Determination of the Lipid Profile of Cord Blood in Neonates and its Correlation with Maternal Age in Iran

Esfarjani, Shahla Vaziri; Iravani, Elham; Azar, Maryam Razzaghi

doi:10.17795/compreped-6347

Cited by 12 publications

(12 citation statements)

References 35 publications

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“…In this study, the mean value of TG in 33% of females and 35% of males was higher than the 95 th percentile of triglyceride level reported in the Nelson textbook of Pediatrics, which indicates a high frequency of cord blood hypertriglyceridemia in our subjects (34). There are other reports of high cord blood hypertriglyceridemia in Iran (16,17,19,37), yet the level of cord blood TG in our study was higher than other reports from Iran (17,33). High triglyceride level may be due to the relatively high frequency of vitamin D deficiency in Iranian newborns (20,21).…”

Section: Discussioncontrasting

confidence: 85%

“…High triglyceride level may be due to the relatively high frequency of vitamin D deficiency in Iranian newborns (20,21). In our study there were no significant differences between the two sexes regarding the mean value of TC, LDL-C, HDL-C and TG, which is different from the results of some previous studies (17,27,37) and similar to the reports of Ghiasi et al (33). There was no statistically significant association between lipid levels and anthropometric parameters in our study.…”

Section: Discussioncontrasting

confidence: 51%

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Lipid Profile of Cord Blood in Term Newborns

Kazemi

Sadeghzadeh

2014

J Compr Ped

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Background: Hyperlipidemia is an important risk factor for coronary artery disease. Detection of lipid profile in umbilical cord blood of term newborns could identify neonates with a higher risk of coronary artery disease. Objectives: The aim of the present study was to improve the existing information about cord blood lipid profile of Iranian term newborns. Patients and Methods: This cross-sectional study was conducted on healthy term neonates born from healthy mothers between August and October 2009 in Zanjan, Iran. Ten milliliters of cord blood was collected from the placental end of umbilical vein immediately after the cord clamping. Total cholesterol (TC) and triglyceride (TG) were measured by enzymatic GOD-PAP method with Pars Azmoon kits. High-density lipoprotein-cholesterol (HDL-C) was measured after precipitation of Apo lipoproteins with phosphotungstic acid (PTA). Lowdensity lipoprotein-cholesterol (LDL-C) was calculated by Friedewald's formula. Statistical Analysis was performed by the SPSS statistical package version 16.0 for windows. Results: Of the 174 neonates, 97 were female. Vaginal delivery was recorded in 79.8%. There were no significant differences regarding demographic findings between male and female neonates. The mean values of TC, LDL-C, HDL-C and TG were 73.1 ± 26.5, 28.7 ± 11.1, 27.6 ± 10, and 81.4 ± 37.1mg/dL respectively, with no difference between the two sexes. Conclusions: We found a relatively high value of TC and TG in our study. Considering the relationship between high levels of lipids in the neonatal period and coronary artery disease in the adult population, we recommend future cohort studies for this statistical society.

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Section: Discussioncontrasting

confidence: 85%

Section: Discussioncontrasting

confidence: 51%

Lipid Profile of Cord Blood in Term Newborns

Kazemi

Sadeghzadeh

2014

J Compr Ped

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“…9 Shahla Vaziri Esfarjani et al, studied the influence of maternal age on the cord lipid profile and found that there is a statistically significant negative correlation between cord blood HDL-C and maternal age (p <0.01). 10 A study by Juárez IE et al, concluded that there is an association between lipid levels in mothers and their children. 11 However, Murthy et al, in his study noted a significantly high level of TC in the newborn of mothers with high TG levels.…”

Section: Discussionmentioning

confidence: 99%

Association of cord blood and maternal lipid profile

Zohra

Prabhu

Rao

et al. 2020

Int J Contemp Pediatr

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Background: Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity with dyslipidemia as an important contributing risk factor. Objective of the study was to determine whether there is an association between maternal lipid profile and the cord blood lipid profile of their newborns.Methods: This was a hospital-based Cross-sectional study on 60 mothers and their respective newborns (30 term and 30 preterm) conducted in Yenepoya medical college hospital from August to November 2019. Umbilical cord blood samples from the newborns were collected after birth and the mother's venous blood was collected in the fasting state (8hrs of fasting) before delivery. The levels of total cholesterol, triglycerides, HDL, LDL and VLDL were determined in mothers and their newborns by an enzymatic colorimetric method. Data obtained was analyzed by the SSPS software 23.0 version and Pearson's correlation was done.Results: There was a significant correlation between the mean concentration of maternal Triglycerides and the Triglycerides and HDL levels of neonates (p-value <0.05).Conclusions: There was a significant association of cord blood and maternal lipid profile, hence changes in maternal lipid levels might influence the lipid levels in the cord blood of newborns.

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“…This was in concordance with few other studies including Anderson et al and Tsang et al which showed no significant changes in the cord blood lipid profile in terms of gender. 12,13 However, LDL levels were higher in male newborns than female which is in contrast with study by Esfarjani SV et al 14 It is well-recognised fact that low Apo A1 and/or increased Apo B are associated with increased cardiovascular risk. Elevated Apo B levels and raised Atherogenic index (AI) in young adults are linked with cardiovascular disease in later life.…”

Section: Discussionmentioning

confidence: 84%

Comparison of lipoprotein and apolipoprotein levels in cord blood

Aziz

Beigh

Najeeb

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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Background: Hyperlipidemia is the primary risk factor for coronary artery disease and subsequently leading to morbidity and mortality in adulthood. It is a well-known fact that coronary artery disease can initiate in the fetal stage itself. The present study was planned to analyse cord blood lipoproteins and apolipoproteins levels and its association with gender and birth weight.Methods: This cross-sectional study was conducted in the Department of Biochemistry, in collaboration with Department of Gynecology and Obstetrics at SKIMS Medical College and Hospital, Bemina, Srinagar. A total 200 pregnant women who delivered by normal vaginal delivery and caesarean section were included in the study. 10 ml of umbilical cord blood was collected in a plain vial from the placental end within five minutes of delivery and serum lipoprotein and Apo-lipoprotein levels were measured.Results: Out of 200 newborns102 were males and 98 were females. Statistically significant difference was seen in parameters Apo A1, Apo B, Atherogenic index (Apo B/Apo A1) and LDL between the genders rest of the parameters were statistically. Also 32 newborns (16.0%) had <2500, 152 (76.0%) new born had 2500-4000 and 16(8.0%) > 4000 grams birth weight. The mean lipoprotein and Apo-lipoprotein levels in these new born were compared between the groups. The mean serum levels of TC, TG, LDL and HDL were statistically significant (<0.05) between the three groups were as Apo A1, Apo B, Atherogenic index (Apo B/Apo A1) and VLDL was insignificant (>0.05) respectively.Conclusions: CVD being a leading cause of morbidity and mortality in the developing countries, early screening of the at risk babies i.e. low birth weight newborns using cord blood lipoproteins and apolipoproteins levels helps in primordial and primary prevention of diseases.

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Determination of the Lipid Profile of Cord Blood in Neonates and its Correlation with Maternal Age in Iran

Cited by 12 publications

References 35 publications

Lipid Profile of Cord Blood in Term Newborns

Lipid Profile of Cord Blood in Term Newborns

Association of cord blood and maternal lipid profile

Comparison of lipoprotein and apolipoprotein levels in cord blood

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