Serum Cholesterol Level and Mortality Findings for Men Screened in the Multiple Risk Factor Intervention Trial

Neaton, James D.; Blackburn, Henry; Jacobs, David R.; Kuller, Lewis H.; Lee, Duck Joo; Sherwin, Roger; Shih, Joanna H.; Stamler, Jeremiah; Wentworth, Deborah

doi:10.1001/archinte.1992.00400190110021

Cited by 551 publications

(171 citation statements)

References 76 publications

Supporting

Mentioning

149

Contrasting

Unclassified

Order By: Relevance

“…Results from some studies have suggested that patients with very low serum cholesterol levels have a higher risk of suicide and mortality, [249][250][251] and that patients receiving medication to reduce serum cholesterol levels have a higher risk of death from trauma, suicide and homicide. [252][253][254] However, 4-year follow-up results from 559 patients receiving pravastatin and 571 receiving placebo concluded that there is no association between long-term statin-induced reductions in serum cholesterol level and measures of anxiety, depression or anger.…”

Section: Disutility Due To Statin Treatmentmentioning

confidence: 99%

A systematic review and economic evaluation of statins for the prevention of coronary events

Ward

Jones²,

Pandor³

et al. 2007

Health Technol Assess

346

312

View full text Add to dashboard Cite

Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment ProgrammeT he Health Technology Assessment (HTA) Programme, now part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the costs, effectiveness and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined to include all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care, rather than settings of care. The research findings from the HTA Programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA Programme is needs-led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. First is the commissioned route. Suggestions for research are actively sought from people working in the NHS, the public and consumer groups and professional bodies such as r...

show abstract

Section: Disutility Due To Statin Treatmentmentioning

confidence: 99%

A systematic review and economic evaluation of statins for the prevention of coronary events

Ward

Jones²,

Pandor³

et al. 2007

Health Technol Assess

346

312

View full text Add to dashboard Cite

show abstract

“…Low cholesterol levels have been associated with increased mortality from hemorrhagic stroke, cancer, other noncardiovascular diseases, injury, and suicide in several observational studies and clinical trials. [7][8][9][10][11][12][13][14][15][16] A causal relation between low cholesterol levels and mortality has not been demonstrated. Other possible reasons for this association include a fall in cholesterol levels with the onset of disease and the presence of occult diseases in persons with low cholesterol levels on entry to these studies.…”

Section: Discussionmentioning

confidence: 99%

“…Meta-analyses of the cholesterollowering studies have shown higher mortality rates from accidental deaths, cancer, and noncardiovascular causes in subjects with total cholesterol levels (TC) Ͻ160 mg/dL. [7][8][9][10][11][12][13][14][15][16] However, these studies are limited in their design, and the low cholesterol may be secondary to undetected cancer, gastrointestinal disease, liver disease, weight loss, and alcoholism.…”

mentioning

confidence: 99%

Frequency of ApoB and ApoE Gene Mutations as Causes of Hypobetalipoproteinemia in the Framingham Offspring Population

Welty

Lahoz

Tucker

et al. 1998

ATVB

View full text Add to dashboard Cite

Abstract-Hypobetalipoproteinemia (HBLP) is characterized by plasma concentrations of apolipoprotein B (apoB) and low density lipoprotein cholesterol (LDL-C) below the fifth percentile. Some forms of HBLP have been shown to be due to truncated forms of apoB-100. A total of 3873 subjects participating in the Framingham Offspring Study had LDL-C levels measured every 4 to 5 years throughout a 25-year period. Seventy-five subjects were identified with persistent HBLP, defined as an LDL-C Ͻ70 mg/dL on at least 2 observations, for a prevalence of 1.9% in this population. Compared with subjects with LDL-C Ն70 mg/dL, subjects with HBLP had significantly lower mean levels of total cholesterol, LDL-C, triglyceride, and apoB; higher levels of high density lipoprotein cholesterol; and a higher prevalence of the E2/E3 genotype: 38.7% versus 10.9% (PϽ0.001). Men with HBLP had a larger mean LDL particle size than did men with an LDL-C Ն70 mg/dL. One individual had a truncated apoB as a cause of HBLP, for a prevalence of 0.03%. Medical causes of HBLP included 2 cases of Crohn's disease, 1 of hemochromatosis, and 1 of hepatitis. Three subjects with HBLP developed coronary heart disease, for an incidence of 4% compared with 5% in those with an LDL-C Ն70 mg/dL (PϭNS). The incidence of cancer was 8% in those with HBLP compared with 4% in those with an LDL-C Ն70 mg/dL (Pϭ0.21). In conclusion, a truncated apoB was a rare cause of HBLP, whereas the E2/E3 genotype was a much more common cause. A large prospective study is needed to evaluate the incidence of cancer and atherosclerosis in subjects with HBLP. (Arterioscler Thromb Vasc Biol. 1998;18:1745-1751.)

show abstract

“…Роль дислипидемии и особенно гиперхолестерине-мии в развитии ИБС достаточно хорошо изучена и убеди-тельно продемонстрирована в многочисленных междуна-родных исследованиях. Сильная положительная взаимо-связь между концентрацией общего холестерина, холесте-рина низкой плотности, триглицеридов при первоначаль-ном скрининге и риском развития ИБС у лиц обоего пола показана в крупнейших проспективных исследованиях, таких как Фремингемское, MRFIT, PROCAM, INTER-HEART, а также в ряде других [30][31][32][33][34][35][36].…”

Section: ключевые слова: ишемическая болезнь сердца цереброваскулярнunclassified

The unity of approaches to preventing coronary heart disease and cerebrovascular diseases

Kim¹,

Bochkareva²,

Варакин³

2015

Profil. med.

View full text Add to dashboard Cite

Serum Cholesterol Level and Mortality Findings for Men Screened in the Multiple Risk Factor Intervention Trial

Cited by 551 publications

References 76 publications

A systematic review and economic evaluation of statins for the prevention of coronary events

A systematic review and economic evaluation of statins for the prevention of coronary events

Frequency of ApoB and ApoE Gene Mutations as Causes of Hypobetalipoproteinemia in the Framingham Offspring Population

The unity of approaches to preventing coronary heart disease and cerebrovascular diseases

Contact Info

Product

Resources

About