High‐sensitivity C‐reactive protein as a biomarker in detecting subclinical atherosclerosis in psoriasis

Niknezhad, Nasim; Haghighatkhah, Hamid Reza; Zargari, Omid; Ghalamkarpour, Fariba; Younespour, Shima; Niknejad, Nakisa; Alikhan, Ali; Abdollahimajd, Fahimeh

doi:10.1111/dth.13628

Cited by 18 publications

(19 citation statements)

References 41 publications

(124 reference statements)

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“…Like psoriasis, vitiligo is not merely a skin disease, 11 and it is becoming increasingly recognized as a systemic condition in which patients may be at a higher risk of developing metabolic syndrome, atherosclerosis, and cardiovascular diseases. Although subclinical atherosclerosis has been described in some dermatological conditions such as psoriasis and hidradenitis suppurativa, 12,13 we were unable to find a study about subclinical atherosclerosis in vitiligo patients.…”

Section: Introductionmentioning

confidence: 83%

“…Moreover, the MIMT-CCA was significantly correlated with both the VASI score and duration of vitiligo; it is therefore proposed that severe and chronic inflammatory conditions may promote the risk of subclinical atherosclerosis. 12 The higher incidence of subclinical atherosclerosis in patients with vitiligo can be explained by the higher rates of metabolic syndrome and its components in these patients relative to the controls. 6,25 Finally, it should be noted that this association does not appear to be incidental, and vitiligo, like other inflammatory skin diseases, may increase the risk of metabolic syndrome and subclinical atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, vitiligo patients had greater MIMT‐CCA values and significantly more frequent subclinical atherosclerosis than healthy subjects. Moreover, the MIMT‐CCA was significantly correlated with both the VASI score and duration of vitiligo; it is therefore proposed that severe and chronic inflammatory conditions may promote the risk of subclinical atherosclerosis 12 …”

Section: Discussionmentioning

confidence: 99%

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Increased risk of subclinical atherosclerosis and metabolic syndrome in patients with vitiligo: a real association or a coincidence?

Namazi

Amani

Haghighatkhah

et al. 2021

Dermatologic Therapy

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Inflammatory and autoimmune skin diseases such as vitiligo may be associated with systemic disorders, including endocrine and cardiovascular diseases, due to some similarities in the pathogenesis. It was aimed to evaluate metabolic syndrome and subclinical atherosclerosis in patients with vitiligo. Seventy patients with nonsegmental vitiligo and 70 age-matched and gender-matched healthy controls participated in the study. These participants were investigated for metabolic syndrome criteria. The mean intima-media thickness of the common carotid artery (MIMT-CCA) of the subjects was measured for assessment of subclinical atherosclerosis. Metabolic syndrome and subclinical atherosclerosis were significantly more frequent in vitiligo patients compared with the controls (P = .006 and P = .002, respectively). In addition, metabolic syndrome and subclinical atherosclerosis had positive, significant correlations with the severity and duration of vitiligo (P = .031 and r = .482; P < .01, respectively). Our study suggested that patients with vitiligo, especially those with more chronic and severe disease or concomitant metabolic syndrome, are at a higher risk of developing cardiovascular diseases. Therefore, early diagnosis and treatment of metabolic syndrome in patients with vitiligo to prevent cardiovascular complications were recommended. K E Y W O R D S atherosclerosis, cardiovascular diseases, intima-media thickness of the common carotid artery, metabolic syndrome, vitiligo 1 | INTRODUCTION Vitiligo is an acquired skin disease characterized by the loss of functional melanocytes and the depigmentation of the skin and/or mucous membranes. The pathogenesis of vitiligo is not well known, though research has indicated the role of both genetic and environmental factors through a complex combination of inflammatory, immunologic, oxidative stress, and neural mechanisms. 1-3 Vitiligo may be associated with other autoimmune diseases such as autoimmune thyroid disease, inflammatory bowel disease (IBD), pernicious anemia, rheumatoid arthritis, systemic lupus erythematosus (SLE), Addison disease, and type 1 diabetes mellitus (DM). 1,2,4 In addition, some studies have reported an increased incidence of type 2 DM, dyslipidemia, and metabolic syndrome in vitiligo patients. 5 Proinflammatory cytokines that contribute to the pathogenesis of vitiligo such as tumor necrosis factor (TNF)-α and interleukin (IL)-1 and IL-6 are known to have a role in the development of insulin resistance as well as atherosclerosis. 6 Nastaran Namazia and Maliheh Amani contributed equally to this study.

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Section: Introductionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Increased risk of subclinical atherosclerosis and metabolic syndrome in patients with vitiligo: a real association or a coincidence?

Namazi

Amani

Haghighatkhah

et al. 2021

Dermatologic Therapy

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“…Patients in different stages of atherosclerosis have presented elevated hs‐CRP levels. Moreover, increased CRP or hs‐CRP levels have been reported in various inflammatory disorders, such as acne, hidradenitis suppurativa, type 2 diabetes, vitiligo, and psoriasis 29 …”

Section: Discussionmentioning

confidence: 99%

Assessment of selected angiogenesis markers in the serum of middle‐aged male patients with plaque psoriasis

Socha

Kiciński

Feldo

et al. 2021

Dermatologic Therapy

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Local angiogenesis accompanies inflammation in psoriasis‐affected skin. To determine the serum concentrations of selected pro‐ and anti‐angiogenic factors and their interrelationships in patients with plaque psoriasis. The study included 41 men diagnosed with psoriasis, aged 43.5 ± 11.7 years. The Psoriasis Area and Severity Index score was 23.4 ± 5.2 points. The control group consisted of 38 healthy, age‐matched men. The levels of pro‐angiogenic cytokines and angiogenesis inhibitors, including fibroblast growth factor 1 (FGF‐1), vascular endothelial growth factor A (VEGF‐A), endostatin, and angiostatin, were determined from the serum of patients and controls using enzyme‐linked immunosorbent assays. Compared with controls, patients with psoriasis had a significantly lower concentration of FGF‐1 (P = .01) but higher concentrations of endostatin (P = .04) and angiostatin (P = .02). The concentration of VEGF‐A was also higher in patients with psoriasis but not significantly (P = .25). The concentration of C‐reactive protein (CRP) was significantly higher among patients with psoriasis than controls (P < .0001). Among controls, CRP concentrations did not correlate significantly with the concentrations of FGF‐1, VEGF‐A, endostatin, or angiostatin. Among patients with psoriasis, CRP concentrations correlated moderately with the concentrations of VEGF‐A (r = .35; P = .02) and angiostatin (r = .31; P = .04). The concentration of VEGF‐A correlated positively with PASI (r = .05; P = .0009) and BSA values (r = .39; P = .01). Psoriasis is associated with an altered systemic balance between pro‐angiogenic and anti‐angiogenic factors. The increase in serum angiogenesis inhibitors may be associated with unfavorable changes in the development of coronary collateral circulation. However, the clinical significance of this has not yet been established.

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“…Previous reports correlated CRP levels to disease severity and demonstrated a significant decrease in CRP along the course of psoriasis treatemt. 4,5 Isha et al reported a significant decrease in CRP after NBUVB treatment (P < .001). 6 Another study evaluating CRP at baseline and 6 months after systemic treatment did not observe any correlation between the PASI and CRP.…”

mentioning

confidence: 95%

Therapeutic implications of C‐reactive protein and uric acid in patients with psoriasis before and after narrow band ultraviolet B therapy

Shalaby

Elshahid

Metwaly

et al. 2020

Dermatologic Therapy

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High‐sensitivity C‐reactive protein as a biomarker in detecting subclinical atherosclerosis in psoriasis

Cited by 18 publications

References 41 publications

Increased risk of subclinical atherosclerosis and metabolic syndrome in patients with vitiligo: a real association or a coincidence?

Increased risk of subclinical atherosclerosis and metabolic syndrome in patients with vitiligo: a real association or a coincidence?

Assessment of selected angiogenesis markers in the serum of middle‐aged male patients with plaque psoriasis

Therapeutic implications of C‐reactive protein and uric acid in patients with psoriasis before and after narrow band ultraviolet B therapy

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