Syndrome: A Constant Finding

Abstract

In an attempt to further study the possible contribution of circulating immune complexes (CIC) in the pathogenesis of the classic form of hemolytic uremic syndrome, 9 patients were studied during the acute phase of the diseases. Clq solid-phase ELISA and conglutinin solid-phase ELISA, were used to measure the levels of immune complexes. All 9 were positive in one or both assays. No correlation was found between the levels of CIC and the clinical severity of the disease. The constant finding of positive CIC in these patients might represent an epipheno-menon, point out the postinfectious nature of this disease but also suggest a possible pathogenic role.

A Study on the Antigenic Nature of Circulating Immune Complexes in Hemolytic Uremic Syndrome: No Evidence of Platelet Membrane Glycoprotein Antigens

“…Furuse et al [6] later en countered CIC in 1 patient with sporadic HUS. Moreover, in a recent study we have found CIC as a constant finding in Accepted: February 18,1993 classical HUS, suggesting a probable immunopathogenic role [7].…”

“…This technique has been previously reported [7,9]. The procedure used was basically that of C'asali et al [10] with minor changes.…”