Serum chemerin and high-sensitivity C reactive protein as markers of subclinical atherosclerosis in Egyptian patients with type 2 diabetes

Abstract

Context: Chemerin is one of the adipokines that regulate fat metabolism. High-sensitivity C-reactive protein (hs-CRP) may be considered as a cardiovascular risk predictor. Measuring intima-media thickness of the CCA (C-IMT) is a well-evidenced tool for the detection of early stages of atherosclerosis. We aimed here to study both serum chemerin and hs-CRP as markers of subclinical atherosclerosis in Egyptian patients with type 2 diabetes, who are angiographically free of coronary artery disease (CAD). Subjects and methods: This cross-sectional study was conducted on 180 subjects divided into two groups: Group A included 90 type 2 diabetic patients without CAD and group B including 90 nondiabetic control subjects. All study subjects were having normal coronary angiography. Serum chemerin, homeostasis model assessment for insulin resistance (HOMA-IR), glycated haemoglobin (HbA1c), lipid profile, hs-CRP as well as C-IMT were assessed in all study subjects. Results: There was a statistically significant difference between the 2 groups regarding serum chemerin level, HOMA-IR, hs-CRP and C-IMT; being higher in the diabetic patients than in the control group (p = 0.006, 0.024, 0.040 and <0.001, respectively). There was positive correlation between serum chemerin level and waist-to-hip ratio (WHR), HOMA-IR, hs-CRP and C-IMT. Carotid intima-media thickness was positively correlated with patients' WHR, blood pressure, HbA1c, diabetes duration as well as hs-CRP, and negatively correlated with ankle-brachial index (ABI). Linear regression analysis showed that HbA1c, serum chemerin and hs-CRP were independently affecting C-IMT. Serum hs-CRP was positively correlated with HbA1c and HOMA-IR (p = 0.006 and 0.032, respectively), and negatively correlated with HDL-cholesterol level (p = 0.018). Conclusion: Both serum chemerin and hs-CRP could be considered as markers of subclinical atherosclerosis, and hence, may be utilized for the early detection of macrovascular disease, in Egyptian patients with type 2 diabetes.

Association of Circulating Chemerin With Subclinical Parameters of Atherosclerosis

“…In line with our observations, a recent study that analyzed data from diabetic, prediabetic, and healthy patients has observed no association of serum chemerin with cIMT when using adjusted regression models, 25 whereas 2 further cross-sectional reports have detected a significant positive association between these parameters. 18 , 19 To date, the relation between circulating chemerin and ABI has been examined only in 2 clinical studies, 19 , 26 but in contrast to our results, none of them has detected significant associations. Studies that used carotid plaques or carotid stenosis as an outcome variable revealed conflicting results by showing positive, 12 , 14 , 15 inverse, 22 or insignificant 21 , 23 relations.…”

Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients

“…BMI was the only variable that correlated with chemerin and there was no significant difference in the BMI between the two groups. Recently, several studies have reported that elevated circulating chemerin levels correlate with endothelial dysfunction and can be a biomarker of subclinical atherosclerosis (42)(43)(44). However, in our study, no such relationship between the chemerin levels, quantitative IMT, and arterial stiffness was observed.…”

High‐sensitivity C‐reactive protein as a biomarker in detecting subclinical atherosclerosis in psoriasis

“…[14][15][16]18,21,27,[31][32][33][34][35][36] Lachine et al introduced hs-CRP as a marker of subclinical atherosclerosis in type 2 DM. 16 In addition, the study conducted by Su et al corroborated a stronger correlation between hs-CRP and subclinical carotid atherosclerosis in prediabetic adults compared with those with normal glucose levels. 36 Taking into account the association of hs-CRP with both atherosclerosis and psoriasis, we believe that hs-CRP may play a great role in subclinical atherosclerosis in psoriasis.…”

“…15 As atherosclerosis has an inflammatory component and increased level of hs-CRP has been reported in various stages of atherosclerosis, measuring hs-CRP may be used as a possible marker for risk of atherosclerosis. 11,16,17 Some studies in the literature have previously described the increased levels of CRP and hs-CRP in patients with psoriasis. [18][19][20][21] Furthermore, previous studies have shown that patients with psoriasis have a higher risk of subclinical atherosclerosis.…”