Distribution and clinal trends of the ABO and Rh genes in select Middle Eastern countries

AlSuhaibani, Entissar S.; Kizilbash, Nadeem; Afshan, Kiran; Malik, Sajid

doi:10.4238/2015.september.9.12

Cited by 5 publications

(9 citation statements)

References 24 publications

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“…The study exemplified that D variants cannot reliably be discriminated with serologic methods (Table S1) [46][47][48] using samples from the Arab population, which has been characterized by serology and molecular techniques before (see supporting information). [49][50][51][52][53] No novel RHD allele was found in our study among 67 donors with the serologic weak D phenotype. We conclude that the molecular description of RHD alleles may have become rather complete, even for complex and variable alleles, such as represented by the RHD alleles constituting the weak D Type 4 cluster.…”

Section: Discussionmentioning

confidence: 88%

“…No precautions to detect DVII have ever been mandated, although D– transfusions would be recommended in any patient, especially women of childbearing age, known to express DVII, as carriers of this partial D can make anti‐D. The study exemplified that D variants cannot reliably be discriminated with serologic methods (Table S1) using samples from the Arab population, which has been characterized by serology and molecular techniques before (see supporting information) …”

Section: Discussionmentioning

confidence: 99%

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Transfusion strategy for weak D Type 4.0 based on RHD alleles and RH haplotypes in Tunisia

et al. 2017

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Background With more than 460 RHD alleles, this gene is the most complex and polymorphic among all blood group systems. The Tunisian population has the largest known prevalence of weak D type 4.0 alleles, occurring in 1 of 105 RH haplotypes. We aimed to establish a rationale for the transfusion strategy of weak D type 4.0 in Tunisia. Study design and methods Donors were randomly screened for the serological weak D phenotype. The RHD coding sequence and parts of the introns were sequenced. To establish the RH haplotype, the RHCE gene was tested for characteristic single nucleotide positions. Results We determined all RHD alleles and the RH haplotypes coding for the serologic weak D phenotype among 13,431 Tunisian donations. A serologic weak D phenotype was found in 67 individuals (0.50%). Among them, 60 carried a weak D type 4 allele: 53 weak D type 4.0, 6 weak D type 4.2.2 (DAR), and 1 weak D type 4.1. Another 4 donors had 1 variant allele each: DVII, weak D type 1, weak D type 3, and weak D type 100, while 3 donors showed a normal RHD sequence. The weak D type 4.0 was most often linked to RHCE*ceVS.04.01, weak D type 4.2.2 to RHCE*ceAR, and weak D type 4.1 to RHCE*ceVS.02, while the other RHD alleles were linked to one of the common RHCE alleles. Conclusions Among the weak D phenotypes in Tunisia, no novel RHD allele was found and almost 90% were caused by alleles of the weak D type 4 cluster, of which 88% represented the weak D type 4.0 allele. Based on established RH haplotypes for variant RHD and RHCE alleles and the lack of adverse clinical reports, we recommend D positive transfusions for patients with weak D type 4.0 in Tunisia.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Transfusion strategy for weak D Type 4.0 based on RHD alleles and RH haplotypes in Tunisia

et al. 2017

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“…At the same study (10), in the North-Eastern part of the Arabian Peninsula, blood group B was the most prevalent blood type however, phenotype B distribution was much less in the southern region of the Arabian Peninsula. On the other hand, high frequency of blood group O was noticeable in the South-Western of the Arabian Peninsula which is in sort of agreement with our ndings.…”

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confidence: 80%

“…On the other hand, high frequency of blood group O was noticeable in the South-Western of the Arabian Peninsula which is in sort of agreement with our ndings. Nevertheless, O blood group has shown much less frequency in the Northeastern part of the region of interest (10). Additionally, Rh-positive was concentrated in the Domah region of Saudi Arabia and more widespread in the southern part of the Arabian Peninsula.…”

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confidence: 99%

Distribution of ABO and Rh types in North of Asir region in Saudi Arabia

Belali

Alanazi

Abomughaid

et al. 2021

Preprint

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Background and Objectives.This study was conducted to form a better understanding of the distribution of ABO and Rh types among the population of the north of Asir region in Saudi Arabia and compare the findings to similar studies that were carried out in other parts of the kingdom and the Middle East. Understanding the frequency of different blood types in different populations is imperative. Blood types are essential not only for transfusion therapy but also for the prediction of the outcome of different diseases. The study aims to establish an understanding of the blood group frequency among the residents of the north of Asir region, Saudi Arabia. Additionally, this study was conducted to compare the blood group frequency in the region to that in different parts of the Arabian Peninsula.Subjects and Methods This study was done throughout 1year from January 1, 2020, to December 31, 2020, using samples from 4142 voluntary subjects at the blood bank of King Abdullah hospital, Bisha. Commercially provided ABO and Rh antibodies were used for the standard blood grouping procedure. Results:Our findings have shown that O is the most prominent ABO blood group while AB was the least frequent. The frequency of A blood type was the second high followed by B blood group while positive Rh factor was more common than the negative. A Comparison of our findings to other studies from Saudi Arabia and nations in the Middle East was also discussed.Conclusion:O+ >A+ >B+ > O->AB+> A->B- > AB- is the order of blood groups frequency in our study for males, while in females the order was almost the same except for the last three blood types was as following: >A->B->AB+. AB- on the other hand, was completely absent in female donors. There are some similarities and differences between our findings and that of other studies from the kingdom and other countries. Knowing and understanding the distribution of ABO and Rh types is essential for creating better policies for transfusion interventions and blood banks managements.

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“…ABO and Rh blood serotypes distributions exhibit variations based on population, time, and region (Liu et al, 2017;AlSuhaibani et al, 2015). In Jordan, A phenotype has the highest percentage while the AB phenotype has the lowest percentage (Hanania et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Da Vinci’s Vitruvian Man, Golden Ratio and Anthropometrics

Alzyoud

Jacoub

Omoush

et al. 2022

Ital J Anat Embryol

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Objectives: Divine golden ratio (Phi = 1.618) observed in several human body parts such as, heart, dentition and upper limb tends to present homeostasis in anatomy and physiology. This cross sectional survey study investigates the relationship of golden ratio with BMI, GPA, gender and blood serotypes in Jordan. Methods: Demographic features including GPA, body weight, lengths of some body parts and ABO/Rh blood groups were measured for 380 undergraduate students of matched age (19.14±0.76) and matched sex ratio. Navel-Foot/Height, Forearm-Hand/Armpit-hand and BMI were calculated. Golden ratio fitness was calculated based on phi and standard deviation of collected data. Results showed significant gender differences in the means for all body lengths measured, GPA, BMI, and calculated ratios. Golden ratio fitted bodies students were 40.5% (Females > males). The overall prevalence of overweight and obesity was 15% (females < males), while 80% (females > males) have normal weight. Among the overweight and obese students 77.2% (44/57, females less than males) lies outside the golden ratio. The overall prevalence of GPA grades above good were 51.3% (females > males) and among them 47.7% (93/195, females > males) fit golden ratio while 67.2% of the good or below GPA grades (121/180, females < males) did not fit golden ratio. No significant difference between ABO-Rh system related to gender or golden ratio fitness. Statistically, a significant association was found between golden ratio and the three parameters BMI, GPA and gender. Conclusions: Students who are golden ratio fitted bodies were more likely to have better BMI and GPA especially females.

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Distribution and clinal trends of the ABO and Rh genes in select Middle Eastern countries

Cited by 5 publications

References 24 publications

Transfusion strategy for weak D Type 4.0 based on RHD alleles and RH haplotypes in Tunisia

Transfusion strategy for weak D Type 4.0 based on RHD alleles and RH haplotypes in Tunisia

Distribution of ABO and Rh types in North of Asir region in Saudi Arabia

Da Vinci’s Vitruvian Man, Golden Ratio and Anthropometrics

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