ABO Blood Groups and Cardiovascular Diseases

Zhang, Hanrui; Mooney, Ciaran James; Reilly, Muredach P.

doi:10.1155/2012/641917

Cited by 88 publications

(122 citation statements)

References 81 publications

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“…Although several studies have been published showing the association between the inheritance of blood groups (ABO and Rh antigens) and cardiovascular diseases [8][9][10], coronary artery disease [7], ischemic heart disease (IHD) [11], however results have not been consistent. According to one study as compared to the other blood groups A blood group subjects had significantly high risk of IHD [11], while another study suggests AB blood groups reduce the risks of CHD while O blood groups raise the risks of CHD due to lower HDL-c levels [10].…”

Section: Introductionmentioning

confidence: 99%

Frequency of expression and the distribution of ABO and Rh, Blood group antigens in the myocardial infarction (MI) male Patients of the Hail region in Saudi Arabia

Farshori¹,

Alrashdan²,

Alshammari³

et al. 2017

J Integr Cardiol

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Cases of adult obesity have been rising in every age group and gender of the Saudi population. If this trend continues it can lead to drastically high incidences of diabetes and the coronary heart disease (CHD). In a recent 2014 world health survey by the WHO, Saudi Arabia was ranked 27 th in the world in CHD related deaths. Additionally in Saudi Arabia CHD was the leading cause of death in 2014. Therefore, in this study we decided to look at the possible correlation between the inheritance of blood group antigens and the high incidences of myocardial infarction (MI) among the adult male patients. Results of our study show that in the randomly selected male control group 20.7% were A + and 3.35% were A -while 14.3% were found to be B + and 3.95% were B -. AB blood group was the least prevalent blood group among the control population. Only 8.2% were found to be AB + and 2.43% were AB -. As previously reported by us and others O + blood group was the most prevalent blood group among the control population at 38.3% while only 8.5% were found to be O -. In contrast when we analyzed the blood group distribution among the 111 MI male patients our results showed a statistically significant reduction in the combined Rh -male MI patients as compared to the Rh -individuals in the control group. Additionally we found a significantly high prevalence of A + blood group (30.6%) among the MI patients as compared to the control population. Our results also showed a small but not a significant increase in B + and O + blood groups in MI patients as compared to the controls. Finally our results show statistically significant reduction in O -MI patients as compared to the control population. In conclusion A + individuals show statistically high incidences of MI and O -individuals show statistically low incidences of MI in male patients. Our results also show a statistically significant reduction in the Rh -MI patients as compared to the control group. Significance of this reduction is not clear at this time.

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Section: Introductionmentioning

confidence: 99%

Frequency of expression and the distribution of ABO and Rh, Blood group antigens in the myocardial infarction (MI) male Patients of the Hail region in Saudi Arabia

Farshori¹,

Alrashdan²,

Alshammari³

et al. 2017

J Integr Cardiol

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“…In particular, the geographic clines of allele distributions could be readily explained by human migrations. Furthermore, selection pressures conferred by pathogen-driven blood group antigen changes could be one of the factors responsible for the current distribution of blood types (Storry and Olsson, 2009;Zhang et al, 2012). Data regarding blood group distribution is useful in medicine, such as for blood transfusions and organ transplantation.…”

Section: Discussionmentioning

confidence: 99%

“…However, the underlying cellular and physiological mechanisms explaining these associations await further research (Zhang et al, 2012;Liumbruno and Franchini, 2013). Even though these studies establish the association of blood group types with certain diseases/ morbidities, the countrywide or global patterns of association have not been emphasized.…”

Section: Discussionmentioning

confidence: 99%

Distribution and clinal trends of the ABO and Rh genes in select Middle Eastern countries

AlSuhaibani¹,

Kizilbash²,

Afshan³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. An understanding of the ABO and Rh blood group systems is important for blood transfusions and is also pertinent due to their potential association with certain morbidities and susceptibilities to infections. To investigate the diversity and differentiation of the ABO and Rh loci in Middle Eastern populations, data from twelve representative Middle Eastern populations were analyzed. Six populations were in conformity with Hardy-Weinberg equilibrium at the ABO locus. The pooled heterozygosity at both loci was calculated to be highest in the sample from Jordan and lowest in Bahrain. Heterogeneity was pronounced in the Northern compared to the Southern Middle Eastern populations. Overall, the absolute gene diversity was 0.0046 and gene differentiation was calculated to be 0.0100. Genetic diversity of the studied loci across all populations (H T ) was estimated to be 0.4594, while the diversity within the populations (H S ) was 0.4548. Nei's genetic distance analyses revealed highest affinities between the populations of Kuwait and Qatar, Oman and Yemen, and between Qatar and the United Arab Emirates. These results were displayed through a UGPMA dendrogram and principal component analyses, which established clustering of certain populations. Clinal trends of the allelic systems were observed by generating contour maps that allow a detailed appreciation of the distributions of alleles across the geography of the Arabian Peninsula and the Middle East. Taken together, these analyses are helpful in understanding the differentiation of blood group loci and for designing prospective studies for establishing the associations of these loci with health variables in the populations studied.

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“…The term histo-blood group ABO is often used to reflect the wide distribution of ABO antigens. Recent evidence suggest that the ABO system could extend its clinical importance beyond immunohematology, transfusion and transplantation medicine, thus playing a role in the pathogenesis of cardiovascular, neoplastic and several other human disorders [7][8][9][10]. However, despite the fact that ABO antigens have been known for more than a century, their biological significance remains largely elusive.…”

Section: Introductionmentioning

confidence: 99%