Epidemiologic Associations Between Hypertriglyceridemia and Coronary Heart Disease

Austin, Melissa A.

doi:10.1055/s-2007-1002767

Cited by 37 publications

(5 citation statements)

References 36 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The significant elevation of cholesterol, LDL (the major cholesterol carrying lipoprotein), triglycerides, VLDL (the major triglyceride carrying lipoprotein) and the low levels of HDL and HDL 2 cholesterol, but not HDL 3 cholesterol in young MI survivors, i.e., Kuwaiti males, was in agreement with some of the previously reported data in young males with MI [6,7,14,27,[28][29][30][31]. Conversely, the observed high levels of apo B and low levels of apo A-I and their correlations with other lipids and lipoproteins in MI patient group may reflect the increased production and/or impaired catabolism of VLDL-LDL particles and may suggest a possible metabolic and functional association among them [30,[32][33][34][35][36].…”

Section: Discussionsupporting

confidence: 91%

Plasma Apolipoproteins A-I, A-II, B, C-II, C-III, and E Levels in Young Kuwaiti Male Survivors of Myocardial Infarction

Al-Muhtaseb

Al-Yousuf

1992

Ann Saudi Med

View full text Add to dashboard Cite

Plasma levels of lipid, lipoprotein, and apolipoprotein (APO) A-I, A-II, C-II, C-III, and E were analyzed in 180 young survivors of myocardial infarction (MI) aged 28 to 45 years and in 200 sex-and age-matched normal healthy subjects to assess the importance of apolipoprotein concentrations in comparison with lipoproteins in MI patients. In comparison with control subjects, MI patients showed marked increases in the following parameters: total cholesterol (TC), low density lipoproteins (LDL) cholesterol, triglyceride (TG), very low density (VLDL) triglycerides, and cholesterol, and LDL-TG, apo B, apo C-III and apo E. There were no significant changes in levels of HDL 3 cholesterol, apo A-II and apo C-II in these patients compared with their controls. Levels of high density lipoprotein (HDL), HDL 2 cholesterol, and plasma apo A-I were markedly decreased in the young MI survivors' group when compared with their corresponding controls. Discriminant function analysis demonstrated that the better discriminating lipoproteins and apolipoproteins in MI patients in descending order were HDL 2 cholesterol, apo C-III, apo B, apo A-I, VLDL triglycerides and HDL cholesterol discriminated between patients and controls. Results indicate that measurement of apo C-III, B and A-I beside HDL 2 cholesterol were shown to be of potential use in differentiating normal controls from patients with MI.

show abstract

Section: Discussionsupporting

confidence: 91%

Plasma Apolipoproteins A-I, A-II, B, C-II, C-III, and E Levels in Young Kuwaiti Male Survivors of Myocardial Infarction

Al-Muhtaseb

Al-Yousuf

1992

Ann Saudi Med

View full text Add to dashboard Cite

show abstract

“…Multiple linear regression analysis of leptin adjusted for age small dense LDL particles 26) . High affinities of small dense LDL for arterial proteoglycans, or other cell surface sites, may enhance the trapping of small dense LDL, prompting modification of the vascular wall, which are both processes known tocontribute to the development of atherosclerosis 27) .…”

Section: Table3mentioning

confidence: 99%

Cardiorespiratory Fitness and Metabolic Markers in Healthy Young Adult Men

et al. 2011

View full text Add to dashboard Cite

Abstract.[Purpose] The purpose of this study was to clarify the relationship between cardiorespiratory fitness and metabolic markers, including leptin, in healthy young adults.[Subjects] The subjects were 51 healthy young men (mean age, 21.6 years; range, 18-31 years).[Methods] Ventilatory threshold and maximal oxygen uptake were measured on a cycle ergometer. The metabolic markers, HDL-cholesterol, triglyceride, fasting glucose, fasting insulin and leptin, were also measured, as well as and body composition, body height, body weight, percentage fat mass, waist circumference, and hip circumference. Blood pressure levels were recorded at rest.[Results] Our results show that lower cardiorespiratory fitness was significantly associated with higher storage of fat, lipid markers of developing atherosclerosis, and circulating leptin levels. Higher circulating leptin levels were also associated with metabolic risk markers such as obesity and insulin resistance.[Conclusion] Our results suggest that appropriate cardiorespiratory fitness may improve circulating metabolic markers even in healthy young men. It is therefore important that all persons should have high cardiorespiratory fitness from an early period of life for the effective prevention of cardiovascular disease.

show abstract

“…The ratio of TG to HDL cholesterol was used as a measure of dyslipidemia because the combination of high TG and low HDL cholesterol levels characterizes the dyslipidemia in Syndrome X (14). Furthermore, an elevated ratio of TG to HDL cholesterol has been associated with the presence of atherogenic small dense LDL particles (25).…”

Section: W Chen and Associatesmentioning

confidence: 99%

Age-related patterns of the clustering of cardiovascular risk variables of syndrome X from childhood to young adulthood in a population made up of black and white subjects: the Bogalusa Heart Study.

et al. 2000

View full text Add to dashboard Cite

The age-related patterns of clustering of cardiovascular risk variables of Syndrome X from childhood to adulthood were examined in a community-based sample of black and white children (aged 5-10 years, n = 2,389), adolescents (aged 11-17 years, n = 3,371), and young adults (aged 18-37 years, n = 2,115). In the analysis of clustering, insulin resistance index, BMI, triglycerides/ HDL cholesterol ratio, and mean arterial pressure were used either as categorical variables (age-, race-and sexspecific values >75th percentiles) to calculate risk ratios (observed frequency/expected frequency) or as continuous variables (normal scores based on ranks) to compute intraclass correlations. In the total sample, the risk ratio for clustering of adverse levels of all 4 variables was 9.8 for whites (P < 0.01) versus 7.4 for blacks (P < 0.01); the intraclass correlation was 0.33 for whites (P < 0.001) versus 0.26 for blacks (P < 0.001). Both the risk ratio and intraclass correlation were significantly higher in whites than in blacks in the total sample. The intraclass correlations of the 4 variables were significant (P < 0.001) in all race and age-groups, and they were higher during preadolescence and adulthood than during adolescence. Furthermore, unlike risk ratios, intraclass correlations showed a continuous increase with age during adulthood. When BMI was adjusted, the intraclass correlations involving the other 3 variables were reduced by ~50%, and the age-related pattern was no longer evident. These results suggest that the degree of clustering of risk variables of Syndrome X varies with age from childhood to adulthood and is likely influenced by the age-related changes in obesity and the attendant insulin resistance. Diabetes 49:1042-1048, 2000 D yslipidemia, hypertension, hyperinsulinemia, and obesity have been recognized as potent risk factors for coronary heart disease in adults (1-3). These risk factors have also been found to be associated with early atherosclerotic lesions in youth (4,5). Further, the extent of coronary atherosclerosis in youth increased markedly with the number of multiple risk factors (6). Coexistence of the above cardiovascular risk variables often occurs in both children (7-10) and adults (7,8,(11)(12)(13). Such a condition has been termed Syndrome X (14), deadly quartet (15), insulin resistance syndrome (11,16), and multiple metabolic syndrome (17).Although the clustering of cardiovascular risk factors related to Syndrome X has been found to occur at a very early age (7-10) and persist from childhood into adulthood (8), very little is known about the age-related trend in clustering of risk variables during this period. The Bogalusa Heart Study, a long-term community-based investigation of cardiovascular disease risk factors in black and white children and young adults (18)(19)(20), provided a unique opportunity to examine the age-related trend in clustering of risk variables during this period. The objective of the present study was to determine the age-related patterns in the magnitude of clus...

show abstract

Epidemiologic Associations Between Hypertriglyceridemia and Coronary Heart Disease

Cited by 37 publications

References 36 publications

Plasma Apolipoproteins A-I, A-II, B, C-II, C-III, and E Levels in Young Kuwaiti Male Survivors of Myocardial Infarction

Plasma Apolipoproteins A-I, A-II, B, C-II, C-III, and E Levels in Young Kuwaiti Male Survivors of Myocardial Infarction

Cardiorespiratory Fitness and Metabolic Markers in Healthy Young Adult Men

Age-related patterns of the clustering of cardiovascular risk variables of syndrome X from childhood to young adulthood in a population made up of black and white subjects: the Bogalusa Heart Study.

Contact Info

Product

Resources

About