Serum complement level in workers exposed to benzene, toluene and xylene

Smolik, R; Grzybek-Hryncewicz, K; Lange, Andrzej; Zatoński, Witold

doi:10.1007/bf00539244

Cited by 34 publications

(19 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study among workers exposed to benzene concentrations lower than 15 ppm, depression of the circulating B-lymphocyte level was induced (14). Other disparate and immunologic effects in workers exposed to solvents have been described (15)(16)(17)(18). In a study in mice, immunotoxicity induced by benzene treatment alone was characterized by involution of thymic mass and suppression of both B-and T-cell mitogenesis (19).…”

Section: Resultsmentioning

confidence: 99%

Exposure to Solvents and Risk of Non-Hodgkin Lymphoma: Clues on Putative Mechanisms

Víneis

Miligi²,

Costantini³

2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Malignant lymphomas are a group of diseases of uncertain etiology. Both environmental factors and genetic susceptibility have been reported as risk factors. We have conducted a population-based case-control study in Italy: all newly diagnosed cases of malignant lymphoma, in males and females ages 20 to 74 years in the 1991 to 1993 period, were identified; the control group was comprised of a random sample of the general population resident in each of the areas under study, stratified by sex and 5-year age groups. Overall, 1,428 non -Hodgkin lymphoma (NHL) cases and 1,530 controls were interviewed. Experts from each geographic area examined questionnaire data and assigned a level of probability and intensity of exposure to a range of chemical groups and individual chemicals. For those in the medium/high level of exposure, there was an increased risk of NHL for exposure to benzene, xylene, and toluene. We have examined the hypothesis that the effect of solvents is related to their immunotoxicity by analyzing the interaction with a previous history of autoimmune disease. We have found an apparent, though not statistically significant, increased risk of NHL in those with both exposure to benzene and a history of autoimmune disease (odds ratio, 16.3; 95% confidence interval, 0.8-321). In addition, an odds ratio of 29.8 (95% confidence interval, 1.4-650.2, based on nine exposed cases) was associated with high-level exposure to benzene in those with a positive family history of malignant hematologic neoplasms. Both hypotheses (i.e., the interaction with autoimmune diseases and with familial predisposition) indirectly suggest that an immunologic mechanism could be involved in lymphomagenesis from solvents. (Cancer Epidemiol Biomarkers Prev 2007;16(3):381 -4)

show abstract

Section: Resultsmentioning

confidence: 99%

Exposure to Solvents and Risk of Non-Hodgkin Lymphoma: Clues on Putative Mechanisms

Víneis

Miligi²,

Costantini³

2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…Decreased lymphocyte and serum complements were detected in workers who had been heavily exposed to xylene (8). Studies reveal adverse effects such as a decrease in the weight of the thymus and spleen in rats exposed to 2,000 mg/kg of xylene daily (1).…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that chronic occupational exposure to xylene is associated with a variety of hematological effects (6). Decreased white blood cell counts were observed in two women with chronic occupational exposure to xylene (7,8). Langman et al .…”

Section: Introductionmentioning

confidence: 99%

Xylene Induces Oxidative Stress and Mitochondria Damage in Isolated Human Lymphocytes

2017

View full text Add to dashboard Cite

Xylene is a cyclic hydrocarbon and an environmental pollutant. It is also used in medical technology, paints, dyes, polishes and in many industries as a solvent; therefore, an understanding of the interaction between xylene and human lymphocytes is of significant interest. Biochemical assessment was used to demonstrate that exposure of lymphocytes to xylene induces cytotoxicity (at 6 hr), generates intracellular reactive oxygen species, collapse of mitochondrial membrane potential, lysosomal injury, lipid peroxidation and depletion of glutathione (at 3 hr). The findings show that xylene triggers oxidative stress and organelle damage in lymphocytes. The results of our study suggest that the use of antioxidant, mitochondrial and lysosomal protective agents can be helpful for individuals subject to chronic exposure to xylene.

show abstract

“…These effects include reduced serum immunoglobulins [72,[80][81][82], an anti-benzene antibody response [83] and reduced complement levels [84].…”

Section: Hematotoxicity Caused By Chronic Benzene Exposure -Bone Marrmentioning

confidence: 99%

Effects Of Benzene on Human Hematopoiesis

Kirkeleit¹,

Riise²,

Gjertsen³

et al. 2008

TOHJ

View full text Add to dashboard Cite

Benzene, an aromatic hydrocarbon that is a natural component of crude oil and natural gas, is toxic to the blood and blood-forming organs. Epidemiological studies have established an association between benzene exposure and acute myeloid leukemia, and increasing evidence also indicates a possible association between benzene and multiple myeloma. A specific benzene-associated myelodysplastic syndrome has also been suggested. Chronic hematotoxic effects of benzene exposure, including reduced lymphocyte, neutrophil and platelet counts in peripheral blood, have been detected at occupational exposure below a level that had previously been considered not to cause any health effects. Whether these abnormalities represent bone marrow damage and/or initial events in the development of a true neoplastic disease is not known. Together with a reported nonlinear relationship between benzene exposure and the level of various metabolites, favoring production of biologically reactive quinones at exposure below 1 part per million, these observations suggest that benzene even at low exposure levels may contribute to the risk of acute myeloid leukemia or myelodysplastic syndrome, especially among genetically susceptible individuals.

show abstract

Serum complement level in workers exposed to benzene, toluene and xylene

Cited by 34 publications

References 10 publications

Exposure to Solvents and Risk of Non-Hodgkin Lymphoma: Clues on Putative Mechanisms

Exposure to Solvents and Risk of Non-Hodgkin Lymphoma: Clues on Putative Mechanisms

Xylene Induces Oxidative Stress and Mitochondria Damage in Isolated Human Lymphocytes

Effects Of Benzene on Human Hematopoiesis

Contact Info

Product

Resources

About