Serum Cholesterol Level Is Associated with the Severity of Carotid Stenosis in Symptomatic Patients: Results from NASCET

Gasecki, Andrew P.; Eliasziw, Michael; Fox, Allan J.; Hachinski, Vladimir; Barnett, H. J. M.

doi:10.1159/000108523

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…Though there are many investigations, CT and MRI play major role in the diagnosis of stroke. 5 Though MRI is superior to CT scan, the higher cost of the MRI, and the easy availability of CT scan brain makes CT the commonest investigation in diagnosis and treatment of stroke. 5 CT plays a major role in Stroke to assess site, size and nature of the lesion.…”

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confidence: 99%

“…5 Though MRI is superior to CT scan, the higher cost of the MRI, and the easy availability of CT scan brain makes CT the commonest investigation in diagnosis and treatment of stroke. 5 CT plays a major role in Stroke to assess site, size and nature of the lesion. Arteriographic and necropsy studies show that occlusion of the cerebral and extracerebral arteries are the frequent cause of ischemia and infarction Extra cranial carotid disease due to arteriosclerosis is usually associated with hypercholesterolemia and hyperlipidemia.…”

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confidence: 99%

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A study on prevalence of carotid artery stenosis in acute ischaemic stroke patients in Amalapuram, Andhra Pradesh, India

Bharathi¹,

Gullapalli²

2019

Int J Res Med Sci

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Background: Extra cranial carotid disease due to arteriosclerosis is usually associated with hypercholesterolemia and hyperlipidemia. Extra cranial carotid stenosis has been found to be less prevalent in black American and in Egyptians while intracranial disease is far more common Various methods includes transcranial doppler (TCD) ultrasonography, cerebral angiography, computed tomography angiography (CTA) and magnetic resonance angiography (MRA).Methods: All patients with ischaemic stroke of acute onset admitted in the medical wards of Konaseema institute of medical sciences between June 2018 and January 2019 were included in the study. All patients were subjected to CT scan brain study and colour Doppler study of extra cranial carotid arteries and vertebral arteries. Systolic and diastolic velocity of blood flow, carotid intimal medial thickness, presence of athermanous plaque and thrombus was looked for and then the percentage of stenosis of the affected arteries was calculated.Results: In the present study 0ut of 23 patients with carotid stenosis 9 patients had mild carotid stenosis, 8 patients had moderate stenosis and 6 patients had severe stenosis. Out of 23 patients with carotid stenosis the 11 patients have stenosis in the right carotid and 12 patients had stenosis in the left side. The site of stenosis is ICA in 17 patients and CCA in 6 patients.Conclusions: In present study every patient with carotid artery stenosis had one or the other risk factor for carotid atherosclerosis. In other words, there was no patient with carotid artery stenosis, without any risk factor in present study. Hence asymptomatic patients with these risk factors should be screened for carotid stenosis to prevent stroke.

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confidence: 99%

A study on prevalence of carotid artery stenosis in acute ischaemic stroke patients in Amalapuram, Andhra Pradesh, India

Bharathi¹,

Gullapalli²

2019

Int J Res Med Sci

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“…Various risk factors are known to contribute to the atherosclerosis of the carotid artery. Hypertension, 20 diabetes mellitus, 21 smoking, 17 and hyperlipidemia 18 promote atherosclerosis. Sueyoshi et al 22 reported that serum cholesterol is an important risk factor in the progression of carotid atherosclerosis.…”

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confidence: 99%

The Relationship Between the Angiographic Findings and the Clinical Features of Carotid Artery Plaque

Kim

Lee

et al. 2000

Surg Today

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The purpose of this study was to investigate the histological characteristics of atheromatous carotid plaque, and to analyze the relationship between the angiographic findings and the clinical features. We retrospectively reviewed 55 cases of carotid endarterectomy for extracranial internal carotid artery stenosis, who were treated at our institute from January 1995 to December 1997. The histological examination included hematoxylin-eosin staining, Masson-trichrome staining, and immunostaining for antismooth muscle antibody and anti-CD68 antibody. The main compositions of the carotid plaque included synthetic type vascular smooth muscle cells and extracellular matrix. The histological findings showed ulceration in 49 (89.1%) cases, calcium deposits in 42 (76.4%) cases, and an inflammatory reaction in 44 (80.0%) cases. Neurological abnormalities were strongly associated with plaque ulceration (P = 0.045) and an inflammatory reaction (P = 0.013), whereas no correlation existed regarding calcium deposits (P = 0.173). The angiographic findings showed ulceration in 46 (83.6%) cases. Plaque ulceration in the angiography findings showed no statistically significant correlation with the histologic findings (P = 0.410) and preoperative neurologic abnormalities (P = 0.059). All of the atherosclerotic risk factors such as hypertension, smoking, diabetes mellitus, hyperlipidemia, and myocardial infarction had no statistically significant correlation with the histological features of the carotid plaque. In conclusion, the main compositions of carotid plaque were synthetic-type vascular smooth muscle cells and extracellular matrix. The histological ulceration and inflammatory reaction of the plaque showed a statistically significant correlation with the preoperative neurologic symptoms, whereas no correlation was seen in the calcium deposits. Angiographic ulceration showed no correlation with the histological findings or preoperative neurologic abnormalities. In addition, the histological findings showed no correlation with the atherosclerotic risk factors.

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“…Hence, asymptomatic patients with these risk factors should be screened for carotid stenosis to prevent stroke/TIA. (15) 5. Hyperlipidemia and Carotid Stenosis: In our study, the prevalence of patients with carotid stenosis with increased cholesterol (> 200mg/dl), increased TGL (>150mg/dl), decreased HDL (<40 mg/dl) and increased LDL (>130 mg/dl) were 76.6%, 90%, 86% and 68.4% respectively.…”

Section: Smoking and Carotid Stenosismentioning

confidence: 99%

Evaluation of Carotid Artery Stenosis in Stroke/Transient Ischaemic Attack

Subramanyam¹,

P²,

Vakrani³

2015

jemds

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BACKGROUND: Stroke remains the second leading cause of death worldwide, after ischaemic heart disease. Patients with carotid artery stenosis are at higher risk of development of stroke. Carotid atherosclerosis occurs in patients with atherosclerotic risk factors like diabetes mellitus, hypertension, smoking and hyperlipidemia. Carotid artery stenosis can be assessed by means of noninvasive high-resolution B-mode ultrasonography of the carotid arteries. AIMS AND OBJECTIVES: 1). To estimate the prevalence of carotid artery stenosis in ischaemic stroke/transient ishaemic attack patients. 2). To estimate whether there was any association between carotid artery stenosis and important risk factors such as diabetes mellitus, hypertension, hyper lipidemia with control group. METHODS AND MATERIALS: Acute ischaemic/TIA stroke patients with CT-Brain showing infarcts were enrolled for the study. All patients were subjected to CT scan brain study and colour Doppler study of extracranial carotid arteries. The systolic and diastolic velocity of blood flow, and the ratio of peak systolic velocities of common carotid arteries were assessed. RESULTS: DM, HTN, Smoking & Hyperlipidemia acted as risk factors for carotid stenosis. The prevalence of carotid stenosis in our study was 60%. The prevalence of mild, moderate and severe stenosis were 34%, 10% and 16% respectively. The distribution of carotid stenosis was equal on both sides. The statistical significance was calculated using Chi-square test. Statistical significance was taken when P value was <0.05. Statistical analysis was carried using standard formulae. Microsoft Excel 2007 and SPSS (Statistical Package for Social Sciences) Version 17.0 software were used for data entry and analysis. CONCLUSIONS: Carotid stenosis was one of the common causes of ischaemic stroke. There was a statistically significant correlation between increasing age, male gender, smoking, diabetes mellitus, hypertension and hyperlipidemia and the prevalence of carotid stenosis. KEYWORDS: Carotid artery stenosis, Stroke, Ultrasonography. INTRODUCTION:Stroke remains the second leading cause of death worldWide 1 , after ischaemic heart disease. 85% of stroke cases are due to infarction and 15% are due to haemorrhagic. Patients with carotid artery stenosis are at higher risk of development of stroke and recurrence of stroke after a stroke/TIA. 2 Carotid atherosclerosis occurs in patients with atherosclerotic risk factors like diabetes mellitus (DM), hypertension (HTN), smoking and hyperlipidemia.Carotid atherosclerosis leads to plaque formation and these plaques gradually increase in size and cause stenosis. Atherosclerotic plaques interrupt the endothelium and then ulcerate. As the endothelium is breached, platelets adhere to the wall and a hemostatic plug is formed. This platelet nidus initiates coagulation cascade and an occlusive thrombus is formed. 2 Thrombus formation on an atherosclerotic plaque leads to distal embolisation and causes occlusion of blood vessels (Or) a severe stenosis may cau...

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Serum Cholesterol Level Is Associated with the Severity of Carotid Stenosis in Symptomatic Patients: Results from NASCET

Cited by 4 publications

References 14 publications

A study on prevalence of carotid artery stenosis in acute ischaemic stroke patients in Amalapuram, Andhra Pradesh, India

A study on prevalence of carotid artery stenosis in acute ischaemic stroke patients in Amalapuram, Andhra Pradesh, India

The Relationship Between the Angiographic Findings and the Clinical Features of Carotid Artery Plaque

Evaluation of Carotid Artery Stenosis in Stroke/Transient Ischaemic Attack

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