Serum Cholinesterase Deficiency Ii: Pregnancy

Robertson, Graham

doi:10.1093/bja/38.5.361

Cited by 36 publications

(9 citation statements)

References 21 publications

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“…26,27 A decrease of total BChE activity was also reported during pregnancy when an increased synthesis of estrogens occurs. [28][29][30][31] So, the higher mean E 2 level found in the CHE2 C5 þ obese individuals of the present study when compared to the CHE2 C5 þ controls and to the CHE2 C5À obese individuals (Table 1) may be the reason why the CHE2 C5 þ obese patients did not show the expected significantly higher mean BChE activities when compared to each of these two groups ( Table 2).…”

Section: Discussionmentioning

confidence: 68%

Butyrylcholinesterase and obesity in individuals with the CHE2 C5+ and CHE2 C5− phenotypes

et al. 2003

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OBJECTIVE:To investigate the association between butyrylcholinesterase (BChE) activities (total and band specific) and body mass index (BMI) in obese and nonobese individuals, considering other variables (anthropometric, biochemical and hormonal) and the leanness process. SUBJECTS: Obese (BMIZ30 kg/m 2 ; N ¼ 181) and nonobese individuals (N ¼ 265), classified according to the CHE2 locus phenotypes, with the obese patients being followed-up when submitted to a weight-loss program. MEASUREMENTS: Anthropometric (weight, height, BMI, waist, waist/hip ratioFWHR, triceps and subscapular skinfolds, percentage of body fat and arterial pressures), hormonal (insulin, estradiolFE 2 , triiodothyronineFT 3 and thyroxineFT 4 ) and biochemical (glucose, total cholesterol, HDL-C, triglycerides, uric acid, urea, creatinine, sodium, potassium and BChE activities) variables. RESULTS: Although obese CHE2 C5À individuals presented higher mean BChE activities than their CHE2 C5À controls and diminished mean activities with leanness, similar comparisons did not show any difference in the CHE2 C5 þ group. Furthermore, the mean serum potassium values of obese individuals were significantly higher in the CHE2 C5 þ than in the CHE2 C5À phenotype. The BChE activities were less related to BMI in obese CHE2 C5À individuals than in their controls. In the CHE2 C5À obese group, significant regression coefficients were found between BChE activity variables and BMI ( þ ), ethnic origin (higher in Euro-Brazilians), sex (higher in males), diastolic pressure (À), triceps skinfold ( þ ), total cholesterol ( þ ), T 3 ( þ ) and E 2 (À). The main findings in the CHE2 C5 þ obese group: mean insulin levels decreased with leanness and a significant correlation was detected between the C 5 complex activity and creatinine ( þ ), insulin (À) and WHR (À); a significantly higher frequency of weight loss occurred compared to the CHE2 C5À group. CONCLUSION: In the present study, different relations between obesity and some of the studied variables were found when CHE2 C5 þ and CHE2 C5À individuals were compared.

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Section: Discussionmentioning

confidence: 68%

Butyrylcholinesterase and obesity in individuals with the CHE2 C5+ and CHE2 C5− phenotypes

et al. 2003

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“…The negative correlation of BChEA with estradiol is supported by data showing a higher mean value for BChEA in men than in females during their fertile period, a difference that disappears after menopause (35). Decrease of total BChE activity was also reported during pregnancy, when an increased synthesis of estrogens occurs (36,37).…”

Section: Butyrylcholinesterase and Diabetes Mellitusmentioning

confidence: 81%

Butyrylcholinesterase and diabetes mellitus in the CHE2 C5- and CHE2 C5+ phenotypes

Cwiertnia

Alcântara

Réa

et al. 2010

Arq Bras Endocrinol Metab

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Objective: To investigate the relationship between butyrylcholinesterase (BChE) activities (total and band specific) and diabetes mellitus. Subjects and methods: BChE activities (BChEA, AC 4/5 , AC OF and RC 5 ) were analyzed in 101 type 1 (DM1) and in 145 type 2 (DM2) diabetic patients, in relation to phenotype, weight and incidence of metabolic syndrome (MS) in these patients. The C 4/5 and C 5 complex were separated from other molecular forms (C OF ) using an acid agar gel. Results: The BChE activity (BChEA) and the absolute activities of C 4/5 (AC 4/5 ) and C OF (AC OF ) showed a high positive correlation coefficient to weight in the CHE2 C5-group, while the relative activity of C 5 complex (RC 5 ) showed a negative correlation to weight. Conclusions: The present study suggests that the positive correlation of the BChE activities to diabetes mellitus and to insulin resistance may depend on the CHE2 locus variability. High values of BChE activities were associated with insulin resistance only in CHE2 C5-diabetic patients, while in CHE2 C5+ diabetic patients, the presence of C 5 complex, especially in a relatively high proportion, leads to less fat storage and better protection against metabolic syndrome. Arq Bras Endocrinol Metab. 2010;54(1):60-7 Keywords BCHE and CHE2 loci; C 4/5 and C 5 complexes; obesity, insulin resistance; metabolic syndrome; serum cholinesterase RESUMO Objetivo: Investigar a associação entre as atividades (total e banda específica) da butirilcolinesterase (BChE) e diabetes melito. Sujeitos e métodos: As atividades da BChE (BChEA, AC 4/5 , AC OF e RC 5 ) foram analisadas em 101 pacientes diabéticos do tipo 1 (DM1) e 145 do tipo 2 (DM2) em relação aos fenótipos, ao peso e à incidência da síndrome metabólica. Os complexos C 4/5 e C 5 foram separados das outras formas moleculares (C OF ), usando gel de ágar ácido. Resultados: A atividade da BChE (BChEA) e as atividades absolutas de C 4/5 (AC 4/5 ) e de C OF (AC OF ) mostraram altos coeficientes de correlações positivos com peso no grupo de CHE2 C5-, enquanto a atividade relativa do complexo C 5 (RC 5 ) mostrou correlação negativa com o peso. Conclusões: O presente estudo sugere que as correlações positivas das atividades da BChE com diabetes melito e com a resistência à insulina podem depender da variabilidade do loco CHE2. Altos valores nas atividades da BChE estão associados com a resistência à insulina somente nos pacientes diabéticos CHE2 C5-, enquanto nos pacientes diabéticos CHE2 C5+ a presença do complexo C 5 , especialmente em alta proporção relativa, leva a um menor estoque de gordura e à maior proteção contra a síndrome metabólica. Arq Bras Endocrinol Metab. 2010;54(1):60-7 DescritoresLocos BCHE e CHE2; complexos C 4/5 e C 5 ; obesidade, resistência à insulina; síndrome metabólica; colinesterase do soro

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“…There is a decrease in plasma cholinesterase activity of about 20% in the first trimester of pregnancy and this reduction is maintained until delivery [40]. Two to 4 days after delivery there is a further 33% reduction in activity [41] and it is by the sixth postpartum week that there is return to prepregnancy levels.…”

Section: Physiological Variationsmentioning

confidence: 99%

Cholinesterase Its significance in anaesthetic practice

1997

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SummaryPlasma cholinesterase is an enzyme which has importance to the anaesthetist primarily for its rôle in the metabolism of suxamethonium, although other anaesthetic related drugs that this enzyme metabolises are also increasingly important. In this article we review current thoughts on the function, profile and chemistry of plasma cholinesterase. Causes of variations in the activity of the enzyme are described and the basis of genetic variations is explained.

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Serum Cholinesterase Deficiency Ii: Pregnancy

Cited by 36 publications

References 21 publications

Butyrylcholinesterase and obesity in individuals with the CHE2 C5+ and CHE2 C5− phenotypes

Butyrylcholinesterase and obesity in individuals with the CHE2 C5+ and CHE2 C5− phenotypes

Butyrylcholinesterase and diabetes mellitus in the CHE2 C5- and CHE2 C5+ phenotypes

Cholinesterase Its significance in anaesthetic practice

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