Serum catestatin concentrations are decreased in obese children and adolescents

Šimunović, Marko; Šupe‐Domić, Daniela; Karin, Željka; Degoricija, Marina; Paradžik, Martina; Božić, Joško; Unić, Ivana; Škrabić, Veselin

doi:10.1111/pedi.12825

Cited by 23 publications

(36 citation statements)

References 55 publications

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“…Of note, catestatin suppressed hepatic glucose production and was associated with improved insulin sensitivity in mice with diet-induced obesity [45], while it also induced glucose uptake and GLUT4 trafficking in adult rat cardiomyocytes, thus, likely improving cardiac energetics [46]. One study performed among obese children and adolescents found that catestatin negatively correlated with the homeostatic model assessment of insulin resistance (HOMA-IR) and its levels were significantly reduced in obese subjects, compared to the control group [47]. CST also improved peripheral leptin sensitivity and promoted lipolysis and fatty acid oxidation in a preclinical model [48], thus, confirming its antiobesic effect [49].…”

Section: Discussionmentioning

confidence: 99%

Catestatin in Acutely Decompensated Heart Failure Patients: Insights from the CATSTAT-HF Study

Borovac

Glavaš

Grabovac

et al. 2019

JCM

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The role of catestatin (CST) in acutely decompensated heart failure (ADHF) and myocardial infarction (MI) is poorly elucidated. Due to the implicated role of CST in the regulation of neurohumoral activity, the goals of the study were to determine CST serum levels among ninety consecutively enrolled ADHF patients, with respect to the MI history and left ventricular ejection fraction (LVEF) and to examine its association with clinical, echocardiographic, and laboratory parameters. CST levels were higher among ADHF patients with MI history, compared to those without (8.94 ± 6.39 vs. 4.90 ± 2.74 ng/mL, p = 0.001). CST serum levels did not differ among patients with reduced, midrange, and preserved LVEF (7.74 ± 5.64 vs. 5.75 ± 4.19 vs. 5.35 ± 2.77 ng/mL, p = 0.143, respectively). In the multivariable linear regression analysis, CST independently correlated with the NYHA class (β = 0.491, p < 0.001), waist-to-hip ratio (WHR) (β = −0.237, p = 0.026), HbA1c (β = −0.235, p = 0.027), LDL (β = −0.231, p = 0.029), non-HDL cholesterol (β = −0.237, p = 0.026), hs-cTnI (β = −0.221, p = 0.030), and the admission and resting heart rate (β = −0.201, p = 0.036 and β = −0.242, p = 0.030), and was in positive association with most echocardiographic parameters. In conclusion, CST levels were increased in ADHF patients with MI and were overall associated with a favorable cardiometabolic profile but at the same time reflected advanced symptomatic burden (CATSTAT-HF ClinicalTrials.gov number, NCT03389386).

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Section: Discussionmentioning

confidence: 99%

Catestatin in Acutely Decompensated Heart Failure Patients: Insights from the CATSTAT-HF Study

Borovac

Glavaš

Grabovac

et al. 2019

JCM

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“…Obese children and adolescents have a significantly lower serum CST levels than those in healthy controls. In a cohort of obese children, those with any symptoms of metabolic syndrome or increased cardiovascular risk had the lowest serum CST levels[ 45 ].…”

Section: Granin Peptides In Glucose Homeostasismentioning

confidence: 99%

Role and function of granin proteins in diabetes mellitus

Herold¹,

Doleschall²,

Somogyi³

2021

WJD

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The granin glycoprotein family consists of nine acidic proteins; chromogranin A (CgA), chromogranin B (CgB), and secretogranin II–VIII. They are produced by a wide range of neuronal, neuroendocrine, and endocrine cells throughout the human body. Their major intracellular function is to sort peptides and proteins into secretory granules, but their cleavage products also take part in the extracellular regulation of diverse biological processes. The contribution of granins to carbohydrate metabolism and diabetes mellitus is a recent research area. CgA is associated with glucose homeostasis and the progression of type 1 diabetes. WE-14, CgA 10-19 , and CgA 43-52 are peptide derivates of CgA, and act as CD4 + or CD8 + autoantigens in type 1 diabetes, whereas pancreastatin (PST) and catestatin have regulatory effects in carbohydrate metabolism. Furthermore, PST is related to gestational and type 2 diabetes. CgB has a crucial role in physiological insulin secretion. Secretogranins II and III have angiogenic activity in diabetic retinopathy (DR), and are novel targets in recent DR studies. Ongoing studies are beginning to investigate the potential use of granin derivatives as drugs to treat diabetes based on the divergent relationships between granins and different types of diabetes.

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“…There are no significant correlations between serum CgA and CgB levels [ 47 ]. Serum catestatin levels are decreased in patients with metabolic syndrome compared with patients in the control category [ 51 ].…”

Section: Biomarker For Diabetes Metabolic Syndrome and Cardiovascular Diseasementioning

confidence: 99%

The Emerging Roles of Chromogranins and Derived Polypeptides in Atherosclerosis, Diabetes, and Coronary Heart Disease

Watanabe

2021

IJMS

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Chromogranin A (CgA), B (CgB), and C (CgC), the family members of the granin glycoproteins, are associated with diabetes. These proteins are abundantly expressed in neurons, endocrine, and neuroendocrine cells. They are also present in other areas of the body. Patients with diabetic retinopathy have higher levels of CgA, CgB, and CgC in the vitreous humor. In addition, type 1 diabetic patients have high CgA and low CgB levels in the circulating blood. Plasma CgA levels are increased in patients with hypertension, coronary heart disease, and heart failure. CgA is the precursor to several functional peptides, including catestatin, vasostatin-1, vasostatin-2, pancreastatin, chromofungin, and many others. Catestatin, vasostain-1, and vasostatin-2 suppress the expression of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 in human vascular endothelial cells. Catestatin and vasostatin-1 suppress oxidized low-density lipoprotein-induced foam cell formation in human macrophages. Catestatin and vasostatin-2, but not vasostatin-1, suppress the proliferation and these three peptides suppress the migration in human vascular smooth muscles. Chronic infusion of catestatin, vasostatin-1, or vasostatin-2 suppresses the development of atherosclerosis of the aorta in apolipoprotein E-deficient mice. Catestatin, vasostatin-1, vasostatin-2, and chromofungin protect ischemia/reperfusion-induced myocardial dysfunction in rats. Since pancreastatin inhibits insulin secretion from pancreatic β-cells, and regulates glucose metabolism in liver and adipose tissues, pancreastatin inhibitor peptide-8 (PSTi8) improves insulin resistance and glucose homeostasis. Catestatin stimulates therapeutic angiogenesis in the mouse hind limb ischemia model. Gene therapy with secretoneurin, a CgC-derived peptide, stimulates postischemic neovascularization in apolipoprotein E-deficient mice and streptozotocin-induced diabetic mice, and improves diabetic neuropathy in db/db mice. Therefore, CgA is a biomarker for atherosclerosis, diabetes, hypertension, and coronary heart disease. CgA- and CgC--derived polypeptides provide the therapeutic target for atherosclerosis and ischemia-induced tissue damages. PSTi8 is useful in the treatment of diabetes.

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Serum catestatin concentrations are decreased in obese children and adolescents

Cited by 23 publications

References 55 publications

Catestatin in Acutely Decompensated Heart Failure Patients: Insights from the CATSTAT-HF Study

Catestatin in Acutely Decompensated Heart Failure Patients: Insights from the CATSTAT-HF Study

Role and function of granin proteins in diabetes mellitus

The Emerging Roles of Chromogranins and Derived Polypeptides in Atherosclerosis, Diabetes, and Coronary Heart Disease

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