Serum cholecystokinin concentrations in dogs with naturally acquired pituitary-dependent hyperadrenocorticism

Noh, S. J.; Kim, Hye Sun; Chang, Jinhwa; Kang, Ji Houn; Chang, Dongwoo; Yang, Mhan Pyo

doi:10.2460/ajvr.77.10.1101

Cited by 4 publications

(7 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The significance of a reduction in CCK is important due to its role in gall bladder motility within the BT breed, although it is possibly relevant in other breeds presenting with GBM, despite non-BT not having a significant reduction in CCK in our study. Previous work has identified hyperadrenocorticism as an associative factor in GBM cases (Kim et al 2017), and dogs with hyperadrenocorticism have been shown to have a significant reduction in both CCK and leptin levels (Cho et al 2014, Noh et al 2016. Therefore, the finding of decreased CCK in dogs within this study and the previous identification of reduced CCK (and leptin) in dogs with hyperadrenocorticism suggest the cause of GBM in dogs with hyperadrenocorticism could also relate to gall bladder hypomotility.…”

Section: Discussionsupporting

confidence: 64%

“…Additionally we ran CCK on these samples, without a known history of fat content of the food or exact timing of feeding, however all ELISAs were run on samples which were starved for a minimum of 8 hours. A previous study showed dogs with GBM had significantly higher pre-prandial CCK than control dogs (Noh et al 2016), and in humans lower basal CCK has been noted in patients with coeliac disease compared to controls (Thompson et al 1982). Therefore it seemed appropriate to use pre-prandial, basal samples in these dogs, and these results were deemed to be accurate for CCK measurement.…”

Section: Discussionmentioning

confidence: 99%

“…2014, Noh et al . 2016). Therefore, the finding of decreased CCK in dogs within this study and the previous identification of reduced CCK (and leptin) in dogs with hyperadrenocorticism suggest the cause of GBM in dogs with hyperadrenocorticism could also relate to gall bladder hypomotility.…”

Section: Discussionmentioning

confidence: 99%

“…2015, CCK: Noh et al . 2016). All serum samples were stored at −80°C until they were assayed in duplicate, alongside controls and standards, and their average value reported for analysis.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Serological markers of gluten sensitivity in Border terriers with gall bladder mucocoeles

Barker

Tivers

Kathrani

et al. 2020

J of Small Animal Practice

View full text Add to dashboard Cite

To evaluate serological markers of gluten sensitivity in conjunction with cholecystokinin measurement in Border terriers with gall bladder mucocoeles. Materials and MethOds: Medical records from two referral hospitals were obtained between 2011 and 2019 to identify Border terriers with gall bladder mucocoeles, non-Border terriers with gall bladder mucocoeles and control Border terriers with non-biliary diseases. Enzyme-linked immunosorbent assays were performed on stored fasted serum samples for anti-gliadin IgG, anti-canine transglutaminase-2-IgA autoantibodies and cholecystokinin. Statistical analysis was performed using the Kruskall-Wallis test to identify differences between the groups. results: Fifteen Border terriers with gall bladder mucocoeles, 17 non-Border terriers with gall bladder mucocoeles and 14 control Border terriers with non-biliary diseases were recruited. Median transglutaminase-2-IgA autoantibodies in Border terriers with gall bladder mucocoeles was 0.73 (range: 0.18 to 1.67), which was significantly greater than in control Border terriers at 0.41 (0.07 to 1.14). Median cholecystokinin concentration in Border terriers with gall bladder mucocoeles was 13 pg/mL (6 to 45 pg/mL), which was significantly lower than in control Border terriers at 103 pg/mL (9 to 397 pg/mL). There was no difference in the anti-gliadin IgG between these groups. There was no difference observed in the non-Border terriers with gall bladder mucocoeles with either of the other groups. clinical significance: Reduced cholecystokinin and increased transglutaminase-2-IgA autoantibodies was detected in Border terriers with gall bladder mucocoeles; which is in part homologous to gall bladder disease identified in human coeliac disease. The results suggest an immunological disease with impaired cholecystokinin release may be affecting gall bladder motility and possibly contributing to mucocoele formation in Border terriers.

show abstract

Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Serological markers of gluten sensitivity in Border terriers with gall bladder mucocoeles

Barker

Tivers

Kathrani

et al. 2020

J of Small Animal Practice

View full text Add to dashboard Cite

show abstract

“…Serum or plasma cortisol concentrations in blood samples obtained before and after adrenocorticotropic hormone (ACTH) administration are commonly used for confirming a diagnosis of hyperadrenocorticism (HAC) or hypoadrenocorticism in dogs . Results of the ACTH stimulation test (ACTHst) are also used to aid in determining optimal dose and frequency of medications used in the short and long‐term management of dogs with HAC .…”

mentioning

confidence: 99%

Effect of Intravenous or Perivascular Injection of Synthetic Adrenocorticotropic Hormone on Stimulation Test Results in Dogs

Johnson

Kass

Cohen

et al. 2017

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundStandard protocols for adrenocorticotropic hormone (ACTH) stimulation testing (ACTHst) often involve intravenous (IV) injection of corticotropin. ACTH might be unintentionally injected into the perivascular (PV) space.ObjectiveTo compare stimulation test results after IV and PV injections of ACTH.AnimalsTwenty privately owned dogs were studied: 10 healthy and 10 with trilostane‐treated naturally occurring hyperadrenocorticism (HAC).MethodsProspective study. Each of 20 dogs underwent 2 ACTHst not <4 nor more than 14 days apart. Five healthy and 5 HAC dogs had an IV ACTHst first and PV second; 5 healthy and 5 HAC dogs had a PV ACTHst first and IV second. Blood samples for measurement of serum cortisol concentration were collected before and 1 hour after ACTH administration.ResultsNo significant difference in results was demonstrated when comparing serum cortisol concentrations after IV and PV ACTH administration in all 20 dogs (median μg/dL; interval μg/dL: 8.2; 1.4–17.4 versus 7.8; 0.9–16.9; P = .23). No significant difference in results was demonstrated when comparing serum cortisol concentrations after IV and PV ACTH administration in the 10 healthy dogs (median μg/dL; interval μg/dL: 10.9; 7.3–17.4 versus 10.6; 7.1–16.9; P = .54) or in the 10 HAC dogs (median μg/dL; interval μg/dL: 6.3; 1.4–8.6 versus 5.2; 0.9–8.7; P = .061).Conclusions and Clinical ImportancePerivascular administration of ACTH does not significantly alter stimulation test results in healthy dogs or in dogs with HAC undergoing therapy with trilostane.

show abstract

Impact of fatty acid composition on markers of exocrine pancreatic stimulation in dogs

Zhang,

Kirk,

Tolbert

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Chronic pancreatitis in dogs is typically managed with a low-fat diet. Human research suggests that consumption of medium-chain triglycerides (MCT) may lessen pancreatic enzyme release compared to consumption of long-chain fatty acids (LCFA). Twelve healthy adult colony dogs were fed a meal of cod and rice with either 3% metabolizable energy (ME) fat (control), high MCT (25% ME MCT oil, 25% ME butter), high saturated LCFA (50% ME butter), or high unsaturated LCFA (50% ME canola oil) in a 4-period by 4-treatment crossover design. Serum concentrations of canine pancreatic lipase immunoreactivity, gastrin, cholesterol, triglycerides, and serum activities of amylase and DGGR lipase (1,2-o-dilauryl-rac-glycero-3-glutaric acid-(69-methylresorufin) ester lipase) were measured at times 0 (fasted), 30, 120 and 180 minutes post-prandially. Following a 3-or 4-day wash-out period, each dog was assigned a new diet and the process was repeated for all treatments. Data were analyzed as a repeated-measures mixed model ANOVA. Post-hoc pairwise comparisons were run using Tukey-Kramer adjusted p-values. Shapiro-Wilk tests were used to evaluate residual normality. All statistical assumptions were sufficiently met. Statistical significance was defined as P<0.05. Of the markers tested, only serum triglyceride concentrations were affected by treatment, with consumption of high MCT resulting in lower triglycerides than both LCFA groups at times 120 and 180 minutes (P<0.0001). As expected, the high MCT group had higher triglycerides compared to the control group (P<0.0001). The type of dietary fat consumed had little acute impact on most markers of exocrine pancreatic stimulation in healthy dogs.

show abstract

Serum cholecystokinin concentrations in dogs with naturally acquired pituitary-dependent hyperadrenocorticism

Cited by 4 publications

References 35 publications

Serological markers of gluten sensitivity in Border terriers with gall bladder mucocoeles

Serological markers of gluten sensitivity in Border terriers with gall bladder mucocoeles

Effect of Intravenous or Perivascular Injection of Synthetic Adrenocorticotropic Hormone on Stimulation Test Results in Dogs

Impact of fatty acid composition on markers of exocrine pancreatic stimulation in dogs

Contact Info

Product

Resources

About