Serum cholesterol and triglycerides in patients suffering from ischemic heart disease and in healthy subjects

Triglycerides and Cardiovascular Disease

“…Triglyceride has routinely been identified as a "risk factor" in case-control and angiographic studies, even after adjustment for total cholesterol (TC) or LDL-C [23][24][25][26][27][28][29][30][31][32][33][34] and HDL-C. 24,[27][28][29]33,34 In another case-control study, case subjects were 3-fold more likely to exhibit small, dense low-density lipoprotein (LDL) particles, referred to as the "pattern B" phenotype. 35 However, the triglyceride level explained most of the risk of the pattern B phenotype and was a stronger covariate than LDL-C, intermediate-density lipoprotein (IDL) cholesterol, or HDL-C.…”

Epidemiologic Associations Between Hypertriglyceridemia and Coronary Heart Disease

“…Most importantly from an epidemiologic viewpoint, triglyceride does not emerge as an independent risk factor for coronary heart disease in multivariate statistical analyses controlling for other risk factors. However, a critical question remains: Is there 12 1960 Gustafsonet al, 13 1972 Goldstein et al, 14 1973 Lewis et al, 15 1974 Castellietal., 7 1977 Brunner et al, 16 1977 Cramer et al, 17 1966 Cohnetal., 18 1976 Gotto et al, 19 No evidence that triglyceride is an etiologic factor in atherosclerosis, but is not detected as an independent risk factor in these observational epidemiologic studies? The answer may be yes, and there are several lines of evidence to support this conclusion.…”

“…Table 1 summarizes the early case-control studies that considered the association of triglyceride and coronary heart disease. 7,[11][12][13][14][15][16][17][18][19] The 1959 study by Albrink and Man 11 was the first to suggest that errors in triglyceride metabolism could be involved in the development of coronary heart disease. The end points of subsequent studies included myocardial infarction, both myocardial infarction and angina pectoris, and coronary artery disease as assessed by angiography.…”

Secondary Prevention by Raising HDL Cholesterol and Reducing Triglycerides in Patients With Coronary Artery Disease

“…[1][2][3][4] In many prospective studies, triglyceride levels were predictive of CAD in univariate and multivariate analyses controlling for total cholesterol or low-density lipoprotein cholesterol (LDL-C) levels. [5][6][7] Although in some analyses this association did not persist after adjustment for HDL-C, 8 the predictive value of high triglycerides has been confirmed in a meta-analysis. 9 Nevertheless, direct evidence for the clinical benefit of elevating HDL-C or reducing blood triglyceride levels is scarce because the efficacy of lipidmodifying drugs that lower triglyceride levels and raise HDL-C levels had not been directly assessed in large-scale clinical trials in CAD patients.…”