Serum-Cholesterol and ABO and Rhesus Blood Groups

Oliver, M.F.; Geizerová, H; Cumming, R. A.; Heady, J. A.

doi:10.1097/00043764-197006000-00013

Cited by 3 publications

(3 citation statements)

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“…Past epidemiological studies, some dating as far back as 50 years ago, have suggested evidence for ABO association with circulating levels of cholesterol, with non-O groups appearing to have higher levels [ 47 , 62 – 65 ]. For example, in 1976, Garrison et al published an epidemiological analysis in the Framingham Heart Study showing consistent elevations of serum cholesterol levels in non-O blood groups when compared to the O blood group [ 47 ].…”

Section: Associations Of the Abo Locus With Markers Of Endothelialmentioning

confidence: 99%

ABO Blood Groups and Cardiovascular Diseases

Zhang

Mooney

Reilly

2012

International Journal of Vascular Medicine

108

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ABO blood groups have been associated with various disease phenotypes, particularly cardiovascular diseases. Cardiovascular diseases are the most common causes of death in developed countries and their prevalence rate is rapidly growing in developing countries. There have been substantial historical associations between non-O blood group status and an increase in some cardiovascular disorders. Recent GWASs have identified ABO as a locus for thrombosis, myocardial infarction, and multiple cardiovascular risk biomarkers, refocusing attention on mechanisms and potential for clinical advances. As we highlight in this paper, more recent work is beginning to probe the molecular basis of the disease associations observed in these observational studies. Advances in our understanding of the physiologic importance of various endothelial and platelet-derived circulating glycoproteins are elucidating the mechanisms through which the ABO blood group may determine overall cardiovascular disease risk. The role of blood group antigens in the pathogenesis of various cardiovascular disorders remains a fascinating subject with potential to lead to novel therapeutics and prognostics and to reduce the global burden of cardiovascular diseases.

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Section: Associations Of the Abo Locus With Markers Of Endothelialmentioning

confidence: 99%

ABO Blood Groups and Cardiovascular Diseases

Zhang

Mooney

Reilly

2012

International Journal of Vascular Medicine

108

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“…This suggested greater susceptibility of phenotype A individuals to myocardial infarction, atherosclerotic peripheral vascular occlusive disease, and other forms of CVD than non-A individuals [Kingsbury, 197 1;Weiss, 1972;Allan, 1973;Morris and Bouhoutsos, 1973;Garrison et al, 1976;Cronenwett et al, 1983;Platt et al, 1985;Hrby et al, 19891. Numerous reports of association between ABO phenotypes and total serum cholesterol (TC), one of the recognized major risk factors of CVD, have also appeared [Hames and Greenberg, 1961;Srivastava and Sinha, 1966;Banerjee and Saha, 1969;Oliver et al, 1969;Langman et al, 1969;Medalie et al, 1970;Hagerup et al, 1972;Wakely et al, 1973;Sing and Orr, 1976;Fox et al, 1981;Borecki et al, 1985;George et al, 19871. Higher mean level of TC observed in phenotype A has generated considerable interest on the role of the ABO locus as a factor influencing CVD susceptibility, either directly or indirectly through its effects on the CVD risk factor.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal study of the association between ABO phenotype and total serum cholesterol level in a Japanese cohort

Wong

Kodama

Sasaki

et al. 1992

Genetic Epidemiology

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The relationship between ABO blood phenotype and total serum cholesterol (TC) level was examined in a Japanese population to determine whether an elevated TC level is associated with phenotype A, as has been demonstrated in many West European populations. Such studies in nonwhite populations are scarce, and findings generally failed to demonstrate the relationship. Inconsistent results from cross-sectional studies of various racial groups with widely varying ages raised an age effect as a possible explanatory factor. It was also suggested that the ABO-TC association may not be apparent in populations with low fat intake or low mean cholesterol level. These hypotheses are addressed by examining long-term TC data collected serially from the unexposed controls of the atomic bomb survivors in Hiroshima and Nagasaki who were participants of the Adult Health Study program at the Atomic Bomb Casualty Commission-Radiation Effects Research Foundation between 1958 and 1986. The statistical method of growth curve analysis, through the mixed effect model of Laird and Ware [1982], was used to model age-dependent changes in cholesterol levels within individuals. The effects of the ABO polymorphism in modifying the resultant growth curve are examined. We demonstrate that TC levels are elevated on average by about 4 mg/dl in phenotype A compared to non-A in the Japanese (P < 0.00001), and that this relationship is maintained from early to late adulthood, independent of sex, body mass index, cohort status, or city of residence. Thus, phenotype A individuals may be more predisposed to cardiovascular disease through one of its major risk factors. This is the first study of the ABO-cholesterol association in the Japanese, and the first based on a cohort with longitudinally collected TC data.

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“…Some evidence to support this view comes from the finding of a relationship between ABO blood group, secretor status, and the level of serum cholesterol (Mayo et al 1969, Langrnan et a]. 1969, Oliver et al 1969. Although serum cholesterol is predominantly derived from synthesis in the liver, it is also influenced by absorption of fat through the small intestinal cell.…”

Section: Discussionmentioning

confidence: 99%

Serum intestinal alkaline phosphatase, ABO blood group, secretor status, and lipaemia

1971

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In 70 apparently healthy volunteers serum intestinal alkaline phosphatase activity was unrelated to both the fasting serum triglyceride concentration and the degree of rise of serum triglyceride level after a standard fatty meal. In addition no association was found between ABO blood group, secretor status, and the serum triglyceride concentration after a fatty meal. These findings suggest that the presence of intestinal alkaline phosphatase activity in serum, which is known to be related to ABO blood group, secretor status, and, the eating of fatty meals, is unrelated to the amount of fat absorbed by the intestinal cells.

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Serum-Cholesterol and ABO and Rhesus Blood Groups

Cited by 3 publications

References 0 publications

ABO Blood Groups and Cardiovascular Diseases

ABO Blood Groups and Cardiovascular Diseases

Longitudinal study of the association between ABO phenotype and total serum cholesterol level in a Japanese cohort

Serum intestinal alkaline phosphatase, ABO blood group, secretor status, and lipaemia

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