Serum-Cholesterol and Abo and Rhesus Blood-Groups

Oliver, M.F.; Gumming, R.A.; Geizerová, H; Heady, J. A.

doi:10.1016/s0140-6736(69)90322-5

Cited by 63 publications

(21 citation statements)

References 7 publications

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“…The findings of our study are in accordance with those of 2 previous studies that showed that the age of CAD detection and the age of first MI occurrence were lower in patients with blood group A than in those with non-A blood groups (20,21). The finding of elevated serum TC in subjects having blood group A was also in agreement with the findings of previous reports (22)(23)(24)(25)(26). Unlike the control subjects in our study, the control subjects recruited in most of the previously reported studies were not angiographically examined.…”

Section: Discussionsupporting

confidence: 93%

Association of Blood Group A with Coronary Artery Disease in Young Adults in Taiwan

Lee

Lin

et al. 2012

Intern. Med.

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Objective We aimed to investigate the association between the ABO blood groups and the risk of coronary artery disease (CAD) and myocardial infartion (MI) in a young Taiwanese population. Methods We retrospectively recruited 277 consecutive subjects (men younger than 45 years and women younger than 55 years) who underwent coronary angiography (136 with documented CAD and 129 without CAD) at our center, between 2005 and 2008. Their ABO blood groups were determined using standard agglutination techniques. Results Patients with CAD showed a significantly different blood group distribution (O, 30.1%; A, 39.7%; B, 26.5%; AB, 3.7%) than that shown by the controls (O, 42.6%; A, 24.0%; B, 27.1%; AB, 6.2%; p=0.032). Patients with blood group A had a greater risk of CAD and MI than those with non-A blood groups (OR= 2.08, 95% CI=1.23-3.54; OR=2.21, 95% CI=1.19-4.09, respectively). After adjustment for common cardiovascular risk factors such as age, gender, hypertension, cigarette smoking, diabetes mellitus, body mass index, family history of CAD, and lipid profiles; blood group A remained significantly associated with an increased risk of CAD and MI (OR=2.61, 95% CI 1.11-6.14, p=0.028; OR=3.53, 95% CI=1.21-10.29, p= 0.021, respectively). Conclusion Our findings suggest that blood group A is an independent risk factor for CAD and MI in young people in Taiwan.

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Section: Discussionsupporting

confidence: 93%

Association of Blood Group A with Coronary Artery Disease in Young Adults in Taiwan

Lee

Lin

et al. 2012

Intern. Med.

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“…4 An association of ABO group with total cholesterol (TC) and LDLc levels has also long been recognized 5,6 and has recently been reinforced in genetic studies of variation at the ABO locus. [7][8][9][10][11][12] Specifically, the non-O types, which confer an increased risk of CHD, [1][2][3] are associated with increased TC and LDLc levels.…”

Section: Clinical Perspective On P 48mentioning

confidence: 99%

“…[7][8][9][10][11][12] Specifically, the non-O types, which confer an increased risk of CHD, [1][2][3] are associated with increased TC and LDLc levels. 5,6,12 Furthermore, studies have shown that non-O-type individuals have higher cholesterol absorption rates 12,13 and that the cholesterol absorption rate is positively associated with cardiovascular risk. 12,14 Therefore, it is thought that the effect of ABO on CHD susceptibility is in part mediated by its influence on cholesterol levels.…”

Section: Clinical Perspective On P 48mentioning

confidence: 99%

Analysis of Circulating Cholesterol Levels as a Mediator of an Association Between ABO Blood Group and Coronary Heart Disease

Chen

et al. 2014

Circ Cardiovasc Genet

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“…Another method for the identification of genetic variation is to search for associations between individual risk factors and genetic polymorphisms. In fact, several reports have indicated an association between the ABO blood group polymorphism and total cholesterol for adults of Western European origin [Long man et al, 1969;Mayoet al, 1969;Oliver et al, 1969;Morton, 1976;Garrison et al, 1979;Sing and Orr, 1976], but contrary findings have also been reported. This re lationship has not been found in Asiatic population such as Indians [Srivastava and Sinha.…”

Section: Introductionmentioning

confidence: 97%

ABO Associations with Blood Pressure, Serum Lipids and Lipoproteins, and Anthropometric Measures

et al. 1985

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Discriminant analysis was used to explore multivariate associations with ABO blood types in a biracial sample of 898 Bogalusa youths. Dependent variables included blood pressure (systolic and diastolic), serum lipid and lipoprotein levels (total cholesterol, α-, β-, and pre- β-lipoprotein cholesterol, and triglycerides), and anthropometric variables (height, weight, right arm length, triceps skinfold thickness, and a computed ponderal index). Analyses performed within race showed that several variables including β-lipoprotein cholesterol, systolic blood pressure, and the ponderal index were sufficient to discriminate between individuals possessing the B antigen (B and AB) and those not possessing the B antigen (A and O) in the White subsample. However, height in itself can account for the detected difference, B individuals being taller than non-B individuals by a mean value of 2.4 cm. A concordant, but not significant effect was found in the Black subsample. Further tests support the conclusion that the strongest association is between ABO blood type and height.

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Serum-Cholesterol and Abo and Rhesus Blood-Groups

Cited by 63 publications

References 7 publications

Association of Blood Group A with Coronary Artery Disease in Young Adults in Taiwan

Association of Blood Group A with Coronary Artery Disease in Young Adults in Taiwan

Analysis of Circulating Cholesterol Levels as a Mediator of an Association Between ABO Blood Group and Coronary Heart Disease

ABO Associations with Blood Pressure, Serum Lipids and Lipoproteins, and Anthropometric Measures

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