Analysis of Circulating Cholesterol Levels as a Mediator of an Association Between ABO Blood Group and Coronary Heart Disease

Chen, Yequn; Chen, Chang; Ke, Xiayi; Xiong, Longgen; Shi, Yipeng; Li, Jiafu; Tan, Xuerui; Ye, Shu

doi:10.1161/circgenetics.113.000299

Cited by 72 publications

(67 citation statements)

References 25 publications

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“…In several clinical researches as well as studies investigating the effects of genetic variants [29][30][31], mediation analysis has been used to assess an intermediate variable as a mediator in the pathway between a risk factor and an outcome to estimate the extent to which the effect of the risk factor occurs through the mediator. In the current study, we performed this analysis and specifically found that both sdLDL-C and large HDL-C were partly mediated this relationship, however, only 8.7-10.5% effect size has been mediated, which may suggest that SUA probably plays an important role in the development of CAD by itself or through other pathways.…”

Section: Tablementioning

confidence: 99%

Lipoprotein subfractions partly mediate the association between serum uric acid and coronary artery disease

Zhang

et al. 2015

Clinica Chimica Acta

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Section: Tablementioning

confidence: 99%

Lipoprotein subfractions partly mediate the association between serum uric acid and coronary artery disease

Zhang

et al. 2015

Clinica Chimica Acta

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“…As possible links between ABO blood groups and CAD pathogenesis, previous studies have emphasized the increased prothrombotic state, higher prevalence of traditional cardiovascular risk factors, and higher level of systemic inflammatory response revealed in patients with different ABO blood groups [3][4][5]. Recently, genome-wide association studies (GWAS) have revealed significant associations of genetic variants in the ABO blood group region with levels of various inflammatory markers, including soluble levels of E-selectin (sE-selectin), intercellular adhesive molecule 1 (ICAM1), and P-selectin (sP-selectin) [6].…”

mentioning

confidence: 99%

High-sensitivity C-reactive protein mediates in part the impact of ABO blood group on coronary artery disease

Gong¹,

Li²,

Luo³

et al. 2014

International Journal of Cardiology

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“…[16][17][18][19][20][21][22][23][24][25] In above studies, it was found that the prevalence of disease in male was more than female. Also, the sixth and seventh decades of life are the most prevalent age of the disease occurrence, which was confirmed by the above studies.…”

Section: Discussionmentioning

confidence: 99%

Study frequency of ABO and RH in patients with acute coronary syndrome referred to Ardabil city hospital

2018

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Background: Regarding the high prevalence, the increasing trend of acute coronary syndrome (ACS), the importance of etiological studies of diseases and the existence of some reports on the role of blood groups in the development of diseases, including IHD, in order to study the blood groups in patients with acute coronary syndrome and other factors, this research was conducted in Ardabil.Methods: This is a descriptive study that was carried out from March 2016 to May 2017 in a Hospital of Ardabil on 500 patients selected randomly from patients admitted to cardiac care unit of Hospital. The criteria for entering the study were: All subjects over the age of 30 and both sexes were males and females who had myocardial infarction (MI), unstable angina (UA) based on history, examination, serial electrocardiography and measurement cardiac enzymes are given by a specialist physician and they are willing to participate in the study. Then, in the checklist for each patient, the blood type ABO and RH, the age, sex, and risk factors of the disease such as hypertension, diabetes, obesity, consumption smoking, high blood lipids, and family history of premature stenosis were extracted from the patient records and then analyzes by statistical methods in SPSS.19. Results: Of all patients, 60.2% were male and the mean age was 62.28 years. Hypertension with 61.6%, smoking with 37.4%, and hyperlipidemia with 23.4% were the most common risk factors among patients. The blood groups A and A+ were the most common type of blood type, but due to the higher prevalence of A blood group in healthy individuals living in Ardabil, there was no significant relation between ACS and blood groups.Conclusions: Results showed that blood groups did not show a meaningful relationship with the incidence of ACS and did not find any association between severity of this syndrome and blood groups.

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Analysis of Circulating Cholesterol Levels as a Mediator of an Association Between ABO Blood Group and Coronary Heart Disease

Cited by 72 publications

References 25 publications

Lipoprotein subfractions partly mediate the association between serum uric acid and coronary artery disease

Lipoprotein subfractions partly mediate the association between serum uric acid and coronary artery disease

High-sensitivity C-reactive protein mediates in part the impact of ABO blood group on coronary artery disease

Study frequency of ABO and RH in patients with acute coronary syndrome referred to Ardabil city hospital

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