Serum clusterin level in children with atopic dermatitis

Sol, In Suk; Kim, Yoon Hee; Lee, Jun Young; Hong, Jung Yeon; Kim, Seung Up; Kim, Yun Seon; Oh, Mi Seon; Kim, Min Jung; Yoon, Seo Hee; Park, Young A; Kim, Kyung Won; Sohn, Myung Hyun; Kim, Kyu-Earn

doi:10.2500/aap.2016.37.3953

Cited by 13 publications

(8 citation statements)

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“…In detail, four studies were published in the 1990s, nine in the 2000s, and 21 in the last decade. Different geographical areas (and ethnicities) were not uniformly represented: 16 studies [17,18,23,24,27,[32][33][34][35][36][37][38]40,42,45,46] were performed in Eastern Asia (8 in Japan, 6 in Korea, 2 in Taiwan), nine [21,28,31,39,41,43,44,47,48] in Europe (3 in Russia, 2 in Germany, 1 in Finland, Italy, Norway, Switzerland), four [20,22,29,30] in Middle Eastern countries (3 in Turkey, 1 in Israel), two [25,26] in Southern Asia (Bangladesh, India), and one [49] in the United States of America. Another study [19] included patients from multiple Canadian and European centers.…”

Section: Resultsmentioning

confidence: 99%

“…Another study [19] included patients from multiple Canadian and European centers. Sample sizes were often small: ten papers [18,21,29,31,33,35,44,46,48,49] reported data concerning a population of less than 20 AD patients, eight papers [26,28,36,37,39,42,45,47] examined 20 to 40 patients, and only in seven cases [19,23,24,32,34,38,41,43] the number of patients was 100 or more. AD patients were adults (age >18 years) in seven studies, children in 19 (in four cases, patients were of neonatal age), both adults and children in eight.…”

Section: Resultsmentioning

confidence: 99%

“…Many other parameters related to oxidative stress were evaluated in only one of the papers corresponding to the selection criteria used for this review. In the serum of AD patients, significantly elevated levels of clusterin (correlated with disease severity) [24], significantly decreased levels of beta carotene [34], catalase [26], gamma tocopherol [39], glutathione peroxidase [26], Mg [30], NO [22], retinol [34], and levels of Cu similar to those of healthy controls [30] were found. Decreased also were, in AD patients, the serum total antioxidant capacity [38], serum disulphide, disulphide/native thiol ratio and disulphide/total thiol ratio [20], NO/melatonin ratio [22], nitrite/nitrate (NO x -) [45].…”

Section: Biomarkersmentioning

confidence: 99%

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Oxidative Stress and Atopic Dermatitis

et al. 2020

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Atopic dermatitis is a common chronic/chronically relapsing inflammatory skin disease, with increasing worldwide prevalence. Etiopathogenesis is complex and multifactorial, with a mix of genetic, immunological and environmental aspects. Like in other chronic inflammatory diseases, oxidative stress plays an important pathogenetic role. We reviewed in vivo research studies on humans about oxidative stress and atopic dermatitis. Although sometimes contrasting, overall, they suggest that oxidative stress may have a significant role in atopic dermatitis, but our understanding is still incomplete, at least concerning in vivo data, because of limitations of available literature. Research consists of 33 papers published in 28 years, was not always performed on large study populations, represents a limited number of countries and ethnicities—not always in proportion to their size—and is scattered over multiple papers that, in the majority of cases, cannot be pooled and/or compared because many biomarkers were studied, in different tissues and with different methods. Further, larger studies appear warranted and necessary to shed more light on this aspect of atopic dermatitis, which is important not only to improve our understanding of this disease, but also for potential clinical and therapeutic implications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Biomarkersmentioning

confidence: 99%

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Oxidative Stress and Atopic Dermatitis

et al. 2020

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“…Various cellular stress stimuli have been shown to regulate transcriptional activity of AP-1 [223]. Differential CLU expression was similarly observed in other oxidative stressrelated pathologies including asthma [224], atopic dermatitis [225], diabetes type 2 [226], coronary heart disease [226], and cancer [227]. Oxidative stress increases CLU expression.…”

Section: Clusterinmentioning

confidence: 91%

Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer’s Disease

Cioffi

Adam

Broersen

2019

JAD

139

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Alzheimer's disease is the most common neurodegenerative disorder that can cause dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress which interconnects with other processes such as amyloid-␤ deposition, tau hyperphosphorylation, and tangle formation. This review discusses current thoughts on molecular mechanisms that may relate oxidative stress to Alzheimer's disease and identifies genetic factors observed from in vitro, in vivo, and clinical studies that may be associated with Alzheimer's disease-related oxidative stress.

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“…In transitioning to atopic dermatitis, Sol et al 13 investigated serum levels of clusterin, a small heat shock protein associated with the clearance of cellular debris and apoptosis, as a potential predictive biomarker of the disease in 140 children with atopic dermatitis. Their findings indicated that serum clusterin may be a candidate molecule that reflects the severity of the disease.…”

mentioning

confidence: 99%