Serum Chemerin Levels are Associated with Visceral Adiposity, Independent of Waist Circumference, in Newly Diagnosed Type 2 Diabetic Subjects

Cheon, Dae Young; Kang, Jun Goo; Lee, Seong Jin; Ihm, Sung Hee; Lee, Mi Kyung; Choi, Moon Gi; Yoo, Hyung Joon; Kim, Chul Sik

doi:10.3349/ymj.2017.58.2.319

Cited by 28 publications

(39 citation statements)

References 31 publications

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“…(3,19,20) After the first laboratory analysis, some blood samples were insufficient to reveal the values of each variable that composed MC, requiring a new sample. However, due to the refusal of some participants to collect the blood material for the second time, in those cases where the first collection was not sufficient, some missing data may be observed in the results.…”

Section: Methodsmentioning

confidence: 99%

Controle metabólico e adesão medicamentosa em pessoas com diabetes mellitus

et al. 2017

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Objective: To relate adherence to oral antidiabetics and metabolic control of people with Type 2 Diabetes mellitus. Methods: An analytical study conducted with 201 participants, of both sexes, aged over 18 years with diagnosis of type 2 diabetes mellitus, cared for in the basic health units. Sociodemographic, anthropometric and clinical variables related to medication adherence and metabolic control were analyzed. Morisky's test was used to evaluate adherence to medication therapy. Results: Only 23.9% of the participants were considered adherents to medication treatment, showing better levels of glycated hemoglobin (p = 0.048), fasting glycemia (p <0.001), and total cholesterol (p = 0.028). Conclusion: A relationship between adherence to oral antidiabetics and some variables of metabolic control was identified, such as glycated hemoglobin, fasting glycemia and total cholesterol. Medication adherence should be increasingly encouraged among people with Diabetes mellitus. ResumoObjetivo: Relacionar a adesão aos antidiabéticos orais e o controle metabólico de pessoas com Diabetes mellitus tipo 2. Métodos: Estudo analítico, realizado com 201 participantes, de ambos os sexos, com idade acima dos 18 anos e diagnóstico de Diabetes mellitus tipo 2, acompanhados em unidades básicas de saúde. Foram analisadas variáveis sociodemográficas, antropométricas, clínicas, relacionadas à adesão medicamentosa e ao controle metabólico. Para verificar a adesão à terapêutica medicamentosa utilizou-se o Teste de Morisky. Resultados: Apenas 23,9% dos participantes foram considerados aderentes ao tratamento medicamentoso, e estes apresentaram, significativamente, melhores níveis de hemoglobina glicada (p=0,048), glicemia de jejum (p<0,001) e colesterol total (p=0,028). Conclusão: Houve relação entre a adesão aos antidiabéticos orais e algumas variáveis do controle metabólico, como hemoglobina glicada, glicemia de jejum e colesterol total. Dessa forma, a adesão medicamentosa deve ser, cada vez mais, incentivada entre as pessoas com Diabetes mellitus.

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Section: Methodsmentioning

confidence: 99%

Controle metabólico e adesão medicamentosa em pessoas com diabetes mellitus

et al. 2017

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Section: Fructose Consumption and Its Complicatons: The Role Of Strenmentioning

confidence: 99%

“…A decade later, Treuth et al [87] showed evidence on the relationship of strength training with adiposity control and, consequently, obesity. After 16 weeks of exercise performed 3 times per week, the authors observed that although the body weight of participants was not changed, the amount of intra-abdominal adipose tissue was significantly reduced [88].Recent studies have provided us with a better understanding of how strength exercise is able to improve for glycemic control. A performed study which used obese animals and submitted them to strength exercise on staircase [89], besides confirming reductions in serum insulin levels showed that after 8 weeks of training some proteins from insulin pathway had increased their action, such as phosphatidylinositol 3-kinase (PI3-K) and Akt.…”

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Fructose Consumption in the Development of Obesity and the Effects of Different Protocols of Physical Exercise on the Hepatic Metabolism

Pereira

Botezelli

Rodrigues

et al. 2017

Preprint

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Fructose consumption has been growing exponentially and, concomitant with this, the increase in the incidence of obesity and associated complications has followed the same behavior.Studies indicate that fructose may be a carbohydrate with greater obesogenic potential than other sugars. In this context, the liver seems to be a key organ for understanding the deleterious health effects promoted by fructose consumption. Fructose promotes complications in glucose metabolism, accumulation of triacylglycerol in the hepatocytes and alterations in the lipid profile, which, associated with an inflammatory response and alterations in the redox state, will imply a systemic picture of insulin resistance. However, physical exercise has been indicated for the treatment of several chronic diseases. In this review, we show how each exercise protocol (aerobic, strength or a combination of both) promote improvements in the obesogenic state created by fructose consumption as an improvement in the serum and liver lipid profile (HDL increase and decrease TG and LDL levels) and a reduction of markers of inflammation caused by an excess of fructose. Therefore, it is concluded that the practice of aerobic physical exercise, strength or a combination of both is essential for attenuating the complications developed by the consumption of fructose.Keywords: fructose; obesity; liver, aerobic exercise, strength exercise, combined exercise. Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 28 February 2017doi:10.20944/preprints201702.0103.v1Peer-reviewed version available at Nutrients 2017, 9, , 405; doi:10.3390/nu90404052 of 20 New story/old enemyThe high consumption of sugary beverages rich in fructose, is directly related to the development of obesity and its consequences, such as metabolic syndrome [1][2][3]. Concomitant with the increased incidence and prevalence of obesity and metabolic syndrome, the consumption of fructose has increased around 30% in the last 40 years [4]. More specifically, because fructose is less able to promote satiety and is more palatable, it will stimulate a higher consumption of food [4], and alter the metabolism of lipids and carbohydrates, thereby favouring the synthesis and accumulation of fat [5]. The accumulation of adipose tissue has come to be considered a global public health problem. The hypertrophy of this tissue generates harmful effects on the organism through the secretion of various types of adipokines, and for this reason obesity happens to be considered one of the major risk factors for the development of metabolic syndrome and, consequently, is listed as one of the most serious problems in relation to quality of life [6]. According to epidemiological data, it is expected that by 2025, approximately 18% of men and 21% of women worldwide will be considered obese [7]. With that in mind, since fructose consumption is strongly associated with the development of obesity, studies aimed at evaluating its role in the development of obesity are of paramount importance for a better und...

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“…Wykazywano wielokrotnie, że stężenie tej cytokiny jest istotnie większe u pacjentów z otyłością, cukrzycą typu 2 i chorobą niedokrwienną serca [18][19][20]. CHEM było zależne nie tyle od BMI badanych, co od ilości tkanki tłuszczowej trzewnej [21,22], a także -odwrotnie korelowało z insulinowrażliwością [23].Wysokie stężenie chemeryny może być markerem powikłań mikronaczyniowych cukrzycy -retinopatii i nefropatii [24,25].…”

Section: Dyskusjaunclassified

Chemerin concentration in children with type 1 diabetes

Zubkiewicz‐Kucharska¹,

Chrzanowska²,

Seifert³

et al. 2017

Pediatr. Endocrinol.

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Introduction. Chemerin (CHEM) is achemotactic factor. It promotes the recruitment of immune cells to the site of injury. It was demonstrated that CHEM increases insulin resistance and glucose intolerance, and its concentration correlates with blood glucose and lipid levels. The aim of the study is to evaluate the concentration of CHEM in children with type 1 diabetes mellitus (T1D) depending on metabolic control and the duration of the disease. Material and Methods. The study included 80 children aged 4-18 years (x = 12.6 ± 3.6) in the following groups: children with T1D diagnosed <2 years (N = 23), children with T1Ddiagnosed 2-5 years ago (N = 12), children with T1D for > 5 years (N = 27) and children with no evidence of hyperglycemia or any autoimmune diseases (controls, N = 18). Laboratory tests were performed to diagnose diabetes and to determine the metabolic control (including HbA1c, lipids, CRP, albumin in the urine, fundus examination, c-peptide). Furthermore, the concentrations of the following: CHEM, E-selectin, adiponectin, leptin, IFN-gamma were assessed. Anthropometric measurements were performed. Results. CHEM concentrations were comparable in the T1D andthe control group (55.65 ± 10.08 vs. 61.40 ± 16.65 ng / ml, p = 0.07), as well as leptin (6.27 ± 7 20 vs. 10.62 ± 13.86 ng / ml, p = 0.08) and IFN-γ (2.99 ± 3.45 vs.Słowa kluczowe chemeryna, cukrzyca typu 1, wyrównanie metaboliczne Streszczenie

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Serum Chemerin Levels are Associated with Visceral Adiposity, Independent of Waist Circumference, in Newly Diagnosed Type 2 Diabetic Subjects

Cited by 28 publications

References 31 publications

Controle metabólico e adesão medicamentosa em pessoas com diabetes mellitus

Controle metabólico e adesão medicamentosa em pessoas com diabetes mellitus

Fructose Consumption in the Development of Obesity and the Effects of Different Protocols of Physical Exercise on the Hepatic Metabolism

Chemerin concentration in children with type 1 diabetes

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