Serum Cholesterol Concentrations in Newborn Infants With Gestational Ages of 28–42 Weeks

Ginsburg, B. E.; Zetterström, Rolf

doi:10.1111/j.1651-2227.1980.tb07326.x

Cited by 39 publications

(25 citation statements)

References 14 publications

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“…Several investigators have shown that prenatal and perinatal complications can influence CB lipid levels (12)(13)(14)(15)(16)(17)(18)(19)(20). It is well known that prematurity (gestational age less than 37 wk) is associated with elevated TC and low TG (1 2, 14, 17-19, 2 1) and that TC is elevated in infants of diabetic mothers (19,35,36).…”

Section: Discussionmentioning

confidence: 99%

“…Of the total CB plasmas examined, 154 samples with plasma volume of 2 ml or more were selected for determination of HDL-cholesterol and for evaluation by gradient polyacrylamide gel electrophoresis. Since prematurity and perinatal complications have been shown to be associated with elevated CB lipid levels (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22), emphasis was placed on inclusion of infants with pre-and perinatal complications or lipid levels above 100 mg/dl.…”

Section: Methodsmentioning

confidence: 99%

“…(1 1) and was deficient in (HDL3a)gge, the major peak in adult HDL. Several reports indicate that prematurity and pre-and perinatal complications elevate the cholesterol and TG levels of cord blood (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). However, little is known about the effect of elevated lipid levels on the HDL subclass distribution in the newborn.…”

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High-Density Lipoprotein Subclass Distribution And Human Cord Blood Lipid Levels

1986

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ABSTRACT. The high-density lipoprotein (HDL) subclass distribution was examined by gradient gel electrophoresis (gge) in 154 human cord blood samples, and determinations of triglyceride, total cholesterol, and HDL-cholesterol levels were performed. Three distinct gge patterns were recognizable. The first pattern, termed the normal (gge) pattern, was distinguished by a prominent double peak in the (HDL2,),, region and a pronounced peak in the (HDL3b)gge region. Minor peaks, or shoulders, were also seen in the (HDLZb)gge and (HDL3Jae regions, and a valley was present in the (HDL3,),,, region. This pattern was associated with normal lipid levels for cord blood plasma (mean triglycerides: 30-42 mg/dl; mean total cholesterol 62-85 mg/dl; mean HDL-cholesterol: 34-41 mg/ dl).The second pattern, termed the 2b(gge) pattern, contained a major peak in the ( H D L z~)~~, region rather than the shoulder seen in the normal (gge) pattern, while the (HDL2.)gge, (HDL3b),e, and (HDL3,),, regions were less pronounced. This pattern was associated with elevated total cholesterol and HDL-C levels (means 85-102 and 49-56 mg/dl, respectively). The third pattern, termed the 3b(gge) pattern, was characterized by a paucity of material in the (HDL2,,),, region, a single peak in the (HDLza),, region, and either a relative increase in the (HDL3b),e region, or a simultaneous increase in both (HDLs~),~ and (HDL3e),e. This pattern was associated with elevated triglyceride levels (means 78-88 mg/dl) and decreased HDL-C levels (means 20-30 mg/dl). Only two infants had a simultaneous elevation of triglycerides and total cholesterol and both cases exhibited the 3b(gge) pattern. Our study demonstrates that although the triglyceride and cholesterol levels in the newborn are much lower than those in adults, they are the important factors associated with the HDL subclass distribution. Elevated cholesterol was related to increased particles in the (HDL2b), region while elevated triglyceride levels were associated with a decrease in (HDL2b+2a)gge particles and a concomitant increase in (HDLsb),, particles. (Pediatr Res 20: 487-491, 1986) Abbreviations HDL, high-density lipoproteins TG, triglyceride TC, total cholesterol HDL-C, HDL-cholesterol gge, gradient gel electrophoresis CB, cord blood Received October 7, 1985: accepted January 23, 1986. Address correspondence and requests for reprints to Orsolya Genzel-Boroviczeny, M.D., Donner Laboratory, 1-213, University of California, Berkeley, CA 94720.This work was supported by NIH Program Project Grant HL 18574 from the National Heart, Lung, and Blood Institute of the National Institutes of Health and NIH National Research Service Award Training Grant HL 07279.There is growing evidence that HDL, and in particular the HDL2 subclass, have a protective role in the process of atherogenesis (1-3). In contrast to adults, in whom low density lipoproteins predominate, HDL is the predominant lipoprotein species in human CB (4-10). Davis et al. (4) found that in healthy term infants with lipoprotein levels below 10...

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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High-Density Lipoprotein Subclass Distribution And Human Cord Blood Lipid Levels

1986

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“…In North America every child over the age of 3 years old has some degree of aortic fatty streaks (9). Extensive epidemiological evidence supports the relationship between both genetic and maternal factors such as hypercholesterolemia, diet, mode of delivery, length of pregnancy and pre-eclampsia with the cord blood lipids and lipoprotein profiles (5,(10)(11)(12)(13)(14)(15)(16)(17)(18). Additionally, the fetal life is affected by maternal age (19,20).…”

Section: Introductionmentioning

confidence: 99%

Determination of the Lipid Profile of Cord Blood in Neonates and its Correlation with Maternal Age in Iran

2012

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A B S T R A C TBackground: Cardiovascular diseases (CVDs) are the leading cause of mortality in Iran; with dyslipidemia as an important contributing risk factor. Objectives: To assess the early onset of dyslipidemia, our goal was to determine lipids and lipoproteins levels in cord blood and their correlation with maternal age as a first study in Iran. Patients and Methods: This cross sectional study was done on the cord blood of 243 healthy, full-term newborn infants (114 females and 129 males). The blood was sampled from the umbilical cord immediately after a normal delivery. The serum was tested in order to determine the lipid profile including total cholesterol (TC), triglycerides (TG) and high density lipoprotein-cholesterol (HDL-C). Low density-lipoprotein (LDL-C) was computed by Friedewald equation. Results: A statistically significant negative correlation was observed between cord blood HDL-C and maternal age (r = -0.18, P <0.01). There was no relationship between other lipids and lipoproteins with maternal age. Our findings also showed the TC, TG and LDL-C mean level were significantly more and the mean level of HDL-C was significantly lower than reference value. Additionally, the mean of TC and LDL-C in female neonates were significantly more than the male (P <0.01). Also, there was no correlation between cord blood lipids and lipoproteins with birth weight and maternal body mass index (BMI). Conclusions: In a current study based on increasing maternal age, the HDL-C level in cord blood was decreased which is an independent risk factor for CVDs in adulthood.

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“…[1][2][3] Concentrations of the cord blood lipoprotein subtypes are influenced by fetal malnutrition and prematurity. [4][5][6] High concentrations of triglyceride-rich lipoproteins, and apolipoprotein B in infants with a low gestational age; and increase of Apo c-1 rich in high-density lipoprotein (HDL) with low birth weight are potential risk factors for cardiovascular disease in the future. 7,8 It is known that deviations in maternal hyperlipidemia, such as those caused by hypercholesterolemia, even when temporary and limited to pregnancy, trigger pathogenic events in the fetal aorta and may lead to atherosclerosis later in life.…”

Section: Introductionmentioning

confidence: 99%

Correlation of maternal lipid profile with newborn’s lipid profile

Gora

Dev

Gupta

et al. 2018

Int J Contemp Pediatr

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Background: Atherosclerotic cardiovascular disease (CVD) is a major cause for morbidity and mortality in the adult population. Altered lipid levels are the recognized factors. This process is considered to begin in early life and progress silently over decades. Maternal lipid concentrations may exert an in-utero influence on infant’s lipid profile. The objective of the study was to find out the correlation of maternal lipid profile with newborn’s lipid profile.Methods: This is a hospital based, cross sectional study. After applying inclusion and exclusion criteria, a total of 220 parturients and their respective newborns were enrolled. Out of 220 newborns, 110 were <2.5 kg (group A) and 110 were ≥2.5kg (group B) babies. 2.5 ml of Cord blood sample from each of enrolled newborns was collected from the placental end of the cord just after the delivery. Blood samples from the parturients were collected right after delivery. The concentrations of total cholesterol, triglycerides and HDL-c were determined by an enzymatic colorimetric method and LDL-c was calculated by the Friedewald formula.Results: In present study there was a statistically significant but poor negative correlation between maternal TG and babies’ TG level among low birth weight (˂2.5kg) babies and no other significant correlation was observed between maternal lipid profile and newborn’s lipid profile.Conclusions: Change in maternal lipid profile is not significantly associated with the mean concentrations of total cholesterol, LDL-c, HDL-c and triglycerides in newborns. Hence it shows that neonatal lipogenesis may be independent of maternal lipogenesis.

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Serum Cholesterol Concentrations in Newborn Infants With Gestational Ages of 28–42 Weeks

Cited by 39 publications

References 14 publications

High-Density Lipoprotein Subclass Distribution And Human Cord Blood Lipid Levels

High-Density Lipoprotein Subclass Distribution And Human Cord Blood Lipid Levels

Determination of the Lipid Profile of Cord Blood in Neonates and its Correlation with Maternal Age in Iran

Correlation of maternal lipid profile with newborn’s lipid profile

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